Breast cancer is a major and growing health issue among women.
Invasive breast cancer is the most common type cancer affecting
women worldwide, and the second-most-common type overall,
according to the Susan G. Komen foundation.

Studies show that when cannabinoids are administered and bind to endocannabinoid receptors,
they are able to inhibit cancer cell growth by preventing the proliferation of
cancer cells and by inducing cancer cell death (apoptosis).

Furthermore, cannabinoids have been found to impair both tumor angiogenesis –
the increase in localized blood flow induced by tumor cells – and
metastasis – the spreading of cancer to other organs.

CANNABINOIDS AND BREAST CANCER

There has been great medical advancements in breast cancer in recent decades,
but certain breast tumors continue to be resistant to conventional treatments.
Breast cancer is comprised of tumors that are distinct in their molecular profiles,
leading medical professionals to categorize the disease into 3 main subtypes.

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Research suggests that synthetic cannabinoids and phytocannabinoids (mainly THC and CBD)
may be useful in treating all 3 subtypes of breast cancer,
with the strongest evidence of therapeutic potential pointing to treatment of
HER2-positive and triple-negative breast tumors.

The therapeutic potential of cannabinoids is particularly important for patients
with triple-negative breast cancer, as there is no standard therapy that currently
exists and prognosis for this group of patients is poor.

In addition to their anti-cancer effects, research also shows that cannabinoids are
considerably safer and less toxic than conventional treatments.
Cannabinoids are non-toxic to non-tumor cells and are well tolerated by
patients – only eliciting relatively mild side-effects such as dizziness and fatigue.

“This compound offers the hope of a non-toxic therapy that could achieve the
same results without any of the painful side effects.” – Dr. Sean McAllister

In 2007, Dr. Sean McAllister and his team of researchers were one of the first
to discover that CBD’s cancer-fighting properties could be successfully applied to breast cancer.

As it turns out, cannabinoids can provide a variety of other benefits in the treatment of cancer,
including the prevention of nausea and vomiting associated with standard
chemotherapeutic treatments and reduction of cancer-associated pain.

Research also shows that, when combined with conventional cancer treatments,
cannabinoids are able to induce a synergistic action against cancer and tumor cells,
suggesting that the combination of conventional and cannabinoid-based treatments
may more powerful than the administration of either treatment alone.

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CLINICAL APPLICATIONS: THE CURRENT STATE

Scientific research on the effects of cannabinoids on breast cancer has been limited
to preclinical trials involving cell cultures and animal models.
Researchers believe that further preclinical trials are necessary to identify which
patient population is the most appropriate for cannabinoid treatment and which
cannabinoids specifically present the best therapeutic option for patients before
trials can advance to the clinical stage.

In a update (2013) published in the Oncology Nursing Forum, associate editor
Susan Weiss Behrend concluded:
“…cannabinoids have demonstrated anti tumor activity in preclinical breast cancer models.
Practicing oncology professionals need to be aware of the clinical potential of
these agents…” – Susan Weiss Behrend, RN

According to doctors and patients we have worked closely with, breast cancer tumors
can be effectively treated with cannabis oil. However, they caution, the ratios of the
tumor-busting cannabinoids THC and CBD must be matched to the classification
of breast cancer—with certain kinds of breast cancer, namely those that are
estrogen-positive, the tumor will actually grow if too much THC is used.

Although there are many types of breast cancer, they are usually grouped into four categories,
depending on how they show up on diagnostic tests:

Estrogen receptor positive (ER+) or progesterone receptor positive (PR+): About two in three cases of breast cancer (more in older women) have receptors for one or both of these hormones.
HER2/neu (a.k.a. HER2 or ErbB2): HER2/neu is a protein that is over-copied by certain types of breast cancer. HER2-positive cancers spread more rapidly than other types of cancer.
Triple negative: These breast cancers do not have estrogen or progesterone receptors and don’t show overproduction of HER2. Triple-negative breast cancers spread aggressively because they don’t respond to hormones or drugs that target HER2, but chemotherapy is an option.
Triple positive: These types of breast cancer are ER+ and PR+, and they have too much HER2 production. They can be treated with hormones, HER2 drugs, and chemo.

Doctor Reviewing Mammogram on X-rayResearch has shown that PR+,
HER2-positive, and triple-negative breast cancers can be effectively treated with cannabis.
The protocols recommended by doctors we work with tend to have high THC-to-CBD ratios, often around 4:1.

Cancers that involve estrogen, however, may actually spread in response to large amounts of THC.
Patients with ER+ or triple-positive breast cancer do better with lower ratios of THC to CBD—a ratio 1:1 or 1:3 is preferable, according to doctors and patients we’ve spoken with.


Do not forget to schedule your regular check-ups with your doctor.

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DammyLove

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I am committed to your healthy living and wellbeing.

DammyLove

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