Can some please explain to me. My friend wife just delivered a bouncing baby boy and doctor confirm the the boy has SC. I want to know is it the same as SS.

Sometimes Google is your best friend



The AS AC SC SS and CC genotype.

What you have in your blood are cells, the most predominant of which are called RED BLOOD CELLS (RBCs).
These cells contain within them HEMOGLOBIN, a substance without which the RBCs are invariably useless.
This hemoglobin itself is composed of 2 parts: a heme (don't bother yourself, this basically is a complex Iron-protein complex) and globin (2 pairs of protein chains, this is the important part).
There are 2 alpha and 2 beta globin chains - the pair, and there is a normal way the chains are supposed to be structured.
The error happens when a protein substitution occurs in any one of these chains - but particularly in the globin chains (First of all, you have to understand that amino acids are the building blocks of proteins - so if amino acid 'x' is the normal, an abnormality occurs when instead of 'x' at a particular location along the chain, you have 'y'.)

That is as simple as it gets. These errors of substitution are given the big name of 'THALASSAEMIAS'. In reality, a substitution will occur at any point along either the alpha or beta chains but for the purposes of simplicity and to answer your question, we focus on the genotypes AS, SS, AC.
Genotype AA: At position 6 of both globin chains,the amino acid is GLUTAMATE
Genotype AS: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have VALINE
Genotype SS: At position 6 of both globin chains, the amino acid is VALINE
Genotype AC: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have LYSINE

There are different types of Hemoglobin; among them are Hemoglobin A, Hemoglobin S and Hemoglobin C.
Hemoglobin C is very rare.
Everyone must have a pair of these hemoglobin in their blood, each inherited from both parents.
The pairing might be in any of the following formations: AA, AS, AC, SC,SS OR CC.
A man with AA can marry anyone without any problem (medically); likewise the woman.

How do people get their genotypes?
Simple, from your biological parents.
If papa bomboy has a genotype AA and mama bomboy has a genotype AS, which genotype do their children have?
What we do in theory is this, you cross each of those letters so that you have AA, AS, AA, AS? Therefore, for each pregnancy and each bomboy they delivery has a 50:50 probability of being AA or AS.
What if their genotypes were AA (for papa bomboy) and SS (for mama bomboy); you do the crossing again: AS, AS, AS, AS. Therefore, it is very UNLIKELY that any of their children will have a genotype outside of AS.
You will see that I have used the word unlikely because poo happens. They might end up having a child who is either completely AA or SS but whatever happens, a child's genotype is never outside of the parents. Eg. a man and woman who are both AA can never have children with genotype starting or ending with 'S'. If it happens, either your landlord or next door neighbours are highly involved (just kiddin Oluwa isn't involved').
So for you to get C, you must have a parent who carries a 'C' in his or her genotype.
Likewise the S must have a parent with S genotype
One more thing: Are there any clinical features of Hemoglobin C like Hemoglobin S?

In the case that you're AC, well the good news is that MOST TIMES THERE ARE NO SYMPTOMS, but occasionally, there is JAUNDICE.
THE BEST PART IS THAT YOU CAN LIVE A NORMAL LIFE WITH AC!!!
And just for the case of mentioning genotypes, you could have:
Regular Genotype: AA (healthy as healthy can be)
Traits: AC, AD, AF, AG, A+FAST, AE and AS (not associated with any clinical signs, symptoms or syndromes - they as relatively as healthy as AA)
Genotypes associated with clinical features: SS, SC, CC (are associated with clinical signs, symptoms and syndromes)

•Please note that the marriage thing is this, we really don't know what the recent trend is but the important thing is to make sure your genotype of you and your partner don't match up in a way as to pro



https://m.facebook.com/LAUMSITESYWC/posts/668789426506335

Thanks for the info!

strangest:
Sometimes Google is your best friend



The AS AC SC SS and CC genotype.

What you have in your blood are cells, the most predominant of which are called RED BLOOD CELLS (RBCs).
These cells contain within them HEMOGLOBIN, a substance without which the RBCs are invariably useless.
This hemoglobin itself is composed of 2 parts: a heme (don't bother yourself, this basically is a complex Iron-protein complex) and globin (2 pairs of protein chains, this is the important part).
There are 2 alpha and 2 beta globin chains - the pair, and there is a normal way the chains are supposed to be structured.
The error happens when a protein substitution occurs in any one of these chains - but particularly in the globin chains (First of all, you have to understand that amino acids are the building blocks of proteins - so if amino acid 'x' is the normal, an abnormality occurs when instead of 'x' at a particular location along the chain, you have 'y'.)

That is as simple as it gets. These errors of substitution are given the big name of 'THALASSAEMIAS'. In reality, a substitution will occur at any point along either the alpha or beta chains but for the purposes of simplicity and to answer your question, we focus on the genotypes AS, SS, AC.
Genotype AA: At position 6 of both globin chains,the amino acid is GLUTAMATE
Genotype AS: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have VALINE
Genotype SS: At position 6 of both globin chains, the amino acid is VALINE
Genotype AC: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have LYSINE

There are different types of Hemoglobin; among them are Hemoglobin A, Hemoglobin S and Hemoglobin C.
Hemoglobin C is very rare.
Everyone must have a pair of these hemoglobin in their blood, each inherited from both parents.
The pairing might be in any of the following formations: AA, AS, AC, SC,SS OR CC.
A man with AA can marry anyone without any problem (medically); likewise the woman.

How do people get their genotypes?
Simple, from your biological parents.
If papa bomboy has a genotype AA and mama bomboy has a genotype AS, which genotype do their children have?
What we do in theory is this, you cross each of those letters so that you have AA, AS, AA, AS? Therefore, for each pregnancy and each bomboy they delivery has a 50:50 probability of being AA or AS.
What if their genotypes were AA (for papa bomboy) and SS (for mama bomboy); you do the crossing again: AS, AS, AS, AS. Therefore, it is very UNLIKELY that any of their children will have a genotype outside of AS.
You will see that I have used the word unlikely because poo happens. They might end up having a child who is either completely AA or SS but whatever happens, a child's genotype is never outside of the parents. Eg. a man and woman who are both AA can never have children with genotype starting or ending with 'S'. If it happens, either your landlord or next door neighbours are highly involved (just kiddin Oluwa isn't involved').
So for you to get C, you must have a parent who carries a 'C' in his or her genotype.
Likewise the S must have a parent with S genotype
One more thing: Are there any clinical features of Hemoglobin C like Hemoglobin S?

In the case that you're AC, well the good news is that MOST TIMES THERE ARE NO SYMPTOMS, but occasionally, there is JAUNDICE.
THE BEST PART IS THAT YOU CAN LIVE A NORMAL LIFE WITH AC!!!
And just for the case of mentioning genotypes, you could have:
Regular Genotype: AA (healthy as healthy can be)
Traits: AC, AD, AF, AG, A+FAST, AE and AS (not associated with any clinical signs, symptoms or syndromes - they as relatively as healthy as AA)
Genotypes associated with clinical features: SS, SC, CC (are associated with clinical signs, symptoms and syndromes)

•Please note that the marriage thing is this, we really don't know what the recent trend is but the important thing is to make sure your genotype of you and your partner don't match up in a way as to pro



https://m.facebook.com/LAUMSITESYWC/posts/668789426506335

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