Emmion:
@ FSB,

thanks a great deal for the information. I have been looking for someone like you to help out. There is this lady i have been seeing for a while. I love her so much and marriage ASAP is already in my plans but there is the problem of genotype. This breaks my heart so much. I have gone for genotype test 3 times. First one i was given AC. Second was AA. Wanting to be doubly (or triple sure), i went for a third test and it turned out to be AC. Now my girlfriend also is AC. For me thats a problem. My parents are both AA. My elder brother is AA. So where did i get the AC from? I am confused. I love this girl but dont want pains for her and myself later when we start having children.

Please, i desperately need immediate advice. Any other Doctor in the house pls help.

My dear if both your parents are of the AA Hb genotype, u can't be any different. Go to a reputable hospital for hemoglobin test.

Look at How people made intelligent comments back then, compared to now that kids and political beggars cum tribalism heroes are everywhere!

ABC OF GENOTYPE
..
Genotype & It's Appropriate Suitor:
AA + AA = Excellent
AA + AS = Good
AA + SS = Fair
AS + AS = Bad
AS + SS = Very Bad
SS + SS = Extremely Bad (In fact, don't try it)
#SickleCellAwareness

Hmmmm lover boy. I can see the happiness in you. Abeg give us shark joor and don't forget to post your pre wedding pictures.

Treaty:
What can i say, i got a suprising reply of my fiancee being SC dou she said she recieved a treatment and has not fell sick since she was like 12yrs old , i wz still scared of loosing the damsel , going online, i stumbled across this thread, FMB n BlueDiva, u guys are d bomb i rilly hope we get more pple like in our hospitals not th half bake doctors who are out for the money n have forgotten their oaths. Well i am AA n i believe she is all mine nw . tanx f d info and 2 all not compatible , still look arnd for some-else it will not only do your family no good but humanity also . Wish u all d best in your search .

This kind of post should be the ones moved to fp and not a celeb drinking water or so!

Sanchez01:


AA + AA = AA, AA, AA, AA
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SS, SS
AC + AC = AA, AC, AC, SS

Replace that with CC

queentayo:
TREATMENT - I wonder if anyone has good idea on treatment of SS
NICOSAN is the dispute over, is it readily available, "is it a near cure"
Ciklavit r d testimonies by users as good as those given by nicosan users, is it readily available for both
adult and babies
Herbal medicines ??

Any other known used and proven medication FSB and others well vast in this area your suggestions would be highly appreciated

u a sickler ?

This are the kind of threads we need on front page

Wonderful.

lepasharon:


What kind of source is that? A Nigerian blog ..seriously? They first said HB CC was a type of a hemoglobin And went onto say it is Sickle cell Confused much?

Dont be misinformed Hemoglobin CC is a type of hemoglobin in its own own right and has nothing to do with Sickle cell.

Other rare hemoglobin variants are D and E

The popular ones are hemoglobin A and S. Hemoglobin A is the usual hemoglobin in ppl, although variants of the normal hemoglobin dont always cause problems

So a Nigerian blog is incapable of dishing out something sensible

Although I am not a medical practitioner like I earlier mentioned, time and time again you have proven you don't have a full grasp of the discourse yourself. Below is a journal by Murphy JR concerning the back and forth, and I'd really love to see you respond after this.

Hemoglobin CC disease: rheological properties of erythrocytes and abnormalities in cell water

Abstract

Suspensions of erythrocytes from patients with hemoglobin (Hb) CC disease showed an increased viscosity and decreased filterability suggesting a less deformable cell. Hemolysates prepared from Hb CC erythrocytes had an increased viscosity compared with hemolysates of normal cells, suggesting that the increased viscosity of Hb CC cells in serum was the result of an increased internal viscosity of the cell. These abnormal rheological properties of Hb CC erythrocytes were associated with a decreased content of cations and an abnormality of cell water. The fraction of the cell volume, which is water in Hb CC cells, was 95.5% of normal. The amount of cell water in Hb CC cells available for osmotic equilibrium, termed solvent water, was only 67% of that in normal cells. The smaller amount of solvent water in Hb CC cells indicates a greater amount of water bound to protein.

