I am writing an application which will read the coordinates from a GPS into a .Net program, please how do I do that. The GPC to computer interface is USB but other options available. Please links are welcome too. Thanks.

Depend on your device type. For example my java enabled phone I can use Java API to get data from the GPS embedded in it.

dustydee:

I am writing an application which will read the coordinates from a GPS into a .Net program, please how do I do that. The GPC to computer interface is USB but other options available. Please links are welcome too. Thanks.

You have not stated the exact nature of your problem. Is it that you don't know where to start with communicating with a USB device? If so, you can use the generic native Windows USB driver (Winusb.sys).
If you are comfortable with C++, then this is a good resource:
http://msdn.microsoft.com/en-us/library/windows/hardware/ff540174(v=vs.85).aspx

If C# or VB.NET are your thing, you could try this wrapper lib around Winusb.sys:
http://code.google.com/p/winusbnet/

If you want infrared, bluetooth and objectExchange, try a really mature library like 32feet.NET (http://inthehand.com/content/32feet.aspx)

Thanks. What I want to do is retrieve the coordinates from the GPS(using the program) and then make use of it(i.e the coordinates).It's a location based app that requires the use of the coordinates.

This library should help you lots:
http://dotspatial.codeplex.com/wikipage?title=DotSpatial.Positioning

Thanks man, I will have a look at it.