1. Stone Man’s Disease
Medically known as fibrodysplasia ossificans progressiva (FOP).

Stone Man’s Disease is one of the rarest, most incapacitating genetic conditions. True to its common name, bone tissue begins to grow where muscles, tendons, and other connective tissues should be, effectively restricting movement. Individuals with FOP may even grow a second skeleton that will eventually turn them into living statues. Around the world, there have only been 800 confirmed cases, and there is no known cure or treatment other than painkillers. Those with FOP experience flare-ups randomly or following physical trauma—even something as small as an injection can cause bone to begin growing
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2. Progressive Lipodystrophy
Sometimes called reverse Benjamin Button syndrome.

lipodystrophy makes sufferers look old beyond their years. In the case of 15-year-old Zara Hartshorn, she was once mistaken for the mother of her older, 16-year-old sister. lipodystrophy is characterized by the loss of fat tissuefrom beneath the skin. Most commonly, fat loss occurs in the face, followed by the neck, upper extremities, and trunk. This can cause dents, folds, and wrinkles in the skin.
So far, only 200 cases have been reported worldwide, mainly affecting women. There is no cure or treatment for lipodystrophy.
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3. Xeroderma Pigmentosum

Those affected by xeroderma pigmentosum (XP) have extreme sensitivity to ultraviolet light. A mutation that interferes with the repair of DNA is the cause of the condition. Symptoms usually first appear in early childhood, marked by severe sunburn after just a few minutes of exposure. Freckling of the face and exposed skin is common, as well as dry skin and changes in skin color.
Unfortunately, individuals with XP have a high chance of developing skin cancer. Without proper protection, nearly half of all children with XP develop some type of skin cancer by the age of 10. The eyes also become bloodshot, hazy, and irritated from UV exposure.
There are eight different types of XP, each with its own severity and symptoms. It is estimated that only one in 250,000 people in Europe and the US has XP.
{at least now u know how vampires came 2 be}


4. Hereditary Sensory Neuropathy Type I

This disease is so rare that its prevalence is simply an estimate: two cases per one million people. Those with hereditary sensory neuropathy type 1 (HSN) suffer from a loss of sensation, usually in the legs, feet, arms, and hands. The ability to sense pain and temperatureis affected, sometimes to the point where it is absent.


5. Alopecia Areata

This is an autoimmune disease where the immune system mistakenly attacks hair follicles on the head, resulting in patchy hair loss. Alopecia areata (AA) has two other forms. Alopecia totalis is the complete loss of hair on the scalp. Alopecia universalis is the rarest form of AA, which attacks all hair follicles, including head hair, eyebrows, leg hair, lashes, and so on. Strangely, in all three forms, hair can regrow randomly and unpredictably.
Even though it affects about 2 percent of the population, there is no cure or treatment, and no symptoms are reported other than itchy, sensitive skin during the early stages of AA.
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6. Hypertrichosis, “Werewolf Syndrome”

those who suffer from hypertrichosis have abnormal hair growth covering their bodies. Faces can be completely covered in long hair, which is why the condition has earned the nickname of “werewolf syndrome.”
Hypertrichosis can be either congenital or acquired. Those born with the condition can suffer from one of several known genetic mutations. Some who get the condition later in life acquired it as a side effect from anti-balding treatments, though there are some who do not have an obvious cause. Treatment options include traditional methods of hair removal, though even waxing and laser treatments typically don’t provide long-lasting results
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Chai! Some people have got it so bad, i thank whatever deity out there looking out 4 me