British scientists have taken a major step in developing a vaccine against hiv. They developed two prototype vaccine vector. The study was published in the journal "vaccine".

The prototype was developed by a team of researchers from royal holloway, university of london and imperial college london. It was based on chimpanzee adenovirus. They decided to use the variant of the chimpanzee because of its low prevalence in humans and, in recent studies, it was found that the human adenovirus increases the risk of hiv infection.

The researchers developed the chad3 and chad63 vectors. In studies in mice, scientists have used to produce these vectors transgene gag, pol and nef hiv. Findings have shown that t cells in mice responded to all three peptides induced only when chad3; with chad63, only two peptides responded. The magnitude of immune responses was influenced by the vector dose.

In general, the chimpanzee adenovirus vector are suitable candidates for the production of hiv proteins and can be used for a vaccine. However, it takes other pre-clinical tests, the study noted.

Report From http://www.viviangist.com/british-researchers-have-created-a-vector-prototype-hiv-vaccine

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