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Health › Re: University Of Ibadan Discovers Cure For Sickle Cell by Abali1(m): 7:28pm On Oct 29, 2015

utytill:
But uniben teaching hospital did that to one boy last year or so?.

The bone marrow transplant as a cure for children has always been there. the difference here is that this one is for Adult Sufferers of SCD.

Health › Re: University Of Ibadan Discovers Cure For Sickle Cell by Abali1(m): 7:17pm On Oct 29, 2015

Chi59:
Great news(if true)!
There is hope!!!!

Abali1, where art thou??
Fellow warriors, there is hope!!

I am here. Am really happy about the break through. The challenge will now be getting a 'matching Donor' for the transplant.

Health › Re: University Of Ibadan Discovers Cure For Sickle Cell by Abali1(m): 7:13pm On Oct 29, 2015

jamest3:
That is a good one. Respect to all those who didn't make it before this discovery, you are our heroes according to adaptive theories. But I didn't see any mention about what happens to the genotype? Will it change from ss to aa or as?

with a successful bone marrow transplant, the patients bone marrows will then start producing Normal RBC. when this happens, the normal RBC will gradually replace all the damaged sickled RBC.
So yes, the patient will become AA, if the bone marrows used was gotten from AA person.

2 Likes

Politics › Re: Zahra Buhari Is Ambassador To Sickle Cell Aid Foundation by Abali1(m): 9:27am On Sep 21, 2015

Missonas:
A brand ambassador for Sickle cell? I think a sickle cell fighter would have been a better ambassador.Common this is not glo, mtn, knorr etc This is not an advertisement its more like an education, a very sensitive one at that!

Exactly.

Politics › Re: Zahra Buhari Is Ambassador To Sickle Cell Aid Foundation by Abali1(m): 9:01am On Sep 21, 2015

SCAF, hmmmm.
I am happy that the First family is identifying with the scourge of Sickle Cell. But I have mixed feelings about the end result.
I hope it doesn't become another Sickle Cell Foundation, like the one at Idiaraba where millions are realised in donations, but the real people who are supposed to gain from the foundation are giving just Folic Acid and some vitamins.
Kudos Nkechi Azinge and the Buhari family.

Health › Re: A Cure For Sickle Cell Anaemia. by Abali1(op): 2:46pm On Sep 18, 2015

Physicians at the University of Illinois Hospital & Health Sciences System have cured 12 adult patients of sickle cell disease using a unique procedure for stem cell transplantation from healthy, tissue-matched siblings.

Health › Re: A Cure For Sickle Cell Anaemia. by Abali1(op): 2:44pm On Sep 18, 2015

ryd3:
If this is really true the there is hope for thousands that have the condition in Africa. So many relationships have been broken also by the deadly 'are you AS' question. Thank God for the wisdom he gave these scientists.. .

I am excited about this news. Almost all the known cure for Sickle cell disease through stem cell transplant has always been for children. But with this, adult sufferers of SCD as well as children now have hope for a Cure.

