Reaching out to "high five" someone, grasping and moving objects of different shapes and sizes, feeding herself dark chocolate. For Jan Scheuermann and a team of researchers from the University of Pittsburgh School of Medicine and UPMC, accomplishing these seemingly ordinary tasks demonstrated for the first time that a person with longstanding quadriplegia can maneuver a mind-controlled, human-like robot arm in seven dimensions (7D) to consistently perform many of the natural and complex motions of everyday life.


In a study published in the online version of The Lancet, the researchers described the brain-computer interface (BCI) technology and training programs that allowed Ms. Scheuermann, 53, of Whitehall Borough in Pittsburgh, Pa. to intentionally move an arm, turn and bend a wrist, and close a hand for the first time in nine years.

Less than a year after she told the research team, "I'm going to feed myself chocolate before this is over," Ms. Scheuermann savored its taste and announced as they applauded her feat, "One small nibble for a woman, one giant bite for BCI."

"This is a spectacular leap toward greater function and independence for people who are unable to move their own arms," agreed senior investigator Andrew B. Schwartz, Ph.D., professor, Department of Neurobiology, Pitt School of Medicine. "This technology, which interprets brain signals to guide a robot arm, has enormous potential that we are continuing to explore. Our study has shown us that it is technically feasible to restore ability; the participants have told us that BCI gives them hope for the future."

In 1996, Ms. Scheuermann was a 36-year-old mother of two young children, running a successful business planning parties with murder-mystery themes and living in California when one day she noticed her legs seemed to drag behind her. Within two years, her legs and arms progressively weakened to the point that she required a wheelchair, as well as an attendant to assist her with dressing, eating, bathing and other day-to-day activities. After returning home to Pittsburgh in 1998 for support from her extended family, she was diagnosed with spinocerebellar degeneration, in which the connections between the brain and muscles slowly, and inexplicably, deteriorate.

"Now I can't move my arms and legs at all. I can't even shrug my shoulders," she said. "But I have come to the conclusion that worrying about something is experiencing it twice. I try to dwell on the good things that I have."

A friend pointed out an October 2011 video about another Pitt/UPMC BCI research study in which Tim Hemmes, a Butler, Pa., man who sustained a spinal cord injury that left him with quadriplegia, moved objects on a computer screen and ultimately reached out with a robot arm to touch his girlfriend.

"Wow, it's so neat that he can do that," Ms. Scheuermann thought as she watched him. "I wish I could do something like that." She had her attendant call the trial coordinator immediately, and said, "I'm a quadriplegic. Hook me up, sign me up! I want to do that!"

On Feb. 10, 2012, after screening tests to confirm that she was eligible for the study, co-investigator and UPMC neurosurgeon Elizabeth Tyler-Kabara, M.D., Ph.D., assistant professor, Department of Neurological Surgery, Pitt School of Medicine, placed two quarter-inch square electrode grids with 96 tiny contact points each in the regions of Ms. Scheuermann's brain that would normally control right arm and hand movement.

"Prior to surgery, we conducted functional imaging tests of the brain to determine exactly where to put the two grids," she said. "Then we used imaging technology in the operating room to guide placement of the grids, which have points that penetrate the brain's surface by about one-sixteenth of an inch."

The electrode points pick up signals from individual neurons and computer algorithms are used to identify the firing patterns associated with particular observed or imagined movements, such as raising or lowering the arm, or turning the wrist, explained lead investigator Jennifer Collinger, Ph.D., assistant professor, Department of Physical Medicine and Rehabilitation (PM&R), and research scientist for the VA Pittsburgh Healthcare System. That intent to move is then translated into actual movement of the robot arm, which was developed by Johns Hopkins University's Applied Physics Lab.

Two days after the operation, the team hooked up the two terminals that protrude from Ms. Scheuermann's skull to the computer. "We could actually see the neurons fire on the computer screen when she thought about closing her hand," Dr. Collinger said. "When she stopped, they stopped firing. So we thought, 'This is really going to work.'"

Within a week, Ms. Scheuermann could reach in and out, left and right, and up and down with the arm, which she named Hector, giving her 3-dimensional control that had her high-fiving with the researchers. "What we did in the first week they thought we'd be stuck on for a month," she noted.

Before three months had passed, she also could flex the wrist back and forth, move it from side to side and rotate it clockwise and counter-clockwise, as well as grip objects, adding up to what scientists call 7D control. In a study task called the Action Research Arm Test, Ms. Scheuermann guided the arm from a position four inches above a table to pick up blocks and tubes of different sizes, a ball and a stone and put them down on a nearby tray. She also picked up cones from one base to restack them on another a foot away, another task requiring grasping, transporting and positioning of objects with precision.

