All Medical and Health professionals are invited to come in and drop ideas as we brainstorm on tackling this deadly filovirus.


*No unneccesary Jokes pls. Only intelligent comments from Professionals and concerned contributors*



Mods pls do the needful. We have a National emergency on our hands! Thank you..

Okay,nice idea @Op

Seconding,no joke pleas.

Good idea @Op

Wish i could be of help.

I'm very interested in the development of Vaccine and treatment of Ebola.


Garcinia kola also known as bitter Kola has shown some promise. Experts in pharmacognosy can shed more light on this.

Survivors of Ebola are confered permanent immunity. Scientists, Serologists and Immunologists can shed more light on how this happens.

Can an assymptomatic patient transmit
the virus during incubation period?...Epidemiologists should tell us what they think.

Can the Serum of a survivor really help in the treatment of infected patient?...if true..how does this happens?

What other Strains of Ebola do we have and which is more Virulent?

The general principle of most vaccination is the administration of attenuated doses of the DISEASE-CAUSING organism (e.g Ebola) to elicit antibody-antigen reaction and produce Memory T-cells which will help the body 'remember' not to get infected next time the organism tries to invade the body..

How does this help in the Ebola issue?. How do we attenuate the Ebola virus?
Can we identify the part of the virus that causes virulence and mortality in humans and then 'delete' before introduction as vaccines.

Pls drop any idea you've got..this is a brainstorming session.

Pls who are the Mods in the Health Section?

Haba..Catapult this thread to the front page. Intelligent ideas are locked up somewhere in people's brain, an effort is made to gather them, but you remain apathetic?

Do you really understand the gravity of what we have at hand?

Front page pls. God has given us the power to conquer the world including Ebola. Let the experts brainstorm.

dozzybaba: The general principle of most vaccination is the administration of attenuated doses of the DISEASE-CAUSING organism (e.g Ebola) to elicit antibody-antigen reaction and produce Memory T-cells which will help the body 'remember' not to get infected next time the organism invades the body..

How does this help in the Ebola issue?. How do we attenuate the Ebola virus?
Can we identify the part of the virus that causes virulence and mortality in humans and then 'delete' before introduction as vaccines.

Antibodies may look promising....as in the serum produced.

As the following article says...

Antibody titers against Ebola virus GPs are readily detectable in patients who recover from Ebola virus infection; however, anecdotal reports have indicated that serum from recovered patients did not consistently protect against infection or exhibit neutralization of virus replication in cell culture. Furthermore, passive transfer of antibodies in animal models only delays the onset of symptoms and does not alter overall survival . More recently, the neutralization of virus replication by selected monoclonal antibodies isolated from the bone marrow of recovered patients was demonstrated in vitro and monoclonal antibodies that recognize specific epitopes of Ebola virus GP have been shown to confer immune protection in a murine model of Ebola virus infection (15, 45) and in guinea pigs (25). However, it is relatively easy to protect against infection in the mouse model, and protection of guinea pigs required a high dose of antibody administered very close to the time of virus challenge. Taken together, these results suggest that antibodies alone do not provide protective immunity in a natural context and that cellular immunity is likely to play a significant role in virus clearance. Whether hyperimmune serum from surviving vaccinated animals or certain infrequently occurring antibodies are capable of attenuating infection remains unknown, but such antibodies could potentially contribute to therapy if they can be identified and optimized.

In other words...the serum method might work....but it remains to be seen.

The article quoted also appears to suggest(based on a study done in Gabon) that a initial immune response that is T-cell based is crucial to surviving Ebola.

Survivors exhibited more significant IgM responses, clearance of viral antigen, and sustained T-cell cytokine responses, as indicated by high levels of T-cell-related mRNA in the peripheral blood. In contrast, antibodies specific for the virus were nearly undetectable in fatal cases, and while gamma interferon (IFN-γ) was detected early after infection, T-cell cytokine RNA levels were more indicative of a failure to develop adaptive immunity in the days preceding death.

More at Ebola Virus Pathogenesis: Implications for Vaccines and Therapies by Nancy Sullivan, Zhi-Yong Yang, and Gary J. Nabel*

See also the abstract of the Gabon Study

Hmmmmmm

bushdoc9919:

Antibodies may look promising....as in the serum produced.

As the following article says...



In other words...the serum method might work....but it remains to be seen.

The article quoted also appears to suggest(based on a study done in Gabon) that a initial immune response that is T-cell based is crucial to surviving Ebola.



More at Ebola Virus Pathogenesis: Implications for Vaccines and Therapies by Nancy Sullivan, Zhi-Yong Yang, and Gary J. Nabel*

See also the abstract of the Gabon Study

Thank you very much for submission i followed your links they were intellectually juicy. Something caught my interest on the Gabon study link -the immunologic responses of survivors in contrast to ebola fatality cases.

