Coronavirus cases in the United States surged by at least 120,276 in the past 24 hours, according to a Reuters tally, the second consecutive daily record rise as the outbreak spreads in every region.
Yesterday, the country set a national record with nearly 105,000 new infections, according to a Reuters tally.
The tally is expected to push higher still when California's county-by-county data is added.
US cases have risen by more than 100,000 for three out of the past seven days, putting pressure on hospitals in several states and causing families to rethink their plans for Thanksgiving dinner on November 26.
Nineteen out of 50 states reported record one-day increases on Thursday (local time).
Previously, the most states that reported records for new cases in a single day was 16 on October 30, according to Reuters data.
While the spread of the virus is wide, the outbreak is hitting the Midwest particularly hard, based on daily new cases per capita.
Illinois reported nearly 10,000 new cases on Thursday (local time) and along with Texas is leading the United States in the most cases reported in the past seven days.
Other Midwestern states with record increases in cases on Thursday were Indiana, Iowa, Michigan, Minnesota, Missouri, North Dakota, Ohio and Wisconsin.
Arkansas, Maine, Kentucky, New Hampshire, Oklahoma, Rhode Island, Utah and West Virginia also set records for rises in new infections.
Some cities and states have announced new measures such as curfews or reduced gathering sizes to combat the spread of the virus, but the US has taken no action at the federal level.
Seventeen out of 50 states do not require people to wear masks.
Many countries in Europe are shutting high-risk businesses and even ordering national or regional lockdowns in the face of a second wave of the virus.
In addition to rising cases, US hospitalisations of COVID-19 patients rose to over 52,500 on Thursday, up for an 11th consecutive day and getting closer to the record of 58,370 set in July.