I appeal to moderator to change the topic to"Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To Child with Sickle Cell Disorders

practicalclass:
A+ mother marrying O+ father giving birth to A- child is possible if one of the parent is heterozygote or both are i.e Rh+Rh- in one of the parent or both parents.

Quite true
Rh + = Rh +/+
Rh + = Rh +/-

nelszx:


Not possible
Here's the analysis of the possible phenotypes to the different Rhesus group;

Rh + = Rh +/+

Rh - = Rh -/-
Rh - = Rh -/+

Only Rh - can give out both negative or positive in an heterozygous state.

I think you miss it. Rhesus positive could be DD or Dd. Rhesus negative is dd. if parents are Dd and Dd which both are Rhesus positives. Using mendelian law of inheritance,possible outcome are DD,Dd,Dd,dd.

joyandfaith:

I think you miss it. Rhesus positive could be DD or Dd. Rhesus negative is dd. if parents are Dd and Dd which both are Rhesus positives. Using mendelian law of inheritance,possible outcome are DD,Dd,Dd,dd.

That I have corrected

AA and AS can not produce SS. unless AS and SS.

naijaking1:


If the glutamic acid mutates to valine, we have Beta-s, or HbS.
Mutation to lysine gives rise to thalassamia

With due respect, this is actually wrong. Beta-S is not the same as HbS. Again point mutation of glutamic acid to lysine does not result in thalasaemia but HbC.

Mutation of glutamic acid to valine leads to HbS.

Normal Haemoglobin has both 2-alpha and 2-beta chains. During production of haemoglobin, if there is deficiency in any of these chains such that it is no longer complete, it results to thalasaemia, which could be alpha or beta thalasaemia depending on which chain is deficient.

This defective gene CANNOT be detected through electrophoresis but by quantitative analysis.

Hb SC is a variant of Hb SS but they are both sickle cell anaemia.

Your brother can only marry someone who is Hb AA in other to have healthy offsprings.

Marrying someone who is AS, AC, SS, SC is a big No.

Cases of SC are treated same well as SS.


Cheers!

Just for correction Bro, HbSC and HbSS are not the same as sickle cell anaemia, but they are both forms of sickle cell disease.

It is only HbSS that is called sickle cell anemia.

Sickle cell disease is the presence of an abnormal Hb and HbS. Examples HbSC, HbSS, HbS-βthalasaemia, etc.

HbAC and HbAS are not forms of sickle cell disease because they both contain a normal haemoglobin, HbA.

I hope I have made some little sense.
I'm sure it was a typo error, just correct it Sir.
Cheers!!

sainty2k3:

You understand nothing about that study , so if the prevalence wasn't rare in 2009, u think it would be rare In 2017. , like I responded to a post by more intellectual fellow, there are researches ongoing which I'm aware of, centered on findind the prevalence of thalassemia using molecular studies, till its published we'll rely on the current knowledge and great contributions from the author of that articlw I quoted earlier.
So do I need to also clarify for you that beta thalassemia trait is the same as A-beta thalassemia which was the main subject of discuss in my post as it is mostly misdiagnosed as AA on our conventional HB electrophoresis

And yes you are disgracing our profession by ignoring a constructive way of argument to be using abusive words and insults, that's not a conduct expected from someone you claimed to be (that's if you are really who you claim to be)

I think the point you made here is clearer, the main thing is MISDIAGNOSIS not that it was confirmed by quantitative assay, from this premise therefore, it is impossible for a confirmed AA and AS to give birth to SS, except it was a case of wrong diagnosis.
Cheers!