In survivors, early and increasing levels of IgG, directed mainly against the nucleoprotein and the 40-kDa viral protein, were followed by clearance of circulating viral antigen and activation of cytotoxic T cells, which was indicated by the upregulation of FasL, perforin, CD28 and gamma interferon mRNA in peripheral blood mononuclear cells. In contrast, fatal infection was characterized by impaired humoral responses, with absent specific IgG and barely detectable IgM.

source--http://www.nature.com/nm/journal/v5/n4/full/nm0499_423.html

From above increasing levels of IgG seems to be key for survival, we also know about Intravenous Immunoglobulin.

This question begs-Can IgG be transfused in this case as the patient's immune system battles to mop up the invasion of the virus?

We may just try it out on a patient in controlled high-level biosafety milieus. But timing will be key as "events very early in Ebola virus infection determine the control of viral replication and recovery or catastrophic illness and death", if i may quote the same source.

God, guide us and protect us from all evils, Amen.

Another failed thread by Nairaland's most famous quack medical assistant.

This purpose of this thread is admirable but it is far beyond your very limited medical knowledge.
You are not in a position to make any professional contribution on the thread you have created apart from mundane opinion.

This could form a very intelligent discourse but we need fully qualified Medical Doctors to provide scientific and professional opinions and not sub standard wannabes who do not even know the basics of the periodic table.

Anambra Adigo Mma

Seems nobody knows anything about ebola.

Perhaps we should invite any interested westerners to the thread.

odinma1: Another failed thread by Nairaland's most famous quack medical assistant.

This purpose of this thread is admirable but it is far beyond your very limited medical knowledge.
You are not in a position to make any professional contribution on the thread you have created apart from mundane opinion.

This could form a very intelligent discourse but we need fully qualified Medical Doctors to provide scientific and professional opinions and not sub standard wannabes who do not even know the basics of the periodic table.

Anambra Adigo Mma

Italiano1 the waste of space...so you came here to vomit rotten amala on my Scientific brainstorming thread....

Italiano1 aka I-lived-in-Ireland-for-6-years (who takes pictures of gala hawkers all the way from ojota to dopemu bridge as he takes a free lift home towards Iyana-ipaja in a rickety wine-coloured scrap metal ) has no idea how Scientific solutions are provided to research problems...Exactly how they expose themselves thinking they are fighting dozzybaba. I'll bet you he thinks Louis pasteur was a medic.

Even our Physicians,Scientists will laugh at your glorification of idiocy..

Oga you are intellectually beneath me, of course you've once confessed to that...
Let me give you an expo, My final research was published in two Biomedical journals- PubMEd and PAMJ. Go find me there if you are intelligent enough to get my real names(something you've been trying to do for 3 years proving that you are a fake IT specialist)...

My little contribution to Science is a feat your 100th generation may never achieve if you transfer the gene that codes for your inadequate cerebral capacity to them..

I hereby ask the security men to kick out this m.a.dm.an from this hall. So Intellectuals can brainstorm in serenity..

Back to topic...

I read on Yahoo news that one of the American medics Dr. Kent, asked for transfusion of blood from the a little boy he treated. That seem to substantiate the claim that IgG antibodies specifically raised from antibody-antigen reaction during ebola invasion could be helpful in the treated of new Ebola cases as i previously opined.

Prof Iwu a Virologist also talked about the invitro anti-ebola actions of Garcinia Kola, but admitted that the chemical structure maybe altered to give sustainable results invivo. Structural and pharmaceutical Chemists should shed more light on this...

What is Ebola please? No jokes, is it a bacteria or pathogen?

dozzybaba:

[s]Italiano1 the waste of space...so you came here to vomit rotten amala on my Scientific brainstorming thread....

Italiano1 aka I-lived-in-Ireland-for-6-years (who takes pictures of gala hawkers all the way from ojota to dopemu bridge as he takes a free lift home towards Iyana-ipaja in a rickety wine-coloured scrap metal ) has no idea how Scientific solutions are provided to research problems...Exactly how they expose themselves thinking they are fighting dozzybaba. I'll bet you he thinks Louis pasteur was a medic.

Even our Physicians,Scientists will laugh at your glorification of idiocy..

Oga you are intellectually beneath me, of course you've once confessed to that...
Let me give you an expo, My final research was published in two Biomedical journals- PubMEd and PAMJ. Go find me there if you are intelligent enough to get my real names(something you've been trying to do for 3 years proving that you are a fake IT specialist)...

My little contribution to Science is a feat your 100th generation may never achieve if you transfer the gene that codes for your inadequate cerebral capacity to them..

I hereby ask the security men to kick out this m.a.dm.an from this hall. So Intellectuals can brainstorm in serenity.. [/s]

I got you where I wanted. Mechie Onu Gi there, you Onye Nzuzu

I have no idea what you are talking about -you failed medical student. All your postulations are a figment of your rabid imagination and as usual you are way off the mark, it is not your fault bros. You are wired to be a low achiever in life. You have no clue and that makes me happy.

