₦airaland Forum

Physicians at the University of Illinois Hospital & Health Sciences System have cured 12 adult patients of sickle cell disease using a unique procedure for stem cell transplantation from healthy, tissue-matched siblings.

The transplants were the first to be performed outside of the National Institutes of Health campus in Maryland, where the procedure was developed. Physicians there have treated 30 patients, with an 87 per cent success rate. The results of the phase I/II clinical trial at UI Health, in which 92 per cent of treated patients were cured, are published online in the journalBiology of Blood & Marrow Transplantation.

The new technique eliminates the need for chemotherapy to prepare the patient to receive the transplanted cells and offers the prospect of cure for tens of thousands of adults suffering from sickle cell disease.

About 90 per cent of the approximately 450 patients who have received stem cell transplants for sickle cell disease have been children. Chemotherapy has been considered too risky for adult patients, who are often more weakened than children by the disease.

“Adults with sickle cell disease are now living on average until about age 50 with blood transfusions and drugs to help with pain crises, but their quality of life can be very low,” says Dr. Damiano Rondelli, chief of hematology/oncology and director of the blood and marrow transplant program at UI Health, and corresponding author on the paper.

“Now, with this chemotherapy-free transplant, we are curing adults with sickle cell disease, and we see that their quality of life improves vastly within just one month of the transplant,” said Rondelli, who is also the Michael Reese Professor of Hematology in the UIC College of Medicine. “They are able to go back to school, go back to work, and can experience life without pain.”

Sickle cell disease is inherited. It primarily affects people of African descent, including about one in every 500 African Americans born in the U.S. The defect causes the oxygen-carrying red blood cells to be crescent shaped, like a sickle. The misshapen cells deliver less oxygen to the body’s tissues, causing severe pain and eventually stroke or organ damage.

Doctors have known for some time that bone marrow transplantation from a healthy donor can cure sickle cell disease. But few adults were transplanted because high-dose chemotherapy was needed to kill off the patients’ own blood-forming cells — and their entire immune system, to prevent rejection of the transplanted cells, leaving patients open to infection.

In the new procedure, patients receive immunosuppressive drugs just before the transplant, along with a very low dose of total body irradiation — a treatment much less harsh and with fewer potentially serious side effects than chemotherapy.

Next, donor cells from a healthy and tissue-matched sibling are transfused into the patient. Stem cells from the donor produce healthy new blood cells in the patient, eventually in sufficient quantity to eliminate symptoms. In many cases, sickle cells can no longer be detected. Patients must continue to take immunosuppressant drugs for at least a year.

In the reported trial, the researchers transplanted 13 patients, 17 to 40 years of age, with a stem cell preparation from the blood of a tissue-matched sibling. Healthy sibling donor-candidates and patients were tested for human leukocyte antigen, a set of markers found on cells in the body. Ten of these HLA markers must match between the donor and the recipient for the transplant to have the best chance of evading rejection.

In a further advance of the NIH procedure, physicians at UI Health successfully transplanted two patients with cells from siblings who matched for HLA but had a different blood type.

In all 13 patients, the transplanted cells successfully took up residence in the marrow and produced healthy red blood cells. One patient who failed to follow the post-transplant therapy regimen reverted to the original sickle cell condition.


http://www.punchng.com/health/healthwise/cure-for-sickle-cell-in-adults-validated/

Na oyinbo go dey find cure for our diseases.
Until we begin to fund research actively, we continue to be jokers!

twoondei:
Na oyinbo go dey find cure for our diseases.
Until we begin to fund research actively, we continue to be jokers!

You don see am finish. After dem go complain say oyinbo dey underlook Us and say afterall ee and Oyinbo na Same level.
our leaders past and present don use our god given destiny as a nation play ten ten

Mean while lets just keep focus on probes that will keep Nigerians distracted for the next 4 years.

A disease that is majorly African is being researched by Americans. Can't we do anything by ourselves?

Before we start rejoicing we need to know the overall cost of the procedure. I doubt if the African will be able to afford it.

Reeserches are mostly done within the four walls of the universities by the accademics and professors and their findings are usually published in journals and other mediums. But when we keep reading about rape scandals by the university dons, al la Unilcal dean of law faculty saga or Unilag's Baruwa' melodrama, are we surprised that no significant research findings are coming out of our ivory towers any more? Its a pity!