I use photoshop CS. I'll combime some tips i got from Artboy with mine.
1. after scanning your drawing, unlock the layer then DESATURATE it (shift+ctrl+You).
2. use "Levels" (i.e.: Image>Adjustments>Levels or ctrl+L) to make the whites white and the blacks black. and to remove any unwanted grey ares.
3. use a white brush(B) to further remove any unwanted grey areas.
4. when u are satisfied, set the blend mode of the layer to "Multiply" and lock it.
5. create a new layer and drag it beneath the layer with the drawings.
6. fill with colors your new layer with lasso tool & paint bucket (put different colors on different layers, also make frequent use of groups). You can then
use airbrush tool to shade.
7. Save your frequently used styles by clicking on the 'new style' button in the layer style dialog box, so you won't have to recreate them.
8. Subscribe to tutorial sites
www.psdtuts.com,
www.psdfan.com,
www.pixel2life.com,
www.psdlearning et.c. They give step by step tutorials and with time you would get used to a few tricks.
9. Get used to shortcuts.
10. The Pen(P) & Brush(B) tools are very powerful tools, get used to them. I frequently use the pen tool/ stoke path.
I kind of new to photoshop & i'm really having a great time using it!
u might want to check out
http://huzeyk.blogspot(.com/2006/01/digital-comic-coloring.html@Raymond88: Hope that was helpful?