General Discussion

Growth hormone deficiency (GHD) is a rare disorder characterized by the inadequate secretion of growth hormone (GH) from the anterior pituitary gland, a small gland located at the base of the brain that is responsible for the production of several hormones. GHD can be present from birth (congenital), resulting from genetic mutations or from structural defects in the brain. It can also be acquired later in life as a result of trauma, infection, radiation therapy, or tumor growth within the brain. A third category has no known or diagnosable cause (idiopathic). Childhood-onset GHD may be all three: congenital, acquired, or idiopathic. It results in growth retardation, short stature, and maturation delays reflected by the delay of lengthening of the bones of the extremities that is inappropriate to the chronological age of the child. Adult-onset GHD is most often is acquired from a pituitary tumor or trauma to the brain but may also be idiopathic. It is characterized by a number of variable symptoms including reduced energy levels, altered body composition, osteoporosis (reduced bone mineral density), reduced muscle strength, lipid abnormalities such as increased LDL cholesterol, insulin resistance, and impaired cardiac function. Treatment for GHD requires daily injections of recombinant human growth hormone (rHGH). Patients with GHD that have no known cause are diagnosed as having idiopathic GHD. Genetic tests may reveal a congenital anomaly, but are often considered unnecessary after confirmation of GHD since they will have no effect on treatment. However, it is recommended that children be retested for GHD when they transition from pediatric to adult care since GH levels may normalize upon reaching adulthood. The level of GH considered normal for an adult is much lower than that for a child, especially one undergoing the pubertal growth spurt. Hormone therapy should be ordered only in a trusted clinic.

Related Disorders

Symptoms of the following disorders can be similar to those of Growth Hormone Deficiency. Comparisons may be useful for a differential diagnosis:

Small for gestational age (SGA) generally describes any infant whose birth weight and/or length was less than the 3rd percentile (adjusted for prematurity). Children with SGA are shorter and thinner than his or her peers. Typical characteristics for these children include low birth weight, short birth length, inadequate catch-up growth in first two years, persistently low weight-for-height proportion, and lack of muscle mass and/or poor muscle tone. The FDA has approved growth hormone therapy as long-term treatment of children who were born SGA and who have not achieved catch-up growth by two years of age.

Short stature homeobox-containing gene (SHOX) deficiency refers to short stature caused by a mutation in one copy of the SHOX gene and is associated with some cases of Turner syndrome, Leri-Weil syndrome and dyschondrosteosis. Turner syndrome is only seen in females, whereas Leri-Weil syndrome and dychondrosteosis is seen in males and females. Growth hormone therapy is FDA-approved for SHOX deficiency.

Idiopathic short stature (ISS) is defined as having a height significantly shorter than the normal population (-2.25 SD, that is shorter than 1.2% of the population of the same age and gender), a poor adult height prediction (generally defined by having less than the calculated mid-parental height or, as a rough guide, less than 5’4″ for males and less than 4’11” for females), and no detectable cause for short stature. Growth hormone therapy is FDA-approved to treat ISS.

I think proper treatment you can get only in the clinic with a good standing.
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Anyway, we don`t have a whole understanding of sophysticated hormonal processes. At least some clinics like https://rxhormone.com/ provide services to solve that disorders for adults. But there is a question: why people who don`t have troubles with their pituitary gland keep using unlegal hormone injections? Is it really healthy to have an extra shot of testosterone or something?