emekatheo:


Bloody errand boy and apprentice! Always envying Pharmacist. That's why you keep giving patients wrong doses of drugs.

Envy a dispenser ?? Bwahahahahah. You are deluded and should see a psychiatrist asap.

emekatheo:


Google always giving you half information. Thanks to Google but listen let me teach you for free. Paracetamol underGoes gluroronidation and sulfation to its conjugates (which I won't tell you) and these make up 95% of the excreted metabolites.
However there is an alternative pathway which makes up the remaining 5%. It is the cytochrome p450 dependent glutathion conjugation pathway. I won't tell you the name of the metabolite so you can ask Google again and learn. So what you typed up there is trash.

Have you heard of Acetylcysteine and Methionine? Mr. Doctor!!

Lol..This is ridiculous !! Acetylcysteine is cysteine analogue with a longer half life.Your methionine is just another AA that can be used for the management of paracetamol toxicity.

What is the commonest route of administration of the N-acetylcysteine in clinical settings?

And after how many seconds, minutes or hours would your antidote be useless If you fail to act ?

What zone of hepatic lobule is the commonest site of liver damage due to acetaminophen toxicity ? And why is it the commonest site ?

What type of necrosis does it cause ?

Gimme the prognostic signs of the toxicity ?

And can you tell me about the symptoms, signs and management of fulminant hepatic failure ?

The above questions are definitely beyond the scope of your curriculum.
My questions covered pharmacology, pathology and GI medicine ..

Keep calm and dispense my prescriptions quietly

.

WesleyPepper:

Lol..This is ridiculous !! Acetylcysteine is cysteine analogue with a longer half life.Your methionine is just another AA that can be used for the management of paracetamol toxicity.
What is the commonest route of administration of the N-acetylcysteine in clinical settings?

And after how many seconds, minutes or hours would your antidote be useless If you fail to act ?

And what zone of hepatic lobule is the commonest site of liver damage due to acetaminophen toxicity ?

What type of necrosis does it cause ?

Gimme the prognostic signs of the toxicity ?

And can you tell me about the symptoms, signs and management of fulminant hepatic failure ?

The above questions are definitely beyond the scope of your curriculum.
My questions covered pharmacology, pathology and GI medicine ..

Keep calm and dispense my prescriptions quietly

You finally finished the guy. Next time, he will learn to mind his dispensing job as a pharmacist

WesleyPepper:

Lol..This is ridiculous !! Acetylcysteine is cysteine analogue with a longer half life.Your methionine is just another AA that can be used for the management of paracetamol toxicity.

What is the commonest route of administration of the N-acetylcysteine in clinical settings?

And after how many seconds, minutes or hours would your antidote be useless If you fail to act ?

What zone of hepatic lobule is the commonest site of liver damage due to acetaminophen toxicity ? And why is it the commonest site ?

What type of necrosis does it cause ?

Gimme the prognostic signs of the toxicity ?

And can you tell me about the symptoms, signs and management of fulminant hepatic failure ?

The above questions are definitely beyond the scope of your curriculum.
My questions covered pharmacology, pathology and GI medicine ..

Keep calm and dispense my prescriptions quietly

pls stop here brother, lol, haaaaaa

u wan kill that pharmD guy ni,, pls let's save his pharmD ego ,this is a public forum, let's pity his certificate..

though I know amarabae will know this one sha, she knows more and use to correct doctor.. lol.

OH I forgot, she will tell us it will be too childish to answer this here..

work out of thread jeje

WesleyPepper:

Lol..This is ridiculous !! Acetylcysteine is cysteine analogue with a longer half life.Your methionine is just another AA that can be used for the management of paracetamol toxicity.

What is the commonest route of administration of the N-acetylcysteine in clinical settings?

And after how many seconds, minutes or hours would your antidote be useless If you fail to act

What zone of hepatic lobule is the commonest site of liver damage due to acetaminophen toxicity ? And why is it the commonest site ?

What type of necrosis does it cause ?

Gimme the prognostic signs of the toxicity ?

