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Nairaland Forum / Nairaland / General / Health / The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) (22243 Views)
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The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Dentalgist: 10:16am On Oct 08, 2019 |
The Chinese in the mid-60’s made a concerted effort to find an effective antimalarial. Chinese scientists searched for effective antimalarials from both modern drugs and their ancient medicines. Project 523 was initiated on 23 of May 1967 for this purpose. It was a multicentre collaboration and led to the discovery of a new drug from the Chinese plant Artemisia annua . This plant has been used since ancient times for fever. Organic extracts of the leaves of Artemisia annua were thoroughly studied. Scientists gradually identified substances that had antimalarial properties, determined their chemical structures, and characterized their physico-chemical properties. Antimalarial properties of various chemical structures were tested in animal models of malaria and then in human malaria. One great discovery, qinghaosu which was later called artemisinin, produced the most effective and the most rapid clearance of malaria parasites ever observed for any known drug. It was isolated in 1972 from the leaves of the traditional medicine Artemisia annuaand was found powerful against Plasmodium falciparum. Experts in chemistry labored to alter the molecule of qinghaosu by chemical reduction to produce dihydroqinghaosu (dihydroartemisinin) and this semisynthetic drug was even a more potent antimalarial. More chemical modification were made to make it more oil soluble, yielding arteether and artemether and more water soluble, yielding artesunate and artelinic acid. Artemether and artesunate as stable analogues have become popularly used drugs. However it took numerous laboratory studies and clinical trials to reach this stage. Professor Li Guo Qiao, a professor of traditional Chinese medicine from Guangzhou led extensive clinical trials that revealed the effectiveness of these drugs in both uncomplicated and cerebral malaria. In 1979 the Qinghaosu Antimalaria Coordinating Research Group published in English the physicochemical properties, antimalarial activity, and clinical evaluation of artemisinin in the Chinese Medical Journal. The 2015 Nobel Prize for Medicine or Physiology was awarded to William C. Campbell and Satoshi Ômura for their discovery of avermectins, and to Tu You You for her contribution to the discovery of artemisinin. The biological activity of artemisinin and its derivatives is due to the reactivity of an endoperoxide bridge in their molecular structure. Artemisinin derivatives are fast drugs, cause rapid clearance of the malaria parasites from the blood and produce rapid recovery from malaria symptoms. Because the drugs are metabolized by liver enzymes and removed from the body fast, another drug must be used that has a slower onset of action and longer duration of action and will complete the clearance of remaining parasites such a hypnozoites in tissues after the first 48 hr, hence the use of artemisinin based combination therapies (ACTs). Artemisinin and its derivatives are generally not used in monotherapy. Artesunate given orally in combination with another drug is used for uncomplicated malaria. However, intravenous artesunate (AS) and intramuscular artemether (AM) are clearly effective in reducing incidences of malaria deaths around the world. Artesunate is a prodrug that is rapidly converted to its active form dihydroartemisinin (DHA) within the human body. Artesunate, because of its solubility can be formulated as oral, rectal, intramuscular, and intravenous pharmaceutical preparations making it useful for severe and complicated malaria where different routes of administration are needed. Artesunate injection is used for severe malaria in hospitalized patients. It is active against various malaria parasites including against P. ovale, P. malariae, and P. knowlesi. Artesunate is on the World Health Organization’s List of Essential Medicines, which are considered effective and safe medicines needed in the health system. https://dentalgist.ng/the-story-of-the-magical-antimalarial-chinese-medicine-ginghaosu-artemisinin 13 Likes 1 Share
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Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Nobody: 1:23pm On Oct 08, 2019 |
is there any difference between artesunate and arthemeter? |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by FlyACT: 2:33pm On Oct 08, 2019 |
Torching 1 Like |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Yukyaky: 2:33pm On Oct 08, 2019 |
Wow great 1 Like |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by baby124: 2:34pm On Oct 08, 2019 |
Malaria, the one thing causing Oyinbo to fear invading Africa. It’s like HIV to them . Reason why they are desperate to HELP us find a cure 44 Likes 1 Share |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Davgii: 2:34pm On Oct 08, 2019 |
Life |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Elolam88: 2:34pm On Oct 08, 2019 |
1 Like 1 Share |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Thunday1005(m): 2:35pm On Oct 08, 2019 |
1 Like 2 Shares |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Sirseedorf(m): 2:35pm On Oct 08, 2019 |
Now that's a serious country. |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by VillageHead: 2:35pm On Oct 08, 2019 |
Magic wetin! So all dis long tori be say dis meresin beta pass our 'Agbo?' You don try Ijebu, Ibadan or I sogbo Agbo? 2 Likes 2 Shares |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by sinaj(f): 2:35pm On Oct 08, 2019 |
Just like agbo leaves 1 Like |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by sentorial: 2:36pm On Oct 08, 2019 |
Story for the gods. |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by bikerboy1(m): 2:36pm On Oct 08, 2019 |
So there's malaria in China |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by PureGoldh(m): 2:37pm On Oct 08, 2019 |
Nice write-up |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by flyca: 2:37pm On Oct 08, 2019 |
This is what we all need to understand in Africa! However it took numerous laboratory studies and clinical trials to reach this stage. Research brings solutions not Religion. On another note - Please is there any smart, reliable female UNIZIK student who can help me go make some enquiries in an office in Awka for a token, pls send me a PM. Thank you 7 Likes 1 Share |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by naijadrivablog: 2:37pm On Oct 08, 2019 |
"Magical" you say It depends on the type of malaria. E get malaria wey go hold you, you go drink this ACTs tire. 2 Likes |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by okirewaju(f): 2:40pm On Oct 08, 2019 |
Na wa The writeup is making my eyes turn on its own |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by tillaman(m): 2:41pm On Oct 08, 2019 |
Malaria get levels ooo!! |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by RealGOAT: 2:41pm On Oct 08, 2019 |
As if you know am down with malaria now, a disease i can't avoid every month. 1 Like 1 Share |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by YorubaNinja: 2:41pm On Oct 08, 2019 |
sentorial: Baba nla Ignorance! 1 Like |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Dottore: 2:42pm On Oct 08, 2019 |
Ok |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by agabaI23(m): 2:42pm On Oct 08, 2019 |
aminu114:one is a methyl ester and the succinate ester. |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by deolumike(m): 2:43pm On Oct 08, 2019 |
Instead of all this long process of chemical synthesizing. Why not simply cook the leaves of the plant and drink as agbo? (Concoction) Na idea. See signature and patronize. |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Nobody: 2:46pm On Oct 08, 2019 |
agabaI23:ok which one is more effective cuz im down with malaria |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by deolumike(m): 2:46pm On Oct 08, 2019 |
okirewaju:you need new glasses. FlyACT:touching 1 Like |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by nwabobo: 2:47pm On Oct 08, 2019 |
aminu114: No. |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Jossyroyal1: 2:48pm On Oct 08, 2019 |
Impressive Check my signature |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by bestman09(m): 2:50pm On Oct 08, 2019 |
Re: The Story Of The Magical Antimalarial Chinese Medicine – Ginghaosu (Artemisinin) by Kaybaba5(m): 2:52pm On Oct 08, 2019 |
They should help us to look for drugs to cure hiv |
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