Health › A Cure For Sickle Cell Anaemia. by Abali1(op): 2:31pm On Sep 18, 2015

Physicians at the University of Illinois Hospital & Health Sciences System have cured 12 adult patients of sickle cell disease using a unique procedure for stem cell transplantation from healthy, tissue-matched siblings.
The transplants were the first to be performed outside of the National Institutes of Health campus in Maryland, where the procedure was developed. Physicians there have treated 30 patients, with an 87 percent success rate. The results of the phase I/II clinical trial at UI Health, in which 92 percent of treated patients were cured, are published online in the journal
Biology of Blood & Marrow Transplantation.
The new technique eliminates the need for chemotherapy to prepare the patient to receive the transplanted cells and offers the prospect of cure for tens of thousands of adults suffering from sickle cell disease.
About 90 percent of the approximately 450 patients who have received stem cell transplants for sickle cell disease have been children. Chemotherapy has been considered too risky for adult patients, who are often more weakened than children by the disease.
"Adults with sickle cell disease are now living on average until about age 50 with blood transfusions and drugs to help with pain crises, but their quality of life can be very low," says Dr. Damiano Rondelli, chief of hematology/oncology and director of the blood and marrow transplant program at UI Health, and corresponding author on the paper.
"Now, with this chemotherapy-free transplant, we are curing adults with sickle cell disease, and we see that their quality of life improves vastly within just one month of the transplant," said Rondelli, who is also the Michael Reese Professor of Hematology in the UIC College of Medicine. "They are able to go back to school, go back to work, and can experience life without pain."
Sickle cell disease is inherited. It primarily affects people of African descent, including about one in every 500 African Americans born in the U.S. The defect causes the oxygen-carrying red blood cells to be crescent shaped, like a sickle. The misshapen cells deliver less oxygen to the body's tissues, causing severe pain and eventually stroke or organ damage.
Doctors have known for some time that bone marrow transplantation from a healthy donor can cure sickle cell disease. But few adults were transplanted because high-dose chemotherapy was needed to kill off the patients' own blood-forming cells -- and their entire immune system, to prevent rejection of the transplanted cells, leaving patients open to infection.
In the new procedure, patients receive immunosuppressive drugs just before the transplant, along with a very low dose of total body irradiation -- a treatment much less harsh and with fewer potentially serious side effects than chemotherapy.
Next, donor cells from a healthy and tissue-matched sibling are transfused into the patient. Stem cells from the donor produce healthy new blood cells in the patient, eventually in sufficient quantity to eliminate symptoms. In many cases, sickle cells can no longer be detected. Patients must continue to take immunosuppressant drugs for at least a year.
In the reported trial, the researchers transplanted 13 patients, 17 to 40 years of age, with a stem cell preparation from the blood of a tissue-matched sibling. Healthy sibling donor-candidates and patients were tested for human leukocyte antigen, a set of markers found on cells in the body. Ten of these HLA markers must match between the donor and the recipient for the transplant to have the best chance of evading rejection.
In a further advance of the NIH procedure, physicians at UI Health successfully transplanted two patients with cells from siblings who matched for HLA but had a different blood type.
In all 13 patients, the transplanted cells successfully took up residence in the marrow and produced healthy red blood cells. One patient who failed to follow the post-transplant therapy regimen reverted to the original sickle cell condition.
None of the patients experienced graft-versus-host disease, a condition where immune cells originating from the donor attack the recipient's body.
One year after transplantation, the 12 successfully transplanted patients had normal hemoglobin concentrations in their blood and better cardiopulmonary function. They reported less pain and improved health and vitality.
Four of the patients were able to stop post-transplantation immunotherapy without transplant rejection or other complications.
"Adults with sickle cell disease can be cured without chemotherapy -- the main barrier that has stood in the way for them for so long," Rondelli said. "Our data provide more support that this therapy is safe and effective and prevents patients from living shortened lives, condemned to pain and progressive complications."
www.sciencedaily.com/releases/2015/09/150916184911.htm

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Family › Re: September: Sickle Cell Awareness Month by Abali1(op): 2:28pm On Sep 18, 2015

