Cholera is caused by Vibrio cholerae and affects 1.3 to 4 million people each year and results in the death of 21000 to 143000 people yearly most of the fatalities being children. This highlights the importance of the development of disease-combating tools like vaccines.


source: microbewiki

Using immune-informatics methods, the researchers created a novel multi-epitope peptide vaccine that incorporates the cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and linear B lymphocyte (LBL) epitopes. The ability of the developed vaccine to induce immunological responses after the injection was established using ​​physicochemical, molecular docking, and thermodynamic stability profiling approaches. The design has an estimated half-life for mammalian reticulocytes in vitro of 4.4 h, a theoretical PI of 6.09, and a molecular weight of 53.85 kDa. To test for compatibility and efficacy, the vaccine’s design was docked against the human toll-like receptor (TLR). In vitro and in vivo research will be conducted shortly after this in silico study to corroborate it and to ensure the immunogenicity, wholesomeness, and safety of the proposed vaccine. ​​other post-vaccination assessments were carried out and the full analysis and result of the construct can be found in the publication


source: CDC

The institute has been on quite a roll over the past year as it has published research on the development of vaccine candidates for several diseases many of which are in different stages of trials and production.

Researchers at Helix Biogen institute have successfully created a diagnostic kit peptide for the early detection of loiasis. The disease which is caused by Loa loa filaria affects over 10 million people across Africa and is mainly diagnosed using serological testing which is not standardised. This method takes time and results in hindrances to adequate treatment of the disease. The extensive use of filaricidal medications in Onchocerca volvulus and Wuchereria bancrofti eradication programs led to the discovery that concurrent L loa infection increased the risk of serious, perhaps fatal treatment-related consequences. Therefore there is a need for the development of a rapid diagnostic test kit for quick detection of the infection.

[img]https://lh6.googleusercontent.com/kkEaPQi5XCc4cWyPq2aGsBdVMkQScnYRTZuhi_CXzJ0iG95njVE_AxfjEV24Cn1SMThw7BRx7Ie8hnBVrFO7Xwjiz7JcgFkkTUIMmoKio9Auj1hO_VbFmLmPkmrttg31Bq8a-qn760DF6De0FfI4u4-Gojaukf31pmBKykze1ACDVujLtjOcEeFNaJHLcg[/img]

The researchers did this by using antigenic genes of the filaria, thereby ensuring optimal antibody prediction. Bioinformative results of the physicochemical properties of the candidates are promising with The protein’s theoretical PI, aliphatic index, and GRAVY values being 8.14, 62.88, and -0.176, respectively. Further results can be seen in the publication.

[img]https://lh3.googleusercontent.com/LZX8gE1Q4L9nP_6rYgq_FgeLLtsRg-Go95JlAYacVZUPYDsXzVlALuCY7lyfBB7o-F2tCpbkFDybITxlqFP8mUFGkP7zcvGnTEX8Vg1rvCoeIzRm5xM11IjyihgIRp5sy2AoBOKu0zOOgUsMpPXM7gEnVJM91eA5jU5IoE88Gjhj6hEMH7YB3rtzSFklcg[/img]

This peptide provides a good template for constructing a rapid diagnostic test kit for loiasis infection and with the right investment can help in combating this tropical disease. It should be noted that the institute had earlier worked on a multi-epitope SARS-CoV 2 vaccine candidate which was indexed by WHO.

To read more, Go to globestand.

Bluezy13:



Hmmm...


Is there an existing WhatsApp group ??

I dontvknow of any

Bluezy13:


My dear, let them start o.


I need a place that food, shelter and transportation will not be a problem.
Don't want distractions while focusing on life after service.
About how much do you think I should budget for transportation fare ??

We are going from different places, mine is from Abeokuta and transport is 12k

Bluezy13:



Calabar to Taraba

Mbok, Taraba state dey give allowee

They used to give, then they stopped, they will start again because of me IJN.
But the place dey close to your side sha

Y

Taraba from Ogun anyone?