Altered rheological properties of erythrocytes with Hb AA, CC, and SC also were observed during pregnancy. Suspensions of erythrocytes in serum or plasma from pregnant patients resulted in an increased viscosity compared with suspension in serum or plasma from nonpregnant individuals. An increased viscosity during pregnancy is consistent with the increased severity of the hemolytic anemia in patients with these hemoglobinopathies during pregnancy. The studies reported here suggest that in Hb CC disease the mechanism of erythrocyte destruction, splenic sequestration, results from the increased viscosity, and less deformability of the erythrocyte with on increased internal viscosity.

https://www.ncbi.nlm.nih.gov/pubmed/5658583

How about we play a bit and run to Wikipedia?

Haemoglobin C (abbreviated as Hb C or HbC) is an abnormal haemoglobin in which substitution of a glutamic acid residue with a lysine residue at the 6th position of the β-globin chain has occurred (E6K substitution).

Combinations with other conditions[edit]
Individuals with sickle cell–hemoglobin C (HbSC), have the gene for HbS inherited from one parent and the gene for HbC is inherited from the other parent: they are "heterozygous". Since HbC does not polymerise as readily as HbS, there is less sickling (fewer sickle cells). The peripheral smear demonstrates mostly target cells and only a few sickle cells. There are fewer acute vaso-occlusive events. However, persons with haemoglobin SC disease (HbSC) have more significant retinopathy, ischemic necrosis of bone, and priapism than those with pure SS disease.

https://en.wikipedia.org/wiki/Hemoglobin_C

In your words;

Dont be misinformed Hemoglobin CC is a type of hemoglobin in its own own right and has nothing to do with Sickle cell.

Guess what Wikipedia believes...

Individuals with sickle cell–hemoglobin C (HbSC), have the gene for HbS inherited from one parent and the gene for HbC is inherited from the other parent: they are "heterozygous". Since HbC does not polymerise as readily as HbS, there is less sickling (fewer sickle cells).

Arguments drain me, to be honest, and you have not really assisted a clueless noob as myself as far as genotypes are concerned.

lepasharon:


Your quality of life is fine already

Lol
What's the basis of your answer??

Engrgeneral:
Please I need education on the marriage of two AS individuals, kindly support answers with medical history and facts please. God bless you all

biko ,don't put head there for the sake of your unborn children and your future peace.my neighbours are both as and have had 5 children with 3being sicklers (as).before they relocated they buried 2 below 5 yrs respectively,while the other is being rushed to the hospital biweekly.
pls think it well.the crossing of 2 As will produce an AA(normal),2 AS(carriers) and 1 ss(suckler).1 in 4 of your children will be a sickler.

fatymore:
We should take time to know about our genotype before going deep in the relationship.. Before you ask a gal out. Ask her what's your genotype

What's your genotype?

fsb:
To understand what AC is, I believe it'll be best you understand what the normal is?

The story goes,

What you have following in your blood are cells, the most predominant of which are called RED BLOOD CELLS (RBCs). These cells contain within them HEMOGLOBIN, a substance without which the RBCs are invariably useless. This hemoglobin itself is composed of 2 parts: a heme (don't bother yourself, this basically is a complex Iron-protein complex) and globin (2 pairs of protein chains, this is the important part).

There are 2 alpha and 2 beta globin chains - the pair, and there is a normal way the chains are supposed to be structured. The error happens when a protein substitution occurs in any one of these chains - but particularly in the globin chains (First of all, you have to understand that amino acids are the building blocks of proteins - so if amino acid 'x' is the normal, an abnormality occurs when instead of 'x' at a particular location along the chain, you have 'y'.)

That is as simple as it gets. These errors of substitution are given the big name of 'THALASSAEMIAS'. In reality, a substitution will occur at any point along either the alpha or beta chains but for the purposes of simplicity and to answer your question, we focus on the genotypes AS, SS, AC.

Genotype AA: At position 6 of both globin chains,the amino acid is GLUTAMATE
Genotype AS: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have VALINE
Genotype SS: At position 6 of both globin chains, the amino acid is VALINE
Genotype AC: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have LYSINE

I hope you can appreciate the above. This little substitutions can cause significant differences in the quality of life that you experience with a genotype.

I'll post this and continue with HOW DO PEOPLE GET THEIR GENOTYPES!!!

Very simple and self explanatory, I love it.......

