By Ellie Zolfagharifard
12:35 22 Jul 2014, updated 16:59 22 Jul 2014
Scientists used a DNA-snipping enzyme
called Cas9 to cut out the virus
The cell's gene repair machinery then
takes over, soldering the loose ends of the
genome back together – resulting in a
virus-free cell
Process could also be a cure for other
latent infections, researchers say
'It's an exciting discovery, but not ready
to go into the clinic,' said Dr Khalili
Once HIV conquers a human cell, it will stay
there forever.
It inserts its deadly genome permanently into its
victims' DNA, forcing them to require medical
treatment for the rest of their life.
But now, for the first time, researchers in
Philadelphia have found a way to completely
delete HIV from human cells by ‘snipping’ them
out.

The team of Temple University School of
Medicine said the breakthrough marks the first
successful attempt to eliminate latent HIV-1
virus from human cells – and could be a cure for
other latent infections.
MORE...
Life under the microscope: The incredible
animation that reveals an embryo growing cell
by cell
Feeling forgetful? Just ONE bad night's sleep
can have a dramatic effect on your memory,
researchers warn
‘This is one important step on the path toward a
permanent cure for AIDS,' said Kamel Khalili,
PhD, Professor and Chair of the Department of
Neuroscience at Temple.
'It's an exciting discovery, but it's not yet ready
to go into the clinic. It's a proof of concept that
we're moving in the right direction,' he added,
Temple University makes promising steps
towards cure for HIV
In a study published by the Proceedings of the
National Academy of Sciences, Dr Khalili and
colleagues detail how they created molecular
tools to delete the HIV-1 proviral DNA.
HOW THE PROCESS WORKS
Researchers based the two-part HIV-1 editor on
a system that evolved as a bacterial defence
mechanism to protect against infection.
When deployed, a combination of a DNA-snipping
enzyme called a nuclease and a targeting strand
of RNA called a guide RNA (gRNA) hunt down
the viral genome and remove the HIV-1 DNA.
Dr Khalili's lab engineered a 20-nucleotide strand
of gRNA to target the HIV-1 DNA and paired it
with a DNA-sniping enzyme called Cas9 and
used to edit the human genome.
From there, the cell's gene repair machinery
takes over, soldering the loose ends of the
genome back together – resulting in virus-free
cells.
When deployed, a combination of a DNA-snipping
enzyme called a nuclease and a targeting strand
of RNA called a guide RNA (gRNA) hunt down
the viral genome and remove the HIV-1 DNA.
From there, the cell's gene repair machinery
takes over, soldering the loose ends of the
genome back together – resulting in virus-free
cells.
'Since HIV-1 is never cleared by the immune
system, removal of the virus is required in order
to cure the disease,' explained Dr Khalili.
These molecular tools also hold promise as a
therapeutic vaccine; cells armed with the
nuclease-RNA combination proved impervious to
HIV infection.
Worldwide, more than 33 million people have
HIV, including more than 1 million in the United
States.
Every year, another 50,000 Americans contract
the virus, according to the U.S. Centers for
Disease Control and Prevention.
In the UK, around 100,000 people were living
with HIV in the UK in 2013. That’s around one
person in 665.
Although highly active antiretroviral therapy
(Haart) has controlled HIV-1 for infected people
in the developed world over the last 15 years, the
virus can rage again with any interruption in
treatment.
'The low level replication of HIV-1 makes
patients more likely to suffer from diseases
usually associated with ageing,' Dr Khalili said.
These include cardiomyopathy – a weakening of
the heart muscle – bone disease, kidney disease,
and neurocognitive disorders.
'These problems are often exacerbated by the
toxic drugs that must be taken to control the
virus,' Dr Khalili added.
Researchers based the two-part HIV-1 editor on
a system that evolved as a bacterial defence
mechanism to protect against infection.
Dr Khalili's lab engineered a 20-nucleotide strand
of gRNA to target the HIV-1 DNA and paired it
with a DNA-sniping enzyme called Cas9 and
used to edit the human genome.
'We are working on a number of strategies so we
can take the construct into preclinical studies,'
Dr Khalili said.
'We want to eradicate every single copy of HIV-1
from the patient. That will cure AIDS. I think this
technology is the way we can do it.

nicko92:

By Ellie Zolfagharifard
12:35 22 Jul 2014, updated 16:59 22 Jul 2014
Scientists used a DNA-snipping enzyme
called Cas9 to cut out the virus
The cell's gene repair machinery then
takes over, soldering the loose ends of the
genome back together – resulting in a
virus-free cell
Process could also be a cure for other
latent infections, researchers say
'It's an exciting discovery, but not ready
to go into the clinic,' said Dr Khalili
Once HIV conquers a human cell, it will stay
there forever.
It inserts its deadly genome permanently into its
victims' DNA, forcing them to require medical
treatment for the rest of their life.
But now, for the first time, researchers in
Philadelphia have found a way to completely
delete HIV from human cells by ‘snipping’ them
out.