www.sciencedaily.com/releases/2015/09/150916184911.htm
.
Physicians at the University of Illinois Hospital & Health Sciences System have cured 12 adult patients of sickle cell disease using a unique procedure for stem cell transplantation from healthy, tissue-matched siblings.
The transplants were the first to be performed outside of the National Institutes of Health campus in Maryland, where the procedure was developed. Physicians there have treated 30 patients, with an 87 percent success rate. The results of the phase I/II clinical trial at UI Health, in which 92 percent of treated patients were cured, are published online in the journal
Biology of Blood & Marrow Transplantation.
The new technique eliminates the need for chemotherapy to prepare the patient to receive the transplanted cells and offers the prospect of cure for tens of thousands of adults suffering from sickle cell disease.
About 90 percent of the approximately 450 patients who have received stem cell transplants for sickle cell disease have been children. Chemotherapy has been considered too risky for adult patients, who are often more weakened than children by the disease.
"Adults with sickle cell disease are now living on average until about age 50 with blood transfusions and drugs to help with pain crises, but their quality of life can be very low," says Dr. Damiano Rondelli, chief of hematology/oncology and director of the blood and marrow transplant program at UI Health, and corresponding author on the paper.
"Now, with this chemotherapy-free transplant, we are curing adults with sickle cell disease, and we see that their quality of life improves vastly within just one month of the transplant," said Rondelli, who is also the Michael Reese Professor of Hematology in the UIC College of Medicine. "They are able to go back to school, go back to work, and can experience life without pain."
Sickle cell disease is inherited. It primarily affects people of African descent, including about one in every 500 African Americans born in the U.S. The defect causes the oxygen-carrying red blood cells to be crescent shaped, like a sickle. The misshapen cells deliver less oxygen to the body's tissues, causing severe pain and eventually stroke or organ damage.
Doctors have known for some time that bone marrow transplantation from a healthy donor can cure sickle cell disease. But few adults were transplanted because high-dose chemotherapy was needed to kill off the patients' own blood-forming cells -- and their entire immune system, to prevent rejection of the transplanted cells, leaving patients open to infection.
In the new procedure, patients receive immunosuppressive drugs just before the transplant, along with a very low dose of total body irradiation -- a treatment much less harsh and with fewer potentially serious side effects than chemotherapy.
Next, donor cells from a healthy and tissue-matched sibling are transfused into the patient. Stem cells from the donor produce healthy new blood cells in the patient, eventually in sufficient quantity to eliminate symptoms. In many cases, sickle cells can no longer be detected. Patients must continue to take immunosuppressant drugs for at least a year.
In the reported trial, the researchers transplanted 13 patients, 17 to 40 years of age, with a stem cell preparation from the blood of a tissue-matched sibling. Healthy sibling donor-candidates and patients were tested for human leukocyte antigen, a set of markers found on cells in the body. Ten of these HLA markers must match between the donor and the recipient for the transplant to have the best chance of evading rejection.
In a further advance of the NIH procedure, physicians at UI Health successfully transplanted two patients with cells from siblings who matched for HLA but had a different blood type.
In all 13 patients, the transplanted cells successfully took up residence in the marrow and produced healthy red blood cells. One patient who failed to follow the post-transplant therapy regimen reverted to the original sickle cell condition.
None of the patients experienced graft-versus-host disease, a condition where immune cells originating from the donor attack the recipient's body.
One year after transplantation, the 12 successfully transplanted patients had normal hemoglobin concentrations in their blood and better cardiopulmonary function. They reported less pain and improved health and vitality.
Four of the patients were able to stop post-transplantation immunotherapy without transplant rejection or other complications.
"Adults with sickle cell disease can be cured without chemotherapy -- the main barrier that has stood in the way for them for so long," Rondelli said. "Our data provide more support that this therapy is safe and effective and prevents patients from living shortened lives, condemned to pain and progressive complications."

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 2:34pm On Sep 10, 2015

jnrremedy:
There are 3 major haemoglobin disorders
Sickle cell disease scd
Alpha thalesemia
Beta thalesemia
Others
Thalesemia trait is also transmitted in the same fashion as d sickle cell trait (s or c). U need to have the homozygous gene for the thalasemia trait b4 u show clinical signs of d diseases ( just like SS trait) or the S haemoglobin in presence of a gene for thal. In simple terms:
If ur genotype is AA and you have a gene of thal (ie thalesemia) you will only be a carrier(have beta thalesemia minor) but won't manifest any clinical signs (asymptomatic)
If u are AS and u have a gene of thal u will show the same clinical sings and symptoms of a sicklerr. This explains the rare case of an As and AA parents giving birth to a sickler. I believe u must have heard of such cases and d funny thing is that the electrophoresis analysis of d child will show SS. What happened here is that one of d parents is a carrier so a gene of thal was transfered to d child whose genotype happens to be AS( though genotyping of d child using electrophoresis will come our as SS ) u need a more sophisticated diagnostic tool to see d true picture
You can also directly inherit thal gene from both parents ( if both are carriers) in this case your genotype is irrelevant u will definitely show d symptoms of a sickler
Most doctors don't no or say this cos d incidence of thalasemia disease in not that high in this part of d world but that doesn't mean its not present
Am actually typing on transit so pardon my errors

WoW. This is some insight. It makes sense, but I will be grateful if you can help me with a link to read it up.
I know about Beta Thalassemia, but haven't really devoted time to studying it. Infact, I am devoting this month to the study of Beta Thalassemia.
Thank you.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 7:06am On Sep 10, 2015

maryhaam:
I can comment on this post million time,because Genotype is hurting me....its ruining me, what brought about genotype why is it hurting relationship.....why are the real ones As this are questions I need answer to.....is it just me that run into As dunnooo,its hurt

