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Glutathione is synthesized from the amino acid cysteine, glutamate and glycine. It acts, when in its reduced form, as one of the major detoxifiers in the body. Glutathione is found in almost all cells. The liver, spleen, pancreas, and lens and cornea of the eye have the highest concentrations. Glutathione levels decrease with age. It acts as an antioxidant, protecting proteins, aiding liver detoxification and helping remove heavy metals from the body and is considered an essential antioxidant factor in slowing aging.


Parkinson's Disease is one of the several diseases where glutathione may play an important role. Many of the things which have been suggested as possible causes of Parkinson's Disease (including pesticides, iron, copper, zinc, manganese, mercury, lead, aluminum, and certain food borne toxins) are all oxidative stressors which deplete glutathione levels in the substantia nigra of the brain. A theory has been proposed [1] that low levels of glutathione put people at greater risk for developing Parkinson's. Experiments in administering glutathione to newly diagnosed patients produce striking improvement in function.[ 2 ,3] When given 600 mg twice a day for 30 days patients showed an average of 42% decline in disability.[4]

Glutathione plays several roles in cancer. It prevents cancer, protecting DNA from damage by detoxifying harmful chemicals and removing them from the body. Low glutathione levels predispose people to cancer. ÒPatients with a variety of malignant disorders were found to have a markedly lowered plasma glutathione level.Ó[5].

Glutathione also fights cancer. It selectively stimulates apoptosis (cell death) of malignant cells while leaving healthy cells unaffected.[6] It does this by regulating the tumor suppressor protein p53. Under normal conditions the p53 protein senses DNA damage in a cell and slows the rate of cell division, giving the cell time to repair itself. If the DNA cannot be repaired, p53 tells the cell to kill itself (apoptosis). Treatment with glutathione may reverse the cancer process. Various studies have shown glutathione reverses development of neuroblastoma, cervical carcinoma, leukemia, and other cancers.[7]

It also seems useful to combine glutathione with certain chemotherapy drugs, especially cisplatin, cyclophosphamine, and bleomycin. Glutathione decreases the toxic side effects of these drugs while either not affecting or increasing their therapeutic effect. Glutathione protects against nerve damage when using cisplatin to treat gastric [8] or ovarian cancer [9].

Its use with ovarian cancer is especially interesting. Ovarian cancer frequently responds to chemotherapy treatment in a dose dependent manner but toxic side effects frequently limit the amounts given. Using glutathione in conjunction with chemotherapy allows the use of higher more effective drug levels. [10]

A similar benefit is seen with radiation therapy. Administering glutathione prior to radiation treatment reduces unwanted side effects.[11, 12]

References:
1. Bains JS, Shaw, CA. Neurodegenerative disoreders in humans: the role of glutathione in oxidative stess- mediated neuronal death. Brain Res Rev 1997;25:335-358
2. Sechi G, Deledda MG, Bua G, et al. Reduced intravenous glutathione in the treatment of early Parkinson's disease. Progr Neuropsychopharmacol Biol Psychiatry 1996;20:1159-70.
3. Perlmutter D. BrainRecovery.com: Po werful Therapy for challenging Brain Disorders. Naples FL: The Perlmutter Health Center (brainrecovery.com) 2000
4. Sechi G, Deledda MG, Bua G, et al. Reduced intravenous glutathione in the treatment of early Parkinson's disease. Progr Neuropsychopharmacol Biol Psychiatry 1996;20:1159-70.
5. Beutler E., and Gelbart T. Plasma glutathione in health and in patients with malignant disease. J Lab Clin Med , 1985: 105;581-584.
6. Donnerstag B, et al. Reduced glutahione and S-acetylgluathione as slective apoptosis inducing agents in cancer therapy. Cancer Letters 1996;110 :63-70.


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Glutathione primarily was used to treat cancer patients. It was discovered that during treatment their skin started glowing and getting fresher, for which glutathione was formulated for skin Enhancement.

There is no known side effects.It is a food supplement and antioxidant. Your body needs it more than it need it you

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