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Effects Of Childhood Stress On Sperm MicroRNAs - Health - Nairaland

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Effects Of Stress On The Male Body System. / Effects Of Stress On Fertility / Effects Of Maternal Stress On Fetus (2) (3) (4)

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Effects Of Childhood Stress On Sperm MicroRNAs by Haleplushearty: 8:27am On May 23, 2018
Exposure to childhood stress can lead to poor physical and mental health in some people which can be passed on to their offspring. Studies in mice show how stress can be transmitted to offspring through environmentally-induced changes in sperm miRNA levels.

According to the new epigenetics study, the same is true in humans, it shows for the first time that the levels of the same two sperm miRNAs change in both men and mice exposed to early life stress. In mice, the negative effects of stress are transmitted to offspring.

Some children are vulnerable due to Lamarckian type inheritance derived from their parents’ experiences- Larry Feig, Ph.D., professor of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine and member of the Cell, Molecular and Developmental Biology and Neuroscience programs at the Sackler School of Graduate Biomedical Sciences at Tufts.

The human part of the study utilized the Adverse Childhood Experiences (ACE) questionnaire as an indicator of men’s early life trauma. The ACE Study questionnaire includes 10 yes or no questions about one’s experiences until the age of 18, including physical, verbal, or sexual abuse, and physical or emotional neglect. Other questions relate to one’s family members. Four or more yes answers put one at significantly increased risk for future mental and physical health problems.

miRNAs constitute a newly appreciated type of gene regulator, where each miRNA controls a distinct set of genes. Until recently, sperm from fathers were thought to contribute only DNA to the mother’s egg upon fertilization, but new data in mice indicate that sperm also contribute miRNAs that influence the next generation. Sperm miRNA expression in humans is known to be affected by environmental factors, such as smoking and obesity, but no human study to date has documented the effects of stress.

The new study found that among 28 Caucasian male volunteers, the expression of two highly related sperm miRNAs, miR-449 and miR-34, were inversely proportional to the men’s ACE scores. Men with the most extensive early abuse (highest ACE scores) had as much as a 300-fold reduction in the two sperm miRNAs compared to men with the least abuse.

The idea that these changes can affect the next generation is supported by additional findings in the study-the same sperm miRNA changes that take place in men with high ACE scores also occur in mice exposed to early life social instability stress, which Feig’s lab has shown previously leads to anxiety and sociability defects in female offspring of stressed males for at least three generations; these two sets of miRNAs are known to work together in mice to allow proper development of the brain and sperm in humans, miR-34c has been implicated in promoting early embryo development; the mouse studies showed that the decline in these sperm miRNA levels is transmitted to the next generation.

When these embryos mature, these miRNAs are also reduced in the sperm of their male offspring who pass on stress behaviors to their female offspring. This shows that stress is associated with altered levels of sperm miRNAs in humans.
[url]haleplushearty.org[/url]

Re: Effects Of Childhood Stress On Sperm MicroRNAs by BoboKush(m): 8:29am On May 23, 2018
Is that sperm or earpiece

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