It's actually emotionally disturbing, to be searching for a compatible person and it's not even as if the genotype is written on his or her forehead. But can you compare your emotional hurt to that of birthing a baby with Sickle Cell and live in fear of not knowing whether he or she will live long enough. Even after he or she has become an adult, you still fuss over their health.
Can you compare your emotional hurt now, to when the SS child starts suffering from discrimination? Being rejected by others especially the opposite sex just because mummy and daddy didn't think it wise to find someone with a compatible genotype to marry?
If you are true to yourself, you will find someone who's compatible with you sooner than later.
goodluck.

Family › Re: September: Sickle Cell Awareness Month by Abali1(op): 6:40am On Sep 10, 2015

We have a duty to talk about Sickle Cell disease. Sometimes it's only when things must have gone that we remember to ask questions.
You can educate that neighbor, friend, church member who doesn't know much about SCD.
This month is Sickle Cell awareness Month.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 6:27am On Sep 10, 2015

jnrremedy:
Do u know its possible to still give birth to a sickling child even from an AS and AA parents. U mentioned bthal s in one of your posts.
What most people don't know (even consultant doctors ) is that genotyping for marriage purpose goes beyond d Hb variants of A,C E and S. Its medically possible to still give birth to a sickling child (having SCD crises) even from a homozygous A parent and heterozygous AS parent. This has noting to do with mutation oo

please explain how this is even possible.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 6:24am On Sep 10, 2015

OrangeDream:
She is 24
Her last major crises was rili a turbulent period.. She lost her hearing ability. Since then, she's not really been sick again that much
My fears is the uncertainty surrounding this whole thing during marriage.. I honestly do not want my kids to suffer.
Financially and emotionally, i'm
I can take decision.. But you know that, you cannot entirely rule out their participation in that your decision making process

You AA, so your kids will be fine. Yeah, sickle cell can be very challenging. But, we do live a fulfilling life and we equally love with everything we have. The decision is yours to make. Either you accept her the way she is or you let her be.
I say again, I live with sickle cell and I am married and have a kid. Sickle cell doesn't define us.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 9:07am On Sep 09, 2015

streetzdreamz:
so? Ain't ss carriers humans?oh! Diseases, death and what else again? Tell me are normal humans not prone to this two things ordinarily? You people need to stop running from death cuz it won't come, it will come knocking when you least expect it,if I end up meeting a woman that will change MA belief about marriage, and she is a carrier, we definitely walking down the aisle.

I am SS. I cannot for the life of me discriminate against my kind.
What I actually mean is that when you meet one and marriage is being discussed will you be able to stand by her and ignore dissenting voices from family and friends?
Do you know how many ladies who rejected my hand in marriage because of pressure from family and friends? Bro, it takes just more than love to really be with a warrior.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 9:02am On Sep 09, 2015

pet4ril:
don't be deceived my dear, some suffered it and never knew what it was.... I saw a couple dat has 8 children n 5 of dem happened to be sickle cells n about 4 was dead the last time I saw them remaining only one... so we should be grateful that we know what it is... please give a Bleep for dis. is 21st century

The popular ogbanje and abiku of those days, were actually SS. But because they don't know about genotype testing or compatibility they labelled it those names.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 8:52am On Sep 09, 2015

Punstar:
There has always being a lot f kids in this section ...Such an important issue yet trivial responses

Pls anyone heard abt Prenatal Genotype Diagnosis

Na God and this PGD I dey count on ooooo. #LoveComesFirst.

It cost a lot of money to do that. And if after the result comes out and the baby is SS what will you do? Abort?
Now how many prenatal diagnosis will a couple do before they get it right?
My brother, we believe that if people put emotions in check, life will be easier.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 8:48am On Sep 09, 2015

streetzdreamz:
Nice, educative thread! Not the usual ten poo to do when asking a lady out, or some bullshit about dem gaudy entertainers, my genotype n blood group is a perfect match, always wished to meet a lady with a SS genotype someday.