And can you tell me about the symptoms, signs and management of fulminant hepatic failure ?

The above questions are definitely beyond the scope of your curriculum.
My questions covered pharmacology, pathology and GI medicine ..

Keep calm and dispense my prescriptions quietly

Abegi pity the doctor wannabe. Thanks for putting the academic dwarf in his right place. You just confirmed to me the awesomeness of mbbs program. I am humbled to be a doctor. I wish we are in ward round so that stuff will just flow unhindered. Thanks once again

theuniqueone:

Abegi pity the doctor wannabe. Thanks for putting the academic dwarf in his right place. You just confirmed to me the awesomeness of mbbs program. I am humbled to be a doctor. I wish we are in ward round so that stuff will just flow unhindered. Thanks once again

I dey loyal boss...
We need to keep them in check lest they mislead the ignorant public.

danilmo:


pls stop here brother, lol, haaaaaa

u wan kill that pharmD guy ni,, pls let's save his pharmD ego ,this is a public forum, let's pity his certificate..

though I know amarabae will know this one sha, she knows more and use to correct doctor.. lol.

OH I forgot, she will tell us it will be too childish to answer this here..

work out of thread jeje

Lmao

WesleyPepper:

Lol..This is ridiculous !! Acetylcysteine is cysteine analogue with a longer half life.Your methionine is just another AA that can be used for the management of paracetamol toxicity.

What is the commonest route of administration of the N-acetylcysteine in clinical settings?

And after how many seconds, minutes or hours would your antidote be useless If you fail to act ?

What zone of hepatic lobule is the commonest site of liver damage due to acetaminophen toxicity ? And why is it the commonest site ?

What type of necrosis does it cause ?

Gimme the prognostic signs of the toxicity ?

And can you tell me about the symptoms, signs and management of fulminant hepatic failure ?

The above questions are definitely beyond the scope of your curriculum.
My questions covered pharmacology, pathology and GI medicine ..

Keep calm and dispense my prescriptions quietly

You want to kill the guy? someone who have no idea what histology is not to talk of Morbid Anatomy?
That's absolutely beyond his scope.

[quote author=emekatheo post=67678181]

Answer it 'PROFESSOR KNOW ALL'. Quack doctor. It's still basic pharmacology question of common paracetamol you prescribe everyday. Which medical school did you finish from please? I pity patients that come to see you. Which hospital do you even work in?[/quote
But bro how does the mechanisms for elimination of 1g pcm help to save patients lives? no wonder pharmacists are limited to dispensing drugs and aba boys do better in drug biz.

emekatheo:


Google always giving you half information. Thanks to Google but listen let me teach you for free. Paracetamol underGoes gluroronidation and sulfation to its conjugates (which I won't tell you) and these make up 95% of the excreted metabolites.
However there is an alternative pathway which makes up the remaining 5%. It is the cytochrome p450 dependent glutathion conjugation pathway. I won't tell you the name of the metabolite so you can ask Google again and learn. So what you typed up there is trash.

Have you heard of Acetylcysteine and Methionine? Mr. Doctor!!

Nice one mr. But how does this help a patient. Btw we know more than this. my pharmacology lecturers admitted medical students perform better than pharmacy students in pharmacology.

WesleyPepper:

Lol..This is ridiculous !! Acetylcysteine is cysteine analogue with a longer half life.Your methionine is just another AA that can be used for the management of paracetamol toxicity.

What is the commonest route of administration of the N-acetylcysteine in clinical settings?

And after how many seconds, minutes or hours would your antidote be useless If you fail to act ?

What zone of hepatic lobule is the commonest site of liver damage due to acetaminophen toxicity ? And why is it the commonest site ?

What type of necrosis does it cause ?

Gimme the prognostic signs of the toxicity ?

And can you tell me about the symptoms, signs and management of fulminant hepatic failure ?

The above questions are definitely beyond the scope of your curriculum.
My questions covered pharmacology, pathology and GI medicine ..

