Antihistamines are used for fever, hives, conjunctivitis and insect bites. They are available over-the-counter and on prescription. Latest review shows that the drugs could have negative long-term side effects on male fertility because they tackle histamine – a molecule produced by the body in response to an allergy which drives reactions such as sneezing, wheezing and itching.

Histamines are involved in fertility, blocking them could have negative side effects. Anti-histamines can lower sperm count, while deforming sperm and making them slower swimmers in mice, rats and hamsters. It is produced when the immune system is threaten, it affects male libido, shape and swimming ability of men’s sperm. Anti-histamines, which block it from working normally are thought to disrupt the production of male sex hormones in the testicles.

Commenting on the research, Dr Channa Jayasena, senior clinical lecturer at Imperial College London, said: ‘The average sperm quality has been reducing over the last few decades, so it is always important to consider that medications may be responsible.
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