"Our findings indicate that by a variety of measures, she was able to improve her performance consistently over many days," Dr. Schwartz explained. "The training methods and algorithms that we used in monkey models of this technology also worked for Jan, suggesting that it's possible for people with long-term paralysis to recover natural, intuitive command signals to orient a prosthetic hand and arm to allow meaningful interaction with the environment."

In a separate study, researchers also continue to study BCI technology that uses an electrocortigraphy (ECoG) grid, which sits on the surface of the brain rather than slightly penetrates the tissue as in the case of the grids used for Ms. Scheuermann.

In both studies, "we're recording electrical activity in the brain, and the goal is to try to decode what that activity means and then use that code to control an arm," said senior investigator Michael Boninger, M.D., professor and chair, PM&R, and director of UPMC Rehabilitation Institute. "We are learning so much about how the brain controls motor activity, thanks to the hard work and dedication of our trial participants. Perhaps in five to 10 years, we will have a device that can be used in the day-to-day lives of people who are not able to use their own arms."

The next step for BCI technology will likely use a two-way electrode system that can not only capture the intention to move, but in addition, will stimulate the brain to generate sensation, potentially allowing a user to adjust grip strength to firmly grasp a doorknob or gently cradle an egg.

After that, "we're hoping this can become a fully implanted, wireless system that people can actually use in their homes without our supervision," Dr. Collinger said. "It might even be possible to combine brain control with a device that directly stimulates muscles to restore movement of the individual's own limb."

For now, Ms. Scheuermann is expected to continue to put the BCI technology through its paces for two more months, and then the implants will be removed in another operation.

"This is the ride of my life," she said. "This is the rollercoaster. This is skydiving. It's just fabulous, and I'm enjoying every second of it."

In addition to Drs. Collinger, Tyler-Kabara, Boninger and Schwartz, study co-authors include Brian Wodlinger, Ph.D., John E. Downey, Wei Wang, Ph.D., and Doug Weber, Ph.D., all of PM&R; and Angus J. McMorland, Ph.D., and Meel Velliste, Ph.D., of the Department of Neurobiology, Pitt School of Medicine.

The BCI projects are funded by the Defense Advanced Research Projects Agency, National Institutes of Health grant 8KL2TR000146-07, the U.S. Department of Veteran's Affairs, the UPMC Rehabilitation Institute and the University of Pittsburgh Clinical and Translational Science Institute.



http://www.sciencedaily.com/releases/2012/12/121217030957.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29

amazing mind control...

Summary pls

ok nah disability is nvr impossibility

Odi ok nice innovation

That means the issue of being hor.n.y is solved

in naija, thi is another lethal weapon especially in the hands of pickpocket

That's great. But how much will it cost.

Cool...when the rest of the world is getting more innovative and inventive, Nigerians are busy dealing wit corruption..tsk tsk

That's one small step for humanity and a giant leap for mankind. Nice job!

Allahu Akbar

dejust: That's great. But how much will it cost.

About the price of one cup of hmm.... Karry.

free2ryhme:

Guy, you deserve and e-slap !

And u've given it to him

She is psychic now

Amazinly awesome!

U see what science and tech has solved in a western nation if it were nigeria that woman will be killed by her family because she won't be catered for and be neglected .. Nigeria we able bodied people never fit get work or eat properly na disabled paralysed wan come eat -

For me this world would not end as people think. One day solution to end death would appear and people wud no longer die, people would be able to restore their damage limbs / restore health. Watch out

I can imagine the possibilities when this is perfected

Revolva: U see what science and tech has solved in a western nation if it were nigeria that woman will be killed by her family because she won't be catered for and be neglected .. Nigeria we able bodied people never fit get work or eat properly na disabled paralysed wan come eat -

You must be very stuuupid!!! I know you are trying to reflect on the Nigerain situation,but your comment is way out of line.. Come and see people with worst situations who are being catered for in naija and you will eat back your words....
This is how you people go about saying rubbish on the internet without thinking twice making strangers beleive it's true.. Abi no be the Nigeria wey me dey..
For the fact that your family can kill someone in such a situation doesn't mean that's what Nigerians do... Abeg,speak for yourself....
Rubbish

Baba Luku made related stuff such as Baby toy (Omo Langidi/Shigidi) that can talk. *laffs*

Ranks007: That means the issue of being hor.n.y is solved

God bless your soul of all things to come to mind in this situation[color=#006600][/color].

Teenage Money: Summary pls

is ur mendula oblongata relapsing?

Science and technology at its best

harlos: Science and technology at its best

almost

ciphoenix: almost

almost, more to come

harlos: almost, more to come

exactly

In time, we'll control everything with our minds. Phones, TV, computers, Games

ciphoenix: In time, we'll control everything with our minds. Phones, TV, computers, Games

even human being sef

harlos: even human being sef

already feeling like Charles Xavier