Researchers have identified two human gene variants that could make people more susceptible to lung failure associated with COVID-19.

Tom Karlsen at Oslo University Hospital and his colleagues analysed the genomes of roughly 4,000 people from Italy and Spain: 1,980 people with COVID-19 who developed respiratory failure and more than 2,000 people who did not have the disease (D. Ellinghaus et al. Preprint at medRxiv http://doi.org/dxk7; 2020). Those with severe COVID-19 were more likely to carry either of two gene variants than people without the disease.
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One variant lies in the swathe of the genome that determines blood groups. A follow-up analysis found that people with blood type A+ had an increased risk of lung failure compared with those with other blood types, whereas those with type O blood were protected to some extent.


https://www.nature.com/articles/d41586-020-00502-w

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