AA and AS parents can have an SC Child: Genotype Possibilities - Health - Nairaland
Nairaland Forum / Nairaland / General / Health / AA and AS parents can have an SC Child: Genotype Possibilities (2697 Views)
A Reply To The Topic: It Is Possible For AA And AS Couple To Have An SS Child / Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS' / Why You Should Know Your Genotype Before Considering Getting Married (2) (3) (4)
| AA and AS parents can have an SC Child: Genotype Possibilities by aimeeworship: 9:38pm On Jun 26, 2015 |
It is possible to be SC when the mother is AA and the father is AS. Most electrophoretic genotype machines used in routine laboratory only ascertain the A, S, C and rarely F bands based on the quality of the band. There are different sub-types: adult haemoglobin (Hb A), minor adult haemoglobin (Hb A2), sickle haemoglobin ( Hb S or C caused by a variant of the beta -globin gene) and foetal haemoglobin (Hb F is usually present in foetus and remains up to 6 months after birth). NOTE: There are other variables. Hb S or C are the mutated form which reduces the normal plasticity of host erythrocytes (red blood cell) causing hemoglobinopathy (abnormality in the blood). Patients with Hb SS and Hb SC give similar clinical presentation. Using the high performance liquid chromatography (HPLC) machine (mostly seen in research labs) gives the genotype result based on quantity and often indicated in percentage. Every individual having either Hb AA, AS, AC, SS and SC have other subgroups but in minor percentage. For example, Mum: may have Hb A as 41%, Hb A2 as 30%, Hb C as 23%, Hb S as 5% and Hb F as 1%. The two Hb with the highest percentage value is taken as the genotype = HbAA Dad: may have Hb A as 37%, Hb S as 29%, Hb C as 25%, Hb C as 7% and Hb A2as 2%. The two Hb with the highest percentage value is taken as the genotype = HbAS Child: The genetic combination at which the genotype is obtained is random (I think God alone knows the perfect combination) but it revolves within these percentages written above for the parents. The child may have Hb S as 34%, Hb C as 30%, Hb A as 24%, Hb A2 as 11% and Hb F as 1%. The two Hb with the highest percentage value is taken as the genotype = Hb SC With this illustration, the child could have the other Hb variables but in minimal amount. Regular laboratory tests will not give this details. Any need for HPLC tests, I can ... . ? Working in a research laboratory where this is currently carried out prompted me to write especially with the so-called genetic knowledge given by so many persons on different threads. cc: @Leem4 @lalasticlala |
| Re: AA and AS parents can have an SC Child: Genotype Possibilities by donholy28(m): 10:02pm On Jun 26, 2015 |
Ur papa don use style do AS woman...and dem born SS...ask ur parents |
| Re: AA and AS parents can have an SC Child: Genotype Possibilities by Infomizer(m): 10:46pm On Jun 26, 2015 |
Thanks for the insight op! 2 Likes |
| Re: AA and AS parents can have an SC Child: Genotype Possibilities by iamclime(m): 10:06pm On Nov 15, 2023 |
This is informative and concise. Learnt of someone somewhere.who is SC and has an AA sibling from the same parents. This kind of sums it up. Thanks OP. |
| Re: AA and AS parents can have an SC Child: Genotype Possibilities by Akposkiz: 8:59pm On Nov 16, 2023 |
Nice Educative! Pls what is the solution to it !! |
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