iSage:


You should confirm things before 'mis yarning' . You obviously don't know that insulin can't be given as a tablet- it will be digested by pepsin being that it's protein.

midnighter:


Yes now. Enzymes and stomach acid can degrade medicines and reduce bioavailability and absorbtion

DCmonster:
He said enzyme can destroy drugs! The question is can enzyme destroy drugs? The keyword being DESTROY!

midnighter:


Yes! If insulin reaches the stomach it will be rendered useless by proteases and it wont work. So that means it has been destroyed since its no longer useful

What is your own definition of the word "destroy"

DCmonster:
Go and read Hanty!

midnighter:


Lol you sef I dont know what you have been reading. What is wrong in saying that a enzymatic activity can destroy a drug?

A degraded and denatured protein, hasnt it been destroyed?

DCmonster:
olodo! Their is difference between inhibition, reduction in bioavailability and destruction. You said enzyme can destroy drugs. Can you write these in an examination without failing?

DCmonster:
In a best option mcq question if they ask you to pick between destroy, degrade, bind, reduce you will pick destroy abi?

midnighter:


We are not doing an MCQ. This is more of descriptive writing for a lay audience. Less need for specialist language here

The drug has been destroyed as far as it no longer works

Its good to write things in a way somebody can understand, especially in Nigeria where people are sensitive about "grammar"

ucham:


Good point. Your audience should be your priority. There's no point sounding like A specialist and trying to explain nuance to a lay audience. It defeats the purpose; which is educating the audience.

DCmonster humbly take correction and move on.

blowjohn:



U Don take PCM(paracetamol) injection before?
U go hail! Very painful

abdulkayus:


I have seen my double. Guy, we are on the same table, same WhatsApp group. I hate tablets like that. I prefer injections hundred times than tablets. But I have device a means to overcome that vomiting part of tablet or difficulties in taking tablets orally, what I do is to put each tablet in a handful of swallow #wink# like eba, semo or pounded yam, and swallow the mole. Lol. But despite all this measures, I still feel somehow when taking the tablets, but it is still better than just taking the tablets directly. Try it

AlphaStyles:
I fear injection and I hate drugs
I have injectophobia

But I still prefer drugs although injection move faster but I prefer drugs that is if it's not too much

Amuatulu:
I have a phobia for syringes "aichmophobia"
It makes me squirt!

Amuatulu:



Wo ho ti sen?

Amuatulu:
I have a phobia for syringes "aichmophobia"
It makes me squirt!
Would Love to administer one on you and watch you squirt.

midnighter:


Lol why didnt you explain the whole first pass stuff yourself

Odunolumide:


I'm not a doctor but I v read about it b4...so I was expecting a doctor to explain .

midnighter:


I meant that you are still capable of explaining it as long as you have read it

Odunolumide:


I am avoiding oversabi...lol

Are you a doctor? I just noticed your use of the term 'first pass'

midnighter:


Lol but you want to read somebody else's oversabi

No, I'm not. Were you? In a previous life

Odunolumide:


Maybe I am , I wouldn't know.
Except if you have a time capsule *lol
but I really wanted to be a doctor but JAMB disagreed. I have a diploma in a pharmaceutical technology though.

midnighter:


Wow. So what's your take on what that guy said?

Is saying that an enzyme can destroy a drug such a heinous crime as he's making it out to be??

Odunolumide:
this and the other post are not related. I didn't even criticise anyone's explanation . I only wanted an explanation from another angle.
and I tot we were vibing

midnighter:


I asked you because you have a pharmacology background.

Apologies! I think I understand your personality better now.