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Immunoglobulin Prevents HIV-1 Infection - Health - Nairaland

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Immunoglobulin Prevents HIV-1 Infection by Haleplushearty: 6:41pm On Jul 24, 2018
Scientists at Texas Biomedical Research Institute have discovered new defense against HIV-1, the virus that causes AIDS. They used an animal model to show that an antibody- Immunoglobulin M (IgM) was effective in preventing infection after mucosal AIDS virus exposure.

Rhesus monkeys at the Southwest National Primate Research Center on the Texas Biomed served as models for the in vivo study. They treated the animals with a human-made version of IgM, which is naturally produced by plasma cells located under the epithelium (the surface lining of body cavities). After one hour, the same animals were exposed to simian-human immunodeficiency virus SHIV. Four out of the six animals treated this were protected against the virus. The animals were monitored for 82 days.

They discovered that applying the IgM antibodies causes immune exclusion. IgM prevents the virus from crossing the mucosal barrier and spreading to the rest of the body. The technique of introducing pre-formed antibodies into the body to create immunity is passive immunization. The protective potential of mucosal anti-HIV-1 IgM. IgM has a five-times higher ability to bind to virus particles compared to the standard antibody form called IgG.
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Re: Immunoglobulin Prevents HIV-1 Infection by Amthol(m): 6:51pm On Jul 24, 2018
Its an out standing discovery though OP you need to simplify the post more so other members of this spectacular platform who are not Molecular scientist/researcher inclined can flow with the information

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Re: Immunoglobulin Prevents HIV-1 Infection by Osasnidas(m): 7:44pm On Jul 24, 2018
IgM is not a new imunoglobulin.. people with HIV at one point in their life will develop a HIV specific immunoglobin this will not last because of destruction of the helper t cells, which will direct plasma cells to produce more immunoglobins, plasma cells aren't immortal, igM have half lives, that's why memory cells are formed when the need to produce igM arises.. so no helper t cells no b cells differentiating to plasma and memory cells, and no HIV specific killer t cells, and studies shows that HIV antibodies and killer cells only appear at a late stage of the infection when the immune system has been compromised.. and viral loads is off the charts.. at this point HIV test proves positive..

HIV is very prone to mutation, it will change it's epitope. Immunoglobulins used on others won't make much effects as they will be eventually cleared from the system.

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