scholes0:


Other research do exist on the subject matter.
Just search online.

Interesting. I'll check it out.

If I can find any academic scholarship from internationally recognised bodies to corroborate the hypothesis, I'll post it on the other side.

We have "eku eda'' (multimamate rats) in abundance in the south west. In fact I am still surprised it spreads lassa fever cos when I was very young we used to set traps to catch them and we handled them without caution.

looseweight:
Simply put that the specie of rat carrying the causative agent of lassa fever are rare in the southwest.

Overweight has been shown to be a predisposing factor of cardiovascular diseases. To loose excess fat from the body, check my profile or signature for great testimonies

scholes0:
.

Err, the hypothesis looks more plausible to me now. I just found an academic scholarship by Harvard University and it did corroborate the argument by this hypothesis about LARGE and IL21 genes being resistant to the Lassa Virus. However, it never mentioned Yorubas or any other group.

This is the scholarship: https://dash.harvard.edu/bitstream/handle/1/11248782/3267117.pdf?sequence=1

@scholes0

I just found another scholarship from Harvard that'd cite Yoruba, Esan, and Mende.

I'll post it now - I hope the spambot doesn't ban me.

cc: lalasticlala ...unban me if the spambot bans my next post.

Host Genetics and Human Adaptation to Lassa Hemorrhagic Fever in West Africa. S. Tabrizi1,2,3,10, R. Tariyal1,2,10, I. Shlyakhter1,2, S. F. Schaffner2, S. K. Gire1,2, M. S. Stremlau1,2, E. K. Karlsson1,2, K. G. Andersen1,2, E. Phelan2, L. M. Moses4, W. Omoniwa5, I. Odia5, P. E. Ehiane5, O. Folarin5,6, A. Tareila1,2, L. M. Branco4, J. S. Schieffelin4, D. Levy4,7, S. Gunther8, D. S. Grant7, G. O. Akpede5, D. A. Asogun5, P. O. Okokhere5, R. F. Garry4,11, C. T. Happi5,6,11, P. C. Sabeti1,2,9,11, Viral Hemorrhagic Fever Consortium 1) FAS Center for Systems Biology, Department of OEB, Harvard University, Cambridge, MA; 2) Broad Institute, Cambridge, MA; 3) Harvard Medical School, Boston, MA; 4) Department of Microbiology and Immunology, Tulane University, New Orleans, LA; 5) Institute of Lassa Fever Research and Control, Irrua Specialist Teaching Hospital, Edo State, Nigeria; 6) Department of Biological Sciences, College of Natural Sciences, Redeemer's University, Redemption City, Ogun State, Nigeria; 7) Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Sierra Leone; Lassa Fever Laboratory, Kenema Government Hospital, Kenema, Sierra Leone Department of Virology, Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany; 9) Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA; 10) These authors contributed equally to this work; 11) These authors jointly supervised this work.

Lassa virus has the unique status of being both one of the world’s deadliest pathogens, designated bio-safety level 4 (BL-4), and a public health crisis, endemic in large parts of West Africa. It is estimated to have originated over 1000 years ago in Nigeria, and a genome-wide survey of human variation identified the gene LARGE, biologically linked to Lassa virus infection, as among the strongest signals of natural selection in the Yoruba population of Nigeria. We pursued the hypothesis that Lassa virus is an ancient selective force, driving the rise of genetic resistance, by conducting a genome-wide association study (GWAS) of Lassa fever cases and controls in Nigeria and Sierra Leone. We report a signal of association at LARGE, and show that it overlaps with the previously reported signal of selection. This suggests recent evolution of resistance to Lassa fever in West Africa, making it one of only a handful of known loci under positive selection elucidated to be involved in resistance to infectious disease. Population genetics analysis provides further insights into the origins and spread of the resistance variant in LARGE. We show that the same putatively protective haplotype under selection in the Yoruba is also present in the Esan population of Nigeria and the Mende population of Sierra Leone. We find that the frequency is highest in the Yoruba (30%), lower in the Esan (21%) and the Mende (10%), and absent in East African and non-African populations (where Lassa fever is also absent). This is consistent with results from our sequencing of the Lassa genome showing that the virus is oldest in Nigeria and appeared only recently in Sierra Leone, and helps to explain higher fatality rates and greater disease severity in Sierra Leone. Beyond LARGE, our other top GWAS signals fall at genes involved in the immune system, including PTPRE, which modulates expression of cytokines involved in host response to viral infection, and IFRD1, involved in the activation of neutrophils in innate immune response. We also examine signals of adaptation in the Esan and Mende populations and discover numerous novel candidate loci under positive selection, providing new insights into human diversity in West Africa. This work is one of only a few surveys of genetic diversity in West Africa, a region underrepresented in GWA studies. It is also the first ever GWAS on a BL-4 agent, and demonstrates a novel genomics approach to understanding the world’s deadliest pathogens.

You may contact the first author (during and after the meeting) at tabrizi@post.harvard.edu

http://www.ashg.org/2013meeting/abstracts/fulltext/f130122559.htm

sauceny:
Only those that have been dirty for ages are immune to sickness... Eg;a mad man.

Everyone knows that yoruba people are clean people

Very clean

Lemon12:
I guess yorubas are also genetically immune to Dirtiness , cultism , cowardice , laziness , brownroof-ness ?

As if no lassa case have be reported in yoruba states .

Guy this gist touched you in unreachable places , this thing dey pain you die

Some pple are so daft! We don't cherish our researchers nor do we value our stuffs. The most annoying thing is that some pple knw nothing abt science yet they comment foolishly! As deadly as ebola was, some pple survived. There's no disease known to man that some few pple aren't resistant to. Its very possible for yoruba pple to have resistance to lassa fever, and other tribe could be resistant to other diseases. This resistance could be due to their ancestral history, their type of food or even location. Pls don't turn nairaland to a dumb place, the whole world is reading it. And if u are foolish, isn't it wise to hide ur foolishness?

The wailers are prone to 419, ritual killing, pipeline vandalization, examination malpractices, theft and evil thinking.

Decryptor:


Very laughable! First we heard that there was this yam that grows in Yorubaland that when eaten induces the birth of twins and now this!

Chineke mere ndia ebere!!

Yorubas has the highest twin conception rate in the world.

Yorubas should not be deceived by this finding and now ignore basic hygiene standards. This may be tragic at the end.

Smooyis:
Yorubas should not be deceived by this finding and now ignore basic hygiene standards. This may be tragic at the end.

Is this suppose to be funny

oodua1stson:
no. I'm not proud of what I did but some guys here just push people too far

I understand, just dont go down to their level.

lol.... I laff in spanish :Dlol.... dat kind immune.. Rat no sabi tribe ooo. Hmmmm dem neva Chichuntin.

emiye:
Yorubas has the highest twin conception rate in the world.

Who highest twin conception rate help?

emiye:
Yorubas has the highest twin conception rate in the world.

That's a fact.

Ubenedictus:
I understand, just dont go down to their level.

thanks bro

totit:




Is this suppose to be funny

Not at all. Just stating the obvious.