Keep calm and dispense my prescriptions quietly

ideally i shouldn't have given a response to this but just to put everything in the right perspective i it's needful to give you an answer although I'm surprised that you're being taught this at postgraduate level in medical sciences since you're a resident dr.
I will answer your questions one after the other.
1. The commonest route of administration of NAC is the intravenous route because onset of action is fastest through this route. IV route is also preferred because patients with PCM toxicity are always unconscious. If there is some levels of consciousness activated charcoal should be administered too.
2. The usual time to act after pcm toxicity is between 8 to 10 hrs but even at that anytime such a patient present to the hospital he should still be given NAC so late presentation should never preclude it's administration.
3. The site of the liver mostly damaged is the centre lobular because its a highly perfused part. The metabolic enzymes for pcm metabolism are are also found in high concentration there too so the most affected part.
4. Type of necrosis is fulminating hepatic necrosis.
5. signs of toxicity usually occur in four phases. If you are a good you should know.
6. Those signs are majorly encephalopathy, cerebral edema, raised intracranial pressure and of course jaundice.
I can't answer all your questions now...i just got back from work. I'm hungry but shocked that this what you're being taught in your so called post graduate studies...If you meet with a postgraduate clinical pharmacist you'll be ashamed of yourself.
Next time ask questions that are evidence base not this academic one.
No matter how you try to present yourself from research to health care the pxcist is your Lord

WesleyPepper:
I dey loyal boss... We need to keep them in check lest they mislead the ignorant public.

To keep who in check? Your ignorance i guess

bornolowu:
313,000 naira.... thunder fire JOHESU executive for this kind of disinformation

If you don't keep shut I will paste payslips and tables used to prepare Salaries, you m0ron

jefdr001:

Nice one mr. But how does this help a patient. Btw we know more than this. my pharmacology lecturers admitted medical students perform better than pharmacy students in pharmacology.

You probably went to a school that doesn't offer pharmacy as a course so your pharmacology lecture is probably a pharmacologist so we understand...there's equally rivalry between us...Some even claim they have a better knowledge of pharmacy more than us so we understand.

DABMarkNig2019:

You probably went to a school that doesn't offer pharmacy as a course so your pharmacology lecture is probably a pharmacologist so we understand...there's equally rivalry between us...Some even claim they have a better knowledge of pharmacy more than us so we understand.

Lol. My pharmacy school is probably older than urs. and we don't have pharmacologists as lecturers. Just very few doctors and pharmacists. Profs

jefdr001:

Lol. My pharmacy school is probably older than urs. and we don't have pharmacologists as lecturers. Just very few doctors and pharmacists.

it's okay...I've given up so you're the winner since you're all knowing. don't quote me again oga bikonu.
congratulations.

Kindly paste. Thank you. I know you will never find one to paste

Fearcom:



If you don't keep shut I will paste payslips and tables used to prepare Salaries, you m0ron

Mires:


Odiegwu! "No fresh Doctor take (sic) home 300k".

How much is a house officer entitled to monthly in public service let alone a junior registrar?

Nigerians and their selfishness. They will be quick to say it is a lie but won't say it out because they know that they are not fighting a just course.

When I start pasting their payslips and salary table they will keep quiet.

DABMarkNig2019:

it's okay...I've given up so you're the winner since you're all knowing. don't quote me again oga bikonu.
congratulations.

I can see you are happy to see me mention pharmacists. I mean senior pharmacists{profs}. They beefed us even as teachers but lippincot and katzung are so small.

Paste sef, let there be rest. Your claim is false

Fearcom:


When I start pasting their payslips and salary table they will keep quiet.