The team of Temple University School of
Medicine said the breakthrough marks the first
successful attempt to eliminate latent HIV-1
virus from human cells – and could be a cure for
other latent infections.
MORE...
Life under the microscope: The incredible
animation that reveals an embryo growing cell
by cell
Feeling forgetful? Just ONE bad night's sleep
can have a dramatic effect on your memory,
researchers warn
‘This is one important step on the path toward a
permanent cure for AIDS,' said Kamel Khalili,
PhD, Professor and Chair of the Department of
Neuroscience at Temple.
'It's an exciting discovery, but it's not yet ready
to go into the clinic. It's a proof of concept that
we're moving in the right direction,' he added,
Temple University makes promising steps
towards cure for HIV
In a study published by the Proceedings of the
National Academy of Sciences, Dr Khalili and
colleagues detail how they created molecular
tools to delete the HIV-1 proviral DNA.
HOW THE PROCESS WORKS
Researchers based the two-part HIV-1 editor on
a system that evolved as a bacterial defence
mechanism to protect against infection.
When deployed, a combination of a DNA-snipping
enzyme called a nuclease and a targeting strand
of RNA called a guide RNA (gRNA) hunt down
the viral genome and remove the HIV-1 DNA.
Dr Khalili's lab engineered a 20-nucleotide strand
of gRNA to target the HIV-1 DNA and paired it
with a DNA-sniping enzyme called Cas9 and
used to edit the human genome.
From there, the cell's gene repair machinery
takes over, soldering the loose ends of the
genome back together – resulting in virus-free
cells.
When deployed, a combination of a DNA-snipping
enzyme called a nuclease and a targeting strand
of RNA called a guide RNA (gRNA) hunt down
the viral genome and remove the HIV-1 DNA.
From there, the cell's gene repair machinery
takes over, soldering the loose ends of the
genome back together – resulting in virus-free
cells.
'Since HIV-1 is never cleared by the immune
system, removal of the virus is required in order
to cure the disease,' explained Dr Khalili.
These molecular tools also hold promise as a
therapeutic vaccine; cells armed with the
nuclease-RNA combination proved impervious to
HIV infection.
Worldwide, more than 33 million people have
HIV, including more than 1 million in the United
States.
Every year, another 50,000 Americans contract
the virus, according to the U.S. Centers for
Disease Control and Prevention.
In the UK, around 100,000 people were living
with HIV in the UK in 2013. That’s around one
person in 665.
Although highly active antiretroviral therapy
(Haart) has controlled HIV-1 for infected people
in the developed world over the last 15 years, the
virus can rage again with any interruption in
treatment.
'The low level replication of HIV-1 makes
patients more likely to suffer from diseases
usually associated with ageing,' Dr Khalili said.
These include cardiomyopathy – a weakening of
the heart muscle – bone disease, kidney disease,
and neurocognitive disorders.
'These problems are often exacerbated by the
toxic drugs that must be taken to control the
virus,' Dr Khalili added.
Researchers based the two-part HIV-1 editor on
a system that evolved as a bacterial defence
mechanism to protect against infection.
Dr Khalili's lab engineered a 20-nucleotide strand
of gRNA to target the HIV-1 DNA and paired it
with a DNA-sniping enzyme called Cas9 and
used to edit the human genome.
'We are working on a number of strategies so we
can take the construct into preclinical studies,'
Dr Khalili said.
'We want to eradicate every single copy of HIV-1
from the patient. That will cure AIDS. I think this
technology is the way we can do it.

link to the thread above is to let me paste it people

...And when we request for the procedure in africa they'll say we should continue dying for a little more time

Welcome developement.

snipping out HIV?? hmmm... ok o nice improvements. after snipping they will solder the genomes... sounds 50 50 chance of survival