The senior quartet are all sidelined for the Group E clash in Russia due to injury.

Manager Mauricio Pochettino told the official Tottenham website on Monday afternoon that Dier, Dembele, Rose, Sissoko and Harry Kane have not travelled with the senior squad to Moscow due to injury.

as Spurs aim to ignite their campaign after an opening-match defeat to Monaco.

Dier, Dembele and Rose missed Saturday’s 2-1 win over Middlesbrough, while Sissoko was substituted in the 70th minute with suspected concussion and it remains unclear whether they will be in contention for the trip to Arena Khimki.

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