Abiagirl777:



biko ,don't put head there for the sake of your unborn children and your future peace.my neighbours are both as and have had 5 children with 3being sicklers (as).before they relocated they buried 2 below 5 yrs respectively,while the other is being rushed to the hospital biweekly.
pls think it well.the crossing of 2 As will produce an AA(normal),2 AS(carriers) and 1 ss(suckler).1 in 4 of your children will be a sickler.

Correct me but I don't think your calculation is correct. Rather, for every birth, an AS+AS couple has a 25% chance of birthing an SS child.
My advice: For any that can produce SS kindly be mature and refrain from such relationship.

yes there is, my genotype is AC and am very hale and hearty, bt am prone to malaria, bt I dnt know if it's because my genotype is AC.

orimahspence:
,I have had several genotype test before ,I used to be AS
just last year I went for a test and result shown to be SC, so suprised , I'm as fit as fiddle, I'm not a sickler , that's when I stop taking this genotype things serious

The lab where you did your last test is probably wrong.Go to a reputable lab and get the test done again.

Oga you just come here dey show urself wen the exam don finish and e sure for me pass death say you no write am like dis infact u no write anything.

Anonylander:
I'm AC as well. Always feeling cool lmao. Good to see this on fp. Hope to see a thread on rhesus incompatibilities on fp soon as it seems like people are beginning to forget about that one as well.
C separates better/clearly from A on the cellulose acetate electrophoresis thingy

This is sooo true

Lanceslot:
What's your genotype?

AS

Lanceslot:
What's your genotype?

As

Stem cell transplant is the only cure for sickle cell. Good diet, regular medications and avoidance of precipitants prevent crises.

Very Educative. I am AC and treat malaria frequently.

I dunno, heard somewhere that pple with d genotype AS hardly fall sick compared to AA. I mean lyk having malaria, typhoid, frequent headaches... Is dis true?

wow... Year 2008's post got to FP in the year 2017! Wooooow.
Lessons:
1. Dont lose hope
2. Dont give up
3. Persevere and keep going,it's not too late for things to start getting better in your life

[quote author=blueskies post=57099660]I dunno, heard somewhere that pple with d genotype AS hardly fall sick compared to AA. I mean lyk having malaria, typhoid, frequent headaches... Is dis true?


so i heard too from the clinic where i conducted my test. Im AA though.

To be candid, I neva knew there was AC ND others.
This thread is very informative can't thank d doctors enough who contributed., may God continue to use u in saving lives.

these re topics DAT shud b on fp

[quote author=BrightForYou post=57100157][/quote]

I'm also AA, my sis is AS n she hardly falls ill with malaria, typhoid, headaches, unlike me. I use blood tonic often. Does dis happen, I mean AS rarely falling ill while its smtyms frequent with AA... ?

Is AB a genotype and what blood group does it belong to?

[quote author=blueskies post=57100798]

I'm also AA, my sis is AS n she hardly falls ill with malaria, typhoid, headaches, unlike me. I use blood tonic often. Does dis happen, I mean AS rarely falling ill while its smtyms frequent with AA...

Not quite. But i also believe it depends on individuals... Eventhough i'm AA,i rarely fall sick. I only fall sick when i overstress myself,physically and sometimes emotionally. But not a very serious one. I get well when i take warm baths and a lot of rest...

Sanchez01:

How about we play a bit and run to Wikipedia?

Arguments drain me, to be honest, and you have not really assisted a clueless noob as myself as far as genotypes are concerned.

Individuals with sickle cell–hemoglobin C (HbSC), have the gene for HbS inherited from one parent and the gene for HbC is inherited from the other parent: they are "heterozygous". Since HbC does not polymerize as readily as HbS, there is less sickling (fewer sickle cells). The peripheral smear demonstrates mostly target cells and only a few sickle cells.

You lack understanding. When a person is heterozygous for HBSC then obviously you call it sickle cell-hemoglobin C notice the hyphen.

But hemoglobin C as a hemoglobin variant has nothing to do with sickle cell. They are not the same. The symptoms are quite similar and sometimes overlap which is why ppl sometimes talk about one and bring up the other.


Why did you now skip this bit?

https://en.wikipedia.org/wiki/Hemoglobin_C

Hemoglobin C disease is not a form of sickle cell disease.

tomdon:


Lol
What's the basis of your answer??

because you are AC and you shouldnt have any clinical symptoms because of ur hemoglobin