Hello, house, please I'm I the only one experiencing this 'error, please try again later' message from remita while trying to make payment

hizmail:
Observation please!!! There is no polling exercise on Tuesday 2nd Oct 2018 throughout d state yesterday pls confirm

There was, it was generally peaceful. Though the other candidates most especially dapo abiodun boycotted. They somehow knew before the election that ballot papers would be brought in from abj and told their followers not to go out. the party leadership in the state were not aware and went on with preparations for A4. Ballot papers eventually came for real, but it wasn't supposed to be so because APC guidelines state that ballot is to be used only in indirect primaries while A4 should be used in direct. Meanwhile the gov wanted indirect in the first place but instructions came from ABJ for it to be direct.
Schools were even closed impromptu when the nwc said they were ready only to change mouth.
NWC seems to be toying with the party leadpostponing and changing instructions and this has led to suspicions
The main battle is between dapo abiodun (and he is from ijebu) and the gov candidate from yewa. By zoning principle the next gov should be from yewa, but it has been flouted in the past so it might not hold
N.b I'm not a party member just someone who is in the state and knows what is going on

mudiana:
guys see wat I saw on naira land . try commenting D U L L A R D IN HO together, it will change to president buhari. I just tried it now. Lol! Nsiraland is d best.

President Buhari

modified: lol na true

the number of ribs is the determinant

This tread also doubles as my trading journal

i didn't know they've started having issues like this, i used to use them well before but i didn't have reason to use them for a while so i just went to the site straight when i wanted to use it now

DAYTEECOM:
why giving urself stress when [url]smedata.com.ng[/url]can give you the best

hello, i've been trying to withdraw the 2700 naira in my account using the transfer option but i'm always getting a message saying i maximum i can transfer is 0.00 naira, what is going on and how do i withdraw my money, customer care number is not connecting

hello, i've been trying to withdraw the 2700 naira in my account using the transfer option but i'm always getting a message saying i maximum i can transfer is 0.00 naira, what is going on and how do i withdraw my money, customer care number is not connecting

08176221697

Pls I need placement for 3 months it, microbiology, Bowen university, pls contact oladunnidave.t@gmail.com

Nice prog, questions were okay, couldn't finish though, ran out of time @ no 30-something, ended up with 42%. Nice concept though.

Oladunnidave.t@gmail.com
Bowen university
Microbiology
300 lvl

pseudomonas:

we do training and research. the internship here isn't paid at all and mostly for undergraduates

I will be doing my IT soon and it sounds like your institution is purely about microbiology, how can I apply for IT?

Niwdog:
What's wrong with FPL? On there injury update, Defoe was reported to be injured, that's was why I benched him but some how he played and annex 13point. I benched blind who got 10point, why I get badluck like this?

Same here o, benched Defoe cause of that injury stuff and he played, whereas negredo came up with 1 point, thanks for Capt aguero.

debosky:
Any more h2h league places available?

#latecomer

If you find abeg halla me, I dey find too

[quote author=sammysunny88 post=49627853] word!! Pls I want to know you, moving with the right pple begins like this 08176221697

Neisseria gonorrhoeae, the bacteria responsible for gonorrhea. (Image: National Institute of Biomedical Imaging and Bioengineering)
Health officials in the US have identified a cluster of gonorrhea infections that exhibited unusual resistance against the last two main antibiotics known to work against the dreaded sexually transmitted disease.

The unusually resilient cluster of gonorrhea infections, which were discovered in Hawaii, exhibited decreased susceptibility to ceftriaxone and a very high-level resistance to azithromycin—both of which are used as frontline drugs (i.e. the first and often most effective drug of choice for a given treatment). Together, these two antibiotics make up the dual regimen that’s the last available effective gonorrhea treatment option.


