www.ngrguardiannews.com/2015/04/herbal-cures-for-lung-cancer-malaria-validated/


NIGERIANS and indeed people from all races need not die
from cancers and malaria any longer.

United States and Nigerian researchers have, in two recent
but separate studies published in reputable medical
journals, validated the use of local herbal drugs for the
treatment of lung cancer and malaria.

The basic constituents of the herbal drugs SAABFAT6 and
SAABMAL include: garlic (Allium sativum), lemon grass
(Cymbopogon citratus), bitter leaf (Vernonia amygdalina),
sugarcane (Saccharum officinarum), green vegetable/
Amaranth (Amaranthus caudatus), Aloe vera (Aloe
barbadensis) and sesame (Sesamum indicum).
United States researchers from Texas Southern University,
Houston, Texas, found that a Nigerian-made herbal
supplement, SAABFAT6, have potential for the regulation the
growth of colorectal and lung cancer.

SAABFAT6 has been registered by the National Agency for
Food Drug Administration and Control (NAFDAC).
The study published in April 2015 editions of The FASEB
Journal and Experimental Biology is titled “Antiproliferative
and Cytotoxic Evaluation of Herbal Supplement SAABFAT6
on HT29 Colorectal Adenocarcinoma Cells.”

The researchers, Syntia E Kwende and Momoh A Yakubu,
who recently presented their findings at the American
Society for Pharmacology and Experimental Therapeutics
(ASPET) yearly scientific meeting concluded:

“The consumption of herbal supplements has been one of the
remedy for several aliments including cancer for a long time.
Cancers, especially colorectal adenocarcinoma are diseases
with high morbidity and mortality and are often associated
with suffering and poor quality of life.

“Herbal supplements are an attractive cancer therapy, we
have investigated the antiproliferative and cytotoxic
properties of the herbal supplement SAABFAT6 on colorectal
adenocarcinoma cell (HT29). Ethanol extracts of SAABFAT6
(0.5-2 mg/mL) was incubated with HT29 and in vitro
antiproliferative/cytotoxicity activities were evaluated using
MTT assay.

“Treatment of HT29 with SAABFAT6 significantly reduced
cellular proliferation at 48 and 72 but not at 24 hours
except for 2 mg/mL concentration. Cytotoxic evaluation
showed significant reduction in cell viability at 24 and 48
hrs (2 mg/mL) and at 48 hours (0.5 and 1 mg/mL). This
preliminary result indicates that SAABFAT6 supplement may
have a potential for the regulation of HT29 growth and
survival.

Further study is required to identify the mechanisms by
which the anti-proliferative and cytotoxic effects of
SAABFAT6 is mediated.”

Also, Nigerian researchers from the Departments of
Pharmacology & Toxicology and Pharmaceutical Technology
& Raw Material Development, NIPRD and Halamin Herbal
Centre, Abuja, have demonstrated the efficacy of SAABMAL,
a local herbal drug, as a herbal antimalarial formulation
against chloroquine sensitive malaria and its potential use
in the treatment of uncomplicated malaria infection.

The study published in February 2015 edition of Indian
Journal of Medical Research is titled “Antimalarial
properties of SAABMAL: an ethnomedicinal polyherbal
formulation for the treatment of uncomplicated malaria
infection in the tropics.”
The researchers led by Prof. Martins Emeje of NIPRD
include I.C. Obidike and Ben Amodu of Haalamin Herbal
Centre Abuja.

They concluded: “In conclusion, our results confirmed the
efficacy of SAABMAL® as an herbal antimalarial formulation
with acceptable capsule qualities. However, there is a need
for development of an appropriate analytical technique for
monitoring drug release from the formulation.

This will assist in developing appropriate stability parameters and bioavailability/bioequivalence studies during clinical trials.”
Amodu who is also the director and chief researcher of the
Centre said the study showed that SAABMAL is a remedy
for cancer. The phytho-medicinal researcher also added
that his products when taken to America had been found
out to have curing capacity of over 75 per cent of both
cancers of lung, colon, and pancreas, among others.

Malaria is a serious problem in the countries of the
developing world. As the malaria parasite has become
resistant to most of the antimalaria drugs available
currently, there is a need to search for newer drugs.
This study reported the pharmaceutical quality and in vivo
antimalarial activities of a polyherbal formulation
(SAABMAL®) used as malarial remedy in Nigeria.
The antiplasmodial activity of SAABMAL® was determined by
using the four-day suppressive test in Plasmodium berghei-
infected mice.

The formulation was tried on three different
experimental animal models for in vivo antimalarial
activities, which are prophylactic, suppressive and curative
in mice. Chloroquine and pyrimethamine were used as
standard drugs for comparison.

The suppressive study showed that, SAABMAL® (200 and
400 mg/kg/bw) significantly produced a suppression (29.39
to 100 per cent) of parasitaemia in a dose-dependent
manner, while the curative study showed that SAABMAL® at
400 mg significantly reduced (95.80 per cent) parasitaemia
compared with controls.
The mean survival time of SAABMAL®-treated groups (100
and 200 mg/kg) was higher than that of the chloroquine-
treated group.
The researchers found no changes in the spleen of both
untreated and treated groups. SAABMAL® capsules were of
good mechanical properties with low weight variation and
high degree of content mass uniformity.

They wrote: “The results obtained in this study showed the
efficacy of SAABMAL®, a herbal antimalarial formulation
against chloroquine sensitive malaria and its potential use
in the treatment of uncomplicated malaria infection.
Further studies need to be done in humans to test its
efficacy and safety for its potential use as an antimalarial
drug.”

Malaria is a problem in every region of the developing world
and contributes significantly to mortality, poverty and
underdevelopment in endemic regions1. The problem is
greatest in Africa, where over 80 per cent of malaria cases
and death occur.

View the complete list of approved drugs that cure malaria from here http://www.edumacro.com/malaria-treatment-prevention/