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Diabetes is known to increase the risk of kidney disease, kidney dysfunction also increases the risk of diabetes. The two-way relationship between kidney disease and diabetes is urea. The nitrogen-containing waste product in blood comes from the breakdown of protein in foods.

Kidneys normally remove urea from the blood, but it can build up when kidney function slows down. The findings are significant because urea levels can be lowered through medication, diet-for example, by eating less protein-and other means, thereby allowing for improved treatment and possible prevention of diabetes.

When urea builds up in the blood because of kidney dysfunction, increased insulin resistance and impaired insulin secretion often result. Researchers evaluated the records of different adults without diabetes over a five-year period, blood test that measures the amount of urea nitrogen found in the blood showed that some of them had elevated urea levels, signaling poor kidney function.
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