DABMarkNig2019:

ideally i shouldn't have given a response to this but just to put everything in the right perspective i it's needful to give you an answer although I'm surprised that you're being taught this at postgraduate level in medical sciences since you're a resident dr.
I will answer your questions one after the other.
1. The commonest route of administration of NAC is the intravenous route because onset of action is fastest through this route. IV route is also preferred because patients with PCM toxicity are always unconscious. If there is some levels of consciousness activated charcoal should be administered too.
2. The usual time to act after pcm toxicity is between 8 to 10 hrs but even at that anytime such a patient present to the hospital he should still be given NAC so late presentation should never preclude it's administration.
3. The site of the liver mostly damaged is the centre lobular because its a highly perfused part. The metabolic enzymes for pcm metabolism are are also found in high concentration there too so the most affected part.
4. Type of necrosis is fulminating hepatic necrosis.
5. signs of toxicity usually occur in four phases. If you are a good you should know.
6. Those signs are majorly encephalopathy, cerebral edema, raised intracranial pressure and of course jaundice.
I can't answer all your questions now...i just got back from work. I'm hungry but shocked that this what you're being taught in your so called post graduate studies...If you meet with a postgraduate clinical pharmacist you'll be ashamed of yourself.
Next time ask questions that are evidence base not this academic one.
No matter how you try to present yourself from research to health care the pxcist is your Lord

Those doctors are always scare of pharmacist that's why they tremble and poo on their pants whenever they hear pharmacists are comin for ward round and run to report to their CMAC.
See the kind of question a resident doctor is askin that a 3rd year student in pharmacy school will comfortably answer. Remind those errand boys and apprentice too that there will be high levels of aminotranserase, hypoprothrombinemia and renal failure can also occur.
Those quacks should relax and learn from pharmacists once it comes to drugs and medications.
It took the combine efforts of more than 5 so called doctors and up to 24hours to respond to 2nd year basic pharmacology question I asked which they cannot answer, rather they twist the question and asked what a 3rd year pharmacy student will answer. Shame on these doctors. If you want to avoid these quacks killing you with drugs, always ask your pharmacist.
Doctors always envying pharmacist.
If you are not a pharmacist, hide your face.

WesleyPepper:

Lol..This is ridiculous !! Acetylcysteine is cysteine analogue with a longer half life.Your methionine is just another AA that can be used for the management of paracetamol toxicity.

What is the commonest route of administration of the N-acetylcysteine in clinical settings?

And after how many seconds, minutes or hours would your antidote be useless If you fail to act ?

What zone of hepatic lobule is the commonest site of liver damage due to acetaminophen toxicity ? And why is it the commonest site ?

What type of necrosis does it cause ?

Gimme the prognostic signs of the toxicity ?

And can you tell me about the symptoms, signs and management of fulminant hepatic failure ?

The above questions are definitely beyond the scope of your curriculum.
My questions covered pharmacology, pathology and GI medicine ..

Keep calm and dispense my prescriptions quietly

Olodo answer my question and tell us how the hepatotoxicity occurs and stop peeing on your pant when a pharmacist is talkin. I already mentioned some of the answers to your fellow quack. It took you up to 24hours with the help of Google and your dumb colleagues to respond to a simple question on a simple and so common drug as paracetamol. Doctor! Doctor!! Relax and learn from a pharmacist, you errand boy and apprentice. Keep doing copy and paste of you consultant work from page to page and from folder to folder.

If you are not a pharmacist, hide your face.

jefdr001:

Nice one mr. But how does this help a patient. Btw we know more than this. my pharmacology lecturers admitted medical students perform better than pharmacy students in pharmacology.

When I see an undergraduate I know. What level are you in bro?

emekatheo:


Olodo answer my question and tell us how the hepatotoxicity occurs and stop peeing on your pant when a pharmacist is talkin. I already mentioned some of the answers to your fellow quack. It took you up to 24hours with the help of Google and your dumb colleagues to respond to a simple question on a simple and so common drug as paracetamol. Doctor! Doctor!! Relax and learn from a pharmacist, you errand boy and apprentice. Keep doing copy and paste of you consultant work from page to page and from folder to folder.

If you are not a pharmacist, hide your face.