Be careful what you wish for. You might just get it. It takes more than I love her/him to marry a warrior.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 8:44am On Sep 09, 2015

dmcdad:
Hmmm. Nice. Thank goodness I am AA. I could help a soul out.

Yeah. You could help. At least you can equally spread the awareness of SCD. We need to help our generation and the generation next.

Family › Re: September: Sickle Cell Awareness Month by Abali1(op): 8:42am On Sep 09, 2015

This is the family section. I want members of this section to coming in here and help spread this awareness. Even if you don't have a SS or non of your family members is SS. We still need to create the awareness, we might be helping someone out there.
Suggestions
Questions
Share experiences.

1 Like

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 8:37am On Sep 09, 2015

Funjosh:
AbalI1 how are you doing, what of madam and family. Am happy to hear from you bro.

my brother, we dey. I saw this thread and decided to step in a bit. Many think Sickle cell is a joke or something to be joked with. Smh.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 8:35am On Sep 09, 2015

dmcdad:
I see... Which means the outcome could spin anywhere. How about with AA? AC + AA = ?

AC + AA
AA, AC, AC, AA
That's why AC and AS are advised to marry someone with AA. Let's help reduce the incidence of SS or SC or Sickle Beta in our generation and the generation next.
Spread the awareness.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 8:31am On Sep 09, 2015

jojomario:
is there any medical implications on the results given?
if any, state them.

SC is another variant of the sickle cell disease. While AC and AS will be okay if they were to marry AA genotype only.
SC has as much pain crisis as SS, so don't play with it.

1 Like

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 4:55am On Sep 09, 2015

euromilion:
Can I use the word,people of colour then,because I know for a fact that white people don't have sickle cell.

No. You are wrong. There are Caucasian (especially from Europe) who do have Sickle Beta Thalassemia. You can Google it.

Family › September: Sickle Cell Awareness Month by Abali1(op): 4:50am On Sep 09, 2015

Once again I lend my voice to Creating Awareness for the sickle cell disease awareness. A lot of people are of the opinion that this topic has been over flogged. But I don't think so.
This thread is here in the family section because I cringe at some of the responses I read in an earlier thread.
https://www.nairaland.com/2583479/sickle-cell-awareness-come-learn#
.
So many people out there are still very ignorant about Sickle cell disease, and it's left for us who 'wear this shoe' to keep creating awareness about this disease.
If you have questions, suggestions or news about Sickle cell, please feel free to post your comments.
Thank you.

1 Like

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 4:34am On Sep 09, 2015

euromilion:
Why does this only apply to black people?

It doesn't only apply to black people. we have people from India, Mexico, Latin Americans, etc who have Sickle Cell. But blacks are more in number.
Sickle Cell is not a racial problem.

1 Like

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 4:27am On Sep 09, 2015

dmcdad:
Wow... Whats the extent of AC in relation to AS and SS?

AC + AS will likely produce, AA, AC, AS, SC That's the probability in every pregnancy.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 4:27am On Sep 09, 2015

dmcdad:
Wow... Whats the extent of AC in relation to AS and SS?

AC + AS will likely produce, AA, AC, AS, SC That's the probability in every pregnancy.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 4:23am On Sep 09, 2015

Teempakguy:
Any SS here?

Yes sir. I equally believe OP, is SS or has someone who is.

Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 4:20am On Sep 09, 2015

OrangeDream:
I'm AA & my girl is SS.. I luv her so much but i'm scared of d future & also scared of loosing a good and beautiful gurl lyk her.. Pls,what do i do?? I have been datin her 4 1year+ now.. And marriage is in view for me.. She is d only gurl i know 4 now..
Pls, help me

I am responding to your post because of the bolded.
How old is your girl?
How often does she have crisis?
What are your fears?
Are you emotionally, and financially matured for marriage?
Can you take decisions for yourself, without bothering about what family and friends will say?
.
I am SS man, married to AA woman and I have a son. Am in my 30s and have not been hospitalized for a little over 3 years.
My wife knew about my genotype and still loved me despite it.
No one can make marriage decisions for you.

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Health › Re: Sickle Cell Awareness !! Come In And Learn..... by Abali1(m): 4:03am On Sep 09, 2015

damosade:
How about SC and AC. Update your self

SC + AC will produce
AS, SC, AC, CC
All these are probability in every pregnancy.

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