₦airaland Forum

Harrisibor:
don't understand you oooo. Why should I contact u pls

Harrisibor:
rhythmskul@yahoo.com

nicko92:
By Ellie Zolfagharifard
12:35 22 Jul 2014, updated 16:59 22 Jul 2014
Scientists used a DNA-snipping enzyme
called Cas9 to cut out the virus
The cell's gene repair machinery then
takes over, soldering the loose ends of the
genome back together – resulting in a
virus-free cell
Process could also be a cure for other
latent infections, researchers say
'It's an exciting discovery, but not ready
to go into the clinic,' said Dr Khalili
Once HIV conquers a human cell, it will stay
there forever.
It inserts its deadly genome permanently into its
victims' DNA, forcing them to require medical
treatment for the rest of their life.
But now, for the first time, researchers in
Philadelphia have found a way to completely
delete HIV from human cells by ‘snipping’ them
out.

The team of Temple University School of
Medicine said the breakthrough marks the first
successful attempt to eliminate latent HIV-1
virus from human cells – and could be a cure for
other latent infections.
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‘This is one important step on the path toward a
permanent cure for AIDS,' said Kamel Khalili,
PhD, Professor and Chair of the Department of
Neuroscience at Temple.
'It's an exciting discovery, but it's not yet ready
to go into the clinic. It's a proof of concept that
we're moving in the right direction,' he added,
Temple University makes promising steps
towards cure for HIV
In a study published by the Proceedings of the
National Academy of Sciences, Dr Khalili and
colleagues detail how they created molecular
tools to delete the HIV-1 proviral DNA.
HOW THE PROCESS WORKS
Researchers based the two-part HIV-1 editor on
a system that evolved as a bacterial defence
mechanism to protect against infection.
When deployed, a combination of a DNA-snipping
enzyme called a nuclease and a targeting strand
of RNA called a guide RNA (gRNA) hunt down
the viral genome and remove the HIV-1 DNA.
Dr Khalili's lab engineered a 20-nucleotide strand
of gRNA to target the HIV-1 DNA and paired it
with a DNA-sniping enzyme called Cas9 and
used to edit the human genome.
From there, the cell's gene repair machinery
takes over, soldering the loose ends of the
genome back together – resulting in virus-free
cells.
When deployed, a combination of a DNA-snipping
enzyme called a nuclease and a targeting strand
of RNA called a guide RNA (gRNA) hunt down
the viral genome and remove the HIV-1 DNA.
From there, the cell's gene repair machinery
takes over, soldering the loose ends of the
genome back together – resulting in virus-free
cells.
'Since HIV-1 is never cleared by the immune
system, removal of the virus is required in order
to cure the disease,' explained Dr Khalili.
These molecular tools also hold promise as a
therapeutic vaccine; cells armed with the
nuclease-RNA combination proved impervious to
HIV infection.
Worldwide, more than 33 million people have
HIV, including more than 1 million in the United
States.
Every year, another 50,000 Americans contract
the virus, according to the U.S. Centers for
Disease Control and Prevention.
In the UK, around 100,000 people were living
with HIV in the UK in 2013. That’s around one
person in 665.
Although highly active antiretroviral therapy
(Haart) has controlled HIV-1 for infected people
in the developed world over the last 15 years, the
virus can rage again with any interruption in
treatment.
'The low level replication of HIV-1 makes
patients more likely to suffer from diseases
usually associated with ageing,' Dr Khalili said.
These include cardiomyopathy – a weakening of
the heart muscle – bone disease, kidney disease,
and neurocognitive disorders.
'These problems are often exacerbated by the
toxic drugs that must be taken to control the
virus,' Dr Khalili added.
Researchers based the two-part HIV-1 editor on
a system that evolved as a bacterial defence
mechanism to protect against infection.
Dr Khalili's lab engineered a 20-nucleotide strand
of gRNA to target the HIV-1 DNA and paired it
with a DNA-sniping enzyme called Cas9 and
used to edit the human genome.
'We are working on a number of strategies so we
can take the construct into preclinical studies,'
Dr Khalili said.
'We want to eradicate every single copy of HIV-1
from the patient. That will cure AIDS. I think this
technology is the way we can do it.

suxes2005:
The person will send it through mail or e-mail and you
will redeem it by collecting it at the post office or DLin
from your e-mail.

~ Sheyi

suxes2005:
Hi all,

Each time anyone calls me either from NL or
from referral and I tell them to try the United States
they think its the hardest visa to get in life but this
is not true.

I will like anyone interested in going to usa as a visitor
to state his or her interest here so that i can show you
the way to go about it right here, we will all see the
result of the application here.

I just helped a friend of my pastor to secure his through
searching for pastor's conference for him,



SHALOM

VisaOfficer:
Good morning, everyone! It looks like our previous thread was a casualty of the recent data loss, so I'm starting a new thread here. Nairaland, I missed you and am glad you're back!

I am a U.S. Foreign Service Officer working at the U.S. Consulate in Lagos, Nigeria, primarily handling Immigrant Visas and Diversity Visas (IVs and DVs). The purpose of this thread is to provide a forum for your questions about these types of visas. My colleagues and I will make every effort to answer all questions within two business days.

Please note that we cannot answer questions about specific cases, except as based on the information provided here in this discussion thread. Any responses in this forum are not to be taken as legally binding, as they will be based only on what you tell us in your questions, not on the information in any actual case. While we will attempt to explain U.S. immigration policies, any opinions expressed are the personal views of the writer, and do not necessarily reflect the views of the United States Government.

We may not be able to respond to every post in this thread, and we will not answer abusive posts. Also, please don't send me private messages -- I don't even read them. If you need personal attention, please send an e-mail to LagosIV@state.gov.

There is a separate thread for Non-Immigrant Visa Questions, also handled by U.S. Foreign Service Officers serving in Nigeria, at https://www.nairaland.com/1792662/u.s-non-immigrant-visas-listening . Please use this thread right here solely for questions about Immigrant Visas and Diversity Visas.

All the best,
VisaOfficer

saibinc: Are you able to browse on the phone using other applications apart from Playstore, facebook and gmail?

saibinc: Are you able to browse on the phone using other applications apart from Playstore, facebook and gmail?

saibinc: @HTC1: If you have custom ROM on your HTC1, then you need to re-flash the exact Google Gapps for the version of that HTC1.
E.g if the HTC1 is android 4.4.4, you need flash the earliest google apps/Gapps on the phone.
View this page for details about Gapps and downloads: http://www.arykblog.com/2014/03/what-is-gapps.html

However, if the ROM on the HTC1 is a Stock ROM (the ROM that comes with the Phone), download Mobogenie then,use mobogenie to update your Google Play Service and the Playstore then restart your phone.

@LG: As for the LG, does the phone hits up? If yes, backup the phone contents and perform a full wipe on the phone. If you know more about engineering android phones, I suggest that you change the phone's recovery to 4EXT or[b] TWRP [/b]recovery.
Most android devices charge from the recovery and changing the recovery could be a lasting solution -It is a tested and confirmed solution on HTC, Samsung and Motorolla android phones. Although, I have not done it on LG, I believe that would work for it too.

saibinc: Download Mobogenie on the phone and grant it root access. Download and install apps from mobogenie and try them. Those apps should work once root access is granted to mobogenie.