So with all this knowledge You guys couldn't attend to your fellow johesu members that had accident but leave them to the mercy of quacks?
I know many pharmacists that prosper only by selling codeine and tramadol.
If you guys are that knowledgeable why do pharmacists go back to study mbbs?
Your knowledge can not match that of a medical doctor. You just know drugs but u have very shallow knowledge on its clinical applications.
You will be surprised how shallow ur knowledge is in the presence of a medical doctor.
You think a doctor's knowledge of pharmacology only ends with p/kinetic,p/dynamic,moa n sideeffects?
let me give u 3 take home clinical problem to ponder on

1) why wouldn't you like to give hematinics to a child with mild to moderate anemia with an acute febrile illness?

2) why wouldn't you like to start a px with previous thrombotic event on warfarin alone?

3)why wouldn't you like to give paracetamol to a child with fever untill u rule out a viral infection?

Let's see how you can use ur knowledge in real clinical setting.....

theuniqueone:

Abegi pity the doctor wannabe. Thanks for putting the academic dwarf in his right place. You just confirmed to me the awesomeness of mbbs program. I am humbled to be a doctor. I wish we are in ward round so that stuff will just flow unhindered. Thanks once again

Wailer!
I pity you and also pity those that come to see you. Let God save them from your hands. Shame on you. You are hiding under the shadow of your colleague that can't even aswer simple question. That's why you keep doing copy and paste in the clinic and keep killin innocent patients with your illiteracy. You wouldn't want pharmacist to take up ward round because you are scared. We will keep exposing you quacks till you humble youself and learn. Pharmacists will keep exposing you. Simple paracetamol question you cannot answer and you call youself a doctor. Which school did you graduate from?

emekatheo:


Wailer!
I pity you and also pity those that come to see you. Let God save them from your hands. Shame on you. You are hiding under thn't even aswer simple question. That's why you keep doing copy and paste in the clinic and keep killin innocent patients with your illiteracy. You wouldn't want pharmacist to take up ward round because you are scared. We will keep exposing you quacks till you humble youself and learn. Pharmacists will keep exposing you. Simple paracetamol question you cannot answer and you call youself a doctor. Which school did you graduate from?

mr.paracetamol. why wouldn't u like to give paracetamol to a febrile child untill you rule out viral infection?

I don't ask cram work or googleable nonsense but real life issues....

TempoJames:


So with all this knowledge You guys couldn't attend to your fellow johesu members that had accident but leave them to the mercy of quacks?
I know many pharmacists that prosper only by selling codeine and tramadol.
If you guys are that knowledgeable why do pharmacists go back to study mbbs?
Your knowledge can not match that of a medical doctor. You just know drugs but u have very shallow knowledge on its clinical applications.
You will be surprised how shallow ur knowledge is in the presence of a medical doctor.
You think a doctor's knowledge of pharmacology only ends with p/kinetic,p/dynamic,moa n sideeffects?
let me give u 3 take home clinical problem to ponder on

1) why wouldn't you like to give hematinics to a child with mild to moderate anemia with an acute febrile illness?

2) why wouldn't you like to start a px with previous thrombotic event on warfarin alone?

3)why wouldn't you like to give paracetamol to a child with fever untill u rule out a viral infection?

Let's see how you can use ur knowledge in real clinical setting.....

1. Why wouldn't you give hematinics to a child with acute febrile illness that is placed on artemisua anua derivative?

2. Why wouldn't you like to start a patient with previous thrombotic event on low dose acetylsalycilic acid or clopidogrel alone?

3. Why wouldn't you like to give antibiotics to a child with flu.

Good luck.

emekatheo:


1. Why wouldn't you give hematinics to a child with acute febrile illness that is placed on artemisua anua derivative?

2. Why wouldn't you like to start a patient with previous thrombotic event on low dose acetylsalycilic acid or clopidogrel alone?

3. Why wouldn't you like to give antibiotics to a child with flu.

Good luck.

You haven't answered my questions. I think you are afraid to expose your incompetence.

Were u ever taught that in the first 3 days of administration that warfarin has thrombotic tendency and should be given along with another anticoagulant like I.v heparin for the first 3 days? No ...u just cram nonsense.

Look at you ...what a show of complete nonentity.

