The best cryptocurrencies to invest in without regrets will remain the leading cryptos. From data presented by the high authority websites on cryptocurrencies and blockchain, Coinmarketcap has listed cryptos by their ranks and information; Bitcoin is known to be the leading on the list, given the fact that it's the first cryptocurrency to be created to work on the blockchain.
Ethereum's the second after Bitcoin in terms of marketcap and this is because of the general usecase of Ether.
In all, the general recommendation for safer investment remains picking the top ten cryptocurrencies by marketcap to invest in. This is largely due to the fact that these cryptocurrencies has strived hard to make it up the list among the thousands of cryptos out there and this is based on the community and team backings, usecase, roadmaps, whit paper and the likes.
Of it all Buying Bitcoin still remains the overall best option. Don't forget your safety and remember to Buy Bitcoin on reputable platforms.

There are so many factors to consider. You need to check key indications like Market capitalization, White papers, Price performance, utility and more. This as well as deep personal research forms my decision to invest in or not.

I got the information from this article: https://blog.bitmama.io/how-to-choose-the-right-coin-as-a-crypto-investor/