Researchers at Boston University School of Medicine (BUSM) looked at short-term effects of flavoring chemicals used in tobacco products like e-cigarettes on endothelial cells, cells that line the blood vessels. The researchers noticed that when blood vessels were exposed to flavoring additives, normally released chemicals to promote blood flow were decreased and increased inflammation, indicators of short-term toxicity.

There has been a rapid rise in e-cigarette use, partially due to flavoring additives in tobacco products and perception of less harm than traditional combustible cigarettes.The dangers of combustible cigarettes on the cardiovascular system has been known for decades, e-cigarettes are not safe because previous research confirmed that they are dangerous to blood vessels.

Researchers also found that endothelial cells from smokers showed the same toxicity as those treated with flavoring chemicals. Flavoring additives were directly toxic to blood vessels and have adverse effects that may have relevance to cardiovascular toxicity long-term similar to combustible cigarettes.
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