In the first place r all acute febrile illness malaria? Stupidity! That is how a pharmacist tx a 12yr old girl with menigitis as resistant malaria untill the girl came down with cranial nerve 8 palsy(sensorineural deafness).





You think I framed up those questions? Those are typically what a doctor is faced with. Not just drug-drug interactions. How many px have died by combining ciprofloxacin with paracetamol? But dare give digoxin to a px with heart failure secondary ishemic hrt dx the patient is as good as dead.
I don't expect a good clinical acumen from a pharamacist afterall you guys know nothing about pathology. You think microbiology is pathology?
Have you ever been to a morbid pathology, chemical pathology or hematology class?
Only a doc with good knowledge of hematology can answer my first question.
only a doc with good knowledge of morbid pathology can answer my third ?
Unlike a pharmacist, a medical doc's knowledge pf pharmacology doesn't end with just drug use,moakinetics n dynamics n indications/c-indications n sideeffects.....a doc studies step by step how a drug can modify, alleviate or even worsen a pathology.
A pharmacist can't make a diagnosis...ofcourse a pharmacist knows nothing abt pathology.



I have just teach you the answer to my no.2 question now answer no1 and 3 and prove to me you are not a total duns.

I don laugh sotey, tears comot for my eyes..

Dr tempojames, easy with that pharmD guy naw..

before he ll vexx to take the next jamb form and fill for medicine, that if he can still pass jamb, a jamb duller always a jamb duller,
biko kuku settle for ur pharm @emekatheo.. no reason am

lmao.. am sure the guy would av searched google and got dissapointed, even his pharm lecturer too will b helpless ,

though am sure amarabae will know more than this,
that pharmD na wash,
hian something ordinary amarabae can answer and also correct self !!

emekatheo:


Olodo answer my question and tell us how the hepatotoxicity occurs and stop peeing on your pant when a pharmacist is talkin. I already mentioned some of the answers to your fellow quack. It took you up to 24hours with the help of Google and your dumb colleagues to respond to a simple question on a simple and so common drug as paracetamol. Doctor! Doctor!! Relax and learn from a pharmacist, you errand boy and apprentice. Keep doing copy and paste of you consultant work from page to page and from folder to folder.

If you are not a pharmacist, hide your face.

Lmao.. The anonymity of the internet provides everyone the opportunity to say thrash and get away with it.

There's nothing to learn from you intellectually inadequate dispensers.
I'd rather learn from an experienced matron .

You folks are just one of the many things wrong with the country. You want to lay claim to what you are not. Smh

Bloody dispenser with a single digit IQ

DABMarkNig2019:

ideally i shouldn't have given a response to this but just to put everything in the right perspective i it's needful to give you an answer although I'm surprised that you're being taught this at postgraduate level in medical sciences since you're a resident dr.
I will answer your questions one after the other.
1. The commonest route of administration of NAC is the intravenous route because onset of action is fastest through this route. IV route is also preferred because patients with PCM toxicity are always unconscious. If there is some levels of consciousness activated charcoal should be administered too.
2. The usual time to act after pcm toxicity is between 8 to 10 hrs but even at that anytime such a patient present to the hospital he should still be given NAC so late presentation should never preclude it's administration.
3. The site of the liver mostly damaged is the centre lobular because its a highly perfused part. The metabolic enzymes for pcm metabolism are are also found in high concentration there too so the most affected part.
4. Type of necrosis is fulminating hepatic necrosis.
5. signs of toxicity usually occur in four phases. If you are a good you should know.
6. Those signs are majorly encephalopathy, cerebral edema, raised intracranial pressure and of course jaundice.
I can't answer all your questions now...i just got back from work. I'm hungry but shocked that this what you're being taught in your so called post graduate studies...If you meet with a postgraduate clinical pharmacist you'll be ashamed of yourself.
Next time ask questions that are evidence base not this academic one.
No matter how you try to present yourself from research to health care the pxcist is your Lord

This mumu go copy google.
Wannabe doctor.. my last question gave him away.

Clowns who can't even lace the shoes of a pre clinical medical students