Once you consume them, they can move throughout your body -- your eyes,
your tissues and most commonly your brain. They leave doctors puzzled in their wake as
they migrate and settle to feed on the body they're invading; a classic parasite, but this
one can get into your head.
"It had moved from one side of the brain to the other ... very few things move in the
brain," says Dr. Effrossyni Gkrania-Klotsas about a British man found to have a
tapeworm moving inside his brain in 2013. This form of tapeworm had never been seen
before in the United Kingdom.
The patient, who was of Chinese descent, had recently visited China, which along with
South Korea, Japan and Thailand, has more regular occurrences of the parasite known as
Spirometra erinaceieuropaei. Four years earlier the man had first experienced symptoms,
such as headaches, which the team of doctors at Addenbrookes Hospital, in Cambridge,
had treated as tuberculosis. But then he returned.
"When he reappeared, he had new symptoms," says Gkrania-Klotsas. The worm was
now pushing on a new part of his brain, causing seizures and weakness in his legs. The
condition associated with his infection was in fact Sparganosis. There is no known drug
to effectively treat the infection meaning that upon diagnosis doctors had to be quick to
remove the worm surgically.
Read: Are we closer to HIV vaccine?
Just 300 infections of the Spirometra tapeworm were recorded between 1953 and 2013,
but they're thought to be more common in parts of Asia. The rural nature of more
affected populations means numbers are widely unknown and very little is known about
the worms.
"These worms are pretty mysterious," says geneticist Hayley Bennett from the Wellcome
Trust Sanger Institute, in Cambridge, whose team r ecently sequenced the genome of the
rare worm . "We know it has a very complicated life cycle."
The adult form of the Spirometra tapeworm only occurs in the intestines of cats and
dogs but as these animals shed the worms' eggs in their feces the eggs can enter, and
contaminate, water. The resulting juvenile form of tapeworm -- known as larvae -- can
then stay in the water within certain small crustaceans or end up in frogs and snakes. As
larvae they can invade humans through ingestion or direct contact with infected animals.
The patient in Cambridge was thought to have accidentally drunk water whilst swimming
in an infected lake, according to Gkrania-Klotsas. The worm then took hold.
"The larvae can encyst in the brain or somewhere else," says Bennett. The consequences
of these cysts can be tissue damage, blindness, paralysis or even death. By sequencing
the worm's genes, Bennett hoped to understand the inner workings of the worms to aid
future diagnosis and treatment.
"Because it's such a rare infection it's not economically viable to create a drug just for
this worm," she explains. "But by comparing it to other tapeworms we can see which
other drugs might apply."
The team were given small samples of the worm, extracted from the infected patient,
and their sequencing identified an exceptionally large genome and, importantly, genes
which could help recognize resistance to drugs as well as act as future drug targets.
"You could also develop a diagnostic test," adds Bennett.
Pork tapeworms
There are many forms of tapeworm, three of which can readily infect the brain. From a
public health perspective, there's one in particular to watch out for. "It's mainly the pork
tapeworm that's the main brain one," says Helena Helmby from the London School of
Hygiene and Tropical Medicine.
The pork species, known as Taenia Solium, can infect humans in two forms. The first is
by eating undercooked pork from infected pigs, resulting in taeniasis -- an adult worm
residing in the intestine. The second, in the larval form, through contact with the feces of
an infected pig or human, which can go on to infect many tissues. If the larval worm
enters the nervous system, including the brain, it can result in a condition known as
neurocysticercosis. Infection of this kind can often cause epilepsy once inside the brain.
Almost a third of epilepsy cases in countries where the disease is native are people who
have previously had neurocysticercosis, according to the World Health Organization.
Neurocysticercosis infection arises from poor sanitation and hygiene. "You can actually
infect yourself," says Helmby, as poor hygiene, such as failing to wash your hands, could
result in you eating the eggs of an adult worm living in your intestine. "Self-infection is
common."
The global distribution of pork tapeworms is widespread with high numbers across Latin
America, Africa and Asia, according to the World Health Organization. As a result of its
higher prevalence and due to increased international travel, Gkrania-Klotsas has three
patients in her care in Cambridge who have previously experienced neurocysticercosis.
Cause for concern?
Infections with pork tapeworms are common but treatable with antihelminthic drugs
targeting the worm. Until now, treatment for Spirometra has been surgical, but the
recent genetic insight from Bennett's team in Cambridge found that some drugs, such as
praziqantil, which is used against schistosomiasis (snail fever), could have an effect.
Certain drugs used against cancer were also identified as potential treatments.
Both Helmby and Gkrania-Klotsas are concerned about risks from increased international
travel and the global food trade. "Food import and export is increasing and increasing
risks of consuming infected goods," says Helmby, who feels there is a need for more
vigilance with food inspection. She predicts more cases will occur in places like the United
Kingdom where such infections have been virtually eliminated.
"I'm confident there will be more of this in the future," agrees Gkrania-Klotsas, who has
seen patients infected without having traveled abroad. "People are getting infections
without going anywhere."
Those who do travel, however, also need greater awareness when visiting regions where
infections are commonplace. But if health teams are ready for the consequences, this
rise can be controlled.
"We need to be able to treat these infections," says Helmby. "That's the challenge at the
moment." A challenge where genetics researchers could prove invaluable, as their
sequencing continues to reveal the secrets of these parasites.

http://edition.cnn.com/2015/01/20/health/tapeworms-invade-brain/index.html

think i av som of dis in me..
whats d cure

Brain surgery ni oo