Earlier this year, health officialssounded the alarm when they discovered a strain of gonorrhea that had developed resistance to azithromycin, but not ceftriaxone. The Centers for Disease Control and Prevention says this new cluster is the first in US to show such dramatically reduced susceptibility to both frontline drugs.
“Our last line of defense against gonorrhea is weakening,” noted Jonathan Mermin, a director at the US Centers for Disease Control and Prevention, in a statement. “If resistance continues to increase and spread, current treatment will ultimately fail and 800,000 Americans a year will be at risk for untreatable gonorrhea.”
This common sexually transmitted disease is caused by the Neisseria gonorrhoeae bacterium, and it infects both men and women. Symptoms of gonorrhea include a greenish yellow or whitish discharge from the penis and vagina, burning while urinating, swollen glands in the throat (due to MouthAction), among others. If left untreated, it can cause serious health problems such as infertility, pelvic inflammatory diseases, and life-threatening ectopic pregnancy in women (when the fetus develops outside the uterus).
The highly resistant strain was isolated from seven individuals in Honolulu in April and May of 2016, and these infections all showed resistance to both azithromycin and ceftriaxone. All patients were treated successfully, but the level of resistance was disturbing.
“Hawaii is on the front line for antibiotic-resistant gonorrhea—we’ve been one of the first states to see declining effectiveness of each drug over the years,” noted Alan Katz, a public health official at the University of Hawaii. “That’s made us extremely vigilant, so we were able to catch this cluster early and treat everyone found who was linked to the cluster. But the future risk of gonorrhea becoming resistant to both of the recommended therapy medications in the United States is troubling.”
On a positive note, an experimental oral antibiotic, called ETX0914, is currently under development, but it could be years before it reaches clinical trails. And even if it does prove effective, it may only be a matter of time before it too becomes ineffective in the face of this ever-evolving bacterial infection.
http://www.globestand.xyz/2016/09/gonorrhoea-bacteria-is-becoming.html?m=0#links

More stories
http://www.globestand.xyz/2016/09/10-deadly-diseases-that-are-coming-back.html?m=0

UC Berkeley scientist Dr. Joel Moskowitz believes that the usage of AirPods may want to reason customers brain harm. Even though Apple surpassed FCC requirements for suited radiation tiers, Moskowitz nonetheless believes that brain damage is viable. The idea of Bluetooth radiation causing mind damage or being a fitness threat isn’t new and it has been debated on and off over time. Mobile phone usage continues to be hotly debated and some remember their use probably harmful.


“we're gambling with fireplace right here,” Dr Joel Moskowitz, a professor on the UC Berekely faculty of Public fitness, advised daily Mail on line. “you are putting a microwave-emitting tool next to your mind. This has been observed over several many years, he says. It’s like we hold rediscovering that Bluetooth is harmful and looking to overlook it because we don’t know the way to cope with it from a policy viewpoint. Although we don’t understand the lengthy-term dangers from the use of Bluetooth devices, why would every person insert microwave-emitting gadgets of their ears close to their mind whilst there are more secure ways to apply a cell cellphone? Basically I advise the use of corded headsets or arms-unfastened use of cellular phones, not wireless ear buds.”

this is one of those troubles wherein distinctive scientists produce conflicting outcomes and there are various thoughts of what's harmful and no longer. Moskowitz’s end might no longer best observe to Apple’s AirPods however also each Bluetooth headset in the marketplace. All of them paintings in a similar fashion yet they’ve all been surpassed by way of the FCC. So who do we believe in this example? The FCC is meant to have our nicely being at the leading edge of their minds so that you could suppose their judgement to be pretty stable. However scientists like Moskowitz make valid arguments and that i wager it'll take extra studies and debate to perhaps settle this dispute

http://www.globestand.xyz/2016/09/airpods-may-cause-brain-damage.html?m=1

Fp

Baboo13:
Worst GW ever

Chai

As in, first time I'm getting below the week's average.
I'm a first timer though so i get excuse

semasir:
Okay.... It's semasirconnect@gmail.com

I've sent it, thanks

nonsso:
who plays uefa fantasy football here??

I do, first time though

semasir:
Got your mail and responded.

M'sorry, but I didn't see it, maybe you should pls resend