₦airaland Forum

FreeIgboho:
Dangote better be careful. This is the kind of thing that has Bill Gates in trouble in certain quarters - crashing people's means of livelihood by donating it for free!

Are you okay at all? Just because of the gains of a few persons....

ChristCee:
Yep! You read that well and interestingly, most healthcare providers around the worldbdo not know this science.
The most likely explanation involves a mutation or undetected variant affecting the hemoglobin gene. Here are possibilities:

1️. “AA” parent actually has a silent or rare sickle mutation (e.g. β⁰-thalassemia, HbC, or HbD)
What happens: Some people test as AA on standard tests because they have a rare variant of the beta-globin gene that isn’t picked up by routine electrophoresis or sickle solubility tests.
If that parent actually carries a rare abnormal hemoglobin (like HbC, HbD Punjab, HbE, or β-thalassemia mutation), then pairing with AS could result in compound heterozygosity (e.g., SC, Sβ⁰-thalassemia).

Some of these combinations can behave clinically like SS (sickle cell disease).

🩺 How to test: Advanced testing like DNA sequencing of the HBB gene, or HPLC (High-Performance Liquid Chromatography) instead of standard electrophoresis.

2️⃣ De novo mutation (new S mutation arising during gamete formation)
What happens: A mutation spontaneously occurs in the sperm or egg, converting an A allele to an S allele. In simple terms your so called 'A' trait/gene reconstitutes itself into an 'S' gene.

This is very rare in sickle cell disease because the S mutation (Glu6Val) is well established in populations, but not impossible.

Estimated de novo mutation rate for the HBB gene is low, but if it happened in a germline mosaicism (parent has S mutation in some germ cells but not in blood), they can pass it on without showing AS in tests.

3️⃣ Laboratory testing error / Misclassification
This has happened in some regions where only solubility tests or basic electrophoresis were used.

If the "AA" status was determined long ago or outside of a specialized center, consider repeat testing with HPLC or molecular methods.

❓ Usually, this sort of trait as explained in 1 above can run in a family leading to lots of SID (sudden infant death) or lots of observed fatalities despite 'correct genotype match'

This obviously suggests an inherited silent or rare variant running in the family.
If multiple AA x AS couples are having SS children:
✅ More likely explanation: a family-wide rare hemoglobin variant or HBB mutation masquerading as "AA" in standard testing.

Think of it as a hidden carrier state.

🧪 What you should do to get better clarification.

Ask for:
✅ HBB gene sequencing (to check for all beta-globin mutations).
✅ HPLC or Capillary Electrophoresis (to detect rare hemoglobin variants).
✅ Parental genotyping (especially the so-called “AA” parent).

Seun

This is serious.

Ningishzida:
If you have any specific question, I will answer them to the best of my knowledge. I say this because if the teacher appears when the student is not yet ready, they will only end up awakening the Agent Smith within that student.


In the movie "The Matrix," Agent Smith didn't need to be everywhere, because anyone could become him. All it took was a threat to the status quo, and the familiar face in front of you was transformed into the face of control.
This dynamic doesn't just belong to Neo's world, but to ours as well.
How many times have you had a casual conversation with someone until you touch on a topic that negates the status quo? Suddenly, you no longer recognize who is in front of you: the tone changes, the mind closes, and without realizing it, that person becomes the defender of the status quo.
No weapons needed, no uniforms needed: the Matrix has trained them since childhood. Indoctrinated to protect the illusion, ready to reject anything that might even awaken a free thought.
This is how the System survives: not because of the masters, but because of the slaves who defend it.

Your write up is completely novel. Well I'm SC, I've often wondered why mosquitos are always after my life. I'll be in a room with people and those tiny bastards will focus mostly on me. Funny enough, I'm fine and I've never spent more than 4 hours in a hospital ever since I've been born and that was because of typhoid. I'm over 30. In fact, I don't fall seek even under serious stress and I'm a Project Civil Engineer.
I'll like to know more about the topic. You were about to talk about food geared towards SS/SC.

Mustybraun:
Toh, my candid advice to anyone that made any payment to somebody…start requesting for refund.

You have no idea