You started a thread a week ago and you have being ignored by all intelligent medical practitioners on NL So far, you have made 75% of the posts on your sub-standard thread-Still on 1 page after a week. That should tell you that no one cares about your opinion, because at the end of the day you are not a Medical Doctor so you have no right to posit on the topic you started. You are a medical assistant aka glorified nurse who wasted his parents money to complete a course that is basically worthless. Your destiny is to listen attentively to Medical practitioners and carry out their instructions. All these Johesu fight up and down will not change reality. However, it is not too late, you can go and start a Medical degree at your age but you and I know the outcome

Please save your BS about writing published papers for the dogs and the illiterates in your village Common dude like seriously? Are you insane? You can not even write coherently on NL not to talk of being published by an academically peer reviewed journal-Are these journals based in Aba or Onitsha? Who dafuq do you think you are deceiving Nwanne? So basically, you had this wonderful last year project accepted and published in Scientific journals and you ended up being a Fake Chemist selling unadulterated drugs to earn a miserable living? Tell us another lie Dozzybaba.

Your intellectual prowess has not improved your living conditions to the extent that you still have to make a public appeal to get basic amenities? You must be so high on your own Bull.shi.t to think you are making any sense Dozzy. Like most of my Igbo brothers on NL, you are just a noisemaker. No substance as usual

By the way....

Anambra Adigo Mma

Not going to post much. . . You guys should read the thread in the link provided in my second post carefully. A lot of Vital info that can be helpful. Op did a good job researching.

Sorry android phone won't pastw after copy hence the link being in another post.

Interested

odinma1:



[s]I got you where I wanted. Mechie Onu Gi there, you Onye Nzuzu

I have no idea what you are talking about -you failed medical student. All your postulations are a figment of your rabid imagination and as usual you are way off the mark, it is not your fault bros. You are wired to be a low achiever in life. You have no clue and that makes me happy.

You started a thread a week ago and you have being ignored by all intelligent medical practitioners on NL So far, you have made 75% of the posts on your sub-standard thread-Still on 1 page after a week. That should tell you that no one cares about your opinion, because at the end of the day you are not a Medical Doctor so you have no right to posit on the topic you started. You are a medical assistant aka glorified nurse who wasted his parents money to complete a course that is basically worthless. Your destiny is to listen attentively to Medical practitioners and carry out their instructions. All these Johesu fight up and down will not change reality. However, it is not too late, you can go and start a Medical degree at your age but you and I know the outcome

Please save your BS about writing published papers for the dogs and the illiterates in your village Common dude like seriously? Are you insane? You can not even write coherently on NL not to talk of being published by an academically peer reviewed journal-Are these journals based in Aba or Onitsha? Who dafuq do you think you are deceiving Nwanne? So basically, you had this wonderful last year project accepted and published in Scientific journals and you ended up being a Fake Chemist selling unadulterated drugs to earn a miserable living? Tell us another lie Dozzybaba.

Your intellectual prowess has not improved your living conditions to the extent that you still have to make a public appeal to get basic amenities? You must be so high on your own Bull.shi.t to think you are making any sense Dozzy. Like most of my Igbo brothers on NL, you are just a noisemaker. No substance as usual

By the way....

Anambra Adigo Mma [/s]

. All these epistles for me?..About 350 words in all.
After having you thrown out by the security men you barked out about 350 incoherent words at Dozzy. Count them. Dozzy must have hit you in the groin. Now who's the boss here.
Italiano1..Let me reveal the aetiology of your pains to the whole world. Your bitterness against me started in 2013, when i gave you and your goons a thorough beating on that fashola thread, you 'rebranded" yourself and came with this fake identity..... . I humbly remain your boss. https://www.nairaland.com/1455268/fashola-apologises-misunderstanding-igbo-relocation/16#18435089

You claimed you live in Ireland but were caught taking taunting pictures of gala sellers. Why did you hurriedly remove some of the pictures you took from that rotten car that gave you a lift to dopemu from "your ireland". One reason, it depicted your lowlife status. You shot yourself in the foot https://www.nairaland.com/1479768/deportees-slam-n1bn-suit-against/9#18856337
Cybercafe attendant that claims he is an "IT specialist"..IT fire!..bwhahahaha
I don't wanna sound proud but Italiano1 leave all these running around and stalking Dozzybaba. He is head and shoulder above you financially and intellectually, ONE BIG TRUTH YOU KNOW THAT REALLY HURTS. In fact in my line of enterprise, we don't advertize, it is unethical, but what i make in week, you WILL never make in a month in your salaried job in that cybercafe..my brother. Quote me.
I'm not a key member of JOHESU, i serve myself in the private sector and i'm not a hungry hitchhiker as we saw in the "gala" pictures you took from that passenger's seat in that rotten "motor".
Send us your office number.. I may convince your Anambra boss to give you a raise. So you can lose some of this bitterness against your eternal lords.

*Walks back into the Conference hall*...let the brainstorming continue o jare my dear erudite Professionals...

phreakabit: https://www.nairaland.com/1852104/antiserum-cure-ebola#25387340

Thank you very much brother... I just hope our ebola patients survive. Their serum might hold the key in this fight.