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MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' - Health - Nairaland

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MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by Nobody: 8:23am On Nov 24, 2015
When I come across news like this, I just wanna shout, EUREKA!


US scientists say they have bred a genetically modified (GM) mosquito that can resist malaria infection.
If the lab technique works in the field, it could offer a new way of stopping the biting insects from spreading malaria to humans, they say.
The scientists put a new "resistance" gene into the mosquito's own DNA, using a gene editing method called Crispr.
And when the GM mosquitoes mated - their offspring inherited the same resistance, PNAS journal reports.
In theory, if these mosquitoes bite people, they should not be able to pass on the parasite that causes malaria.
About 3.2bn people - almost half of the world's population - are at risk of malaria.
Bed nets, insecticides and repellents can help stop the insects biting and drugs can be given to anyone who catches the infection, but the disease still kills around 580,000 people a year.
'Pivotal role'
Scientists have been searching for new ways to fight malaria.
The University of California team believe their GM mosquito could play a pivotal role - breeding resistant offspring to replace endemic, malaria-carrying mosquitoes.
They took a type of mosquito found in India - Anopheles stephensi - on which to experiment.
Dr Anthony James and his team showed that they could give the insect new DNA code to make it a poor host for the malaria parasite.
The DNA, which codes for antibodies that combat the parasite, was inherited by almost 100% of the mosquito offspring and across three generations.
Genetically modified mosquito larvaeImage copyrightScience Photo Library
Image caption
Mosquito larvae can be genetically modified to carry 'useful' new genes, such as resistance to the Plasmodium parasites that cause malaria
The researchers say the findings offer hope that the same method could also work in other mosquito species.
Although it would not be a sole solution to the malaria problem, it would be a useful additional weapon, they say.
Prof David Conway, UK expert from the London School of Hygiene & Tropical Medicine, said: "It's not the finished product yet but it certainly looks promising. It does look like the genetic editing works."
Other scientists have been looking at genetically modifying mosquitoes to render them infertile, so that they die out. But some experts fear that eliminating mosquitoes entirely may have unforeseen and unwanted consequences. Replacing disease-carrying mosquitoes with harmless breeds is a potential alternative.
http://www.bbc.com/news/health-34898931

Re: MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by Folksyharry(m): 8:35am On Nov 24, 2015
I just read it this morning. If it works well outside the lab it will be very helpful especially for African countries
Re: MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by iykmora(m): 8:37am On Nov 24, 2015
they should engineer these 'SKEETS' to look away from d human body from their feeding also. The most annoying is d 'weeeeiiiinnnnng' siren noise dem dey make for we ear. F^ckin irritants!
Re: MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by Nobody: 2:05pm On Nov 24, 2015
iykmora:
they should engineer these 'SKEETS' to look away from d human body from their feeding also. The most annoying is d 'weeeeiiiinnnnng' siren noise dem dey make for we ear. F^ckin irritants!
Hehwhen misquitoes would always be mosquitoes. But jeez, those ringing noise they make could be mighty irritating.
Re: MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by Nobody: 2:06pm On Nov 24, 2015
Folksyharry:
I just read it this morning. If it works well outside the lab it will be very helpful especially for African countries
For once we are soo close to a breakthrough.
Re: MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by Kingbilo(m): 4:04pm On Nov 24, 2015
This is cool.. Hope malaria doesn't fight back with a "mutant resistant strain" grin

These days all I hear about is antibiotics ushering in a post antibiotic era of disease... Seems while scientists are concocting in the lab, infections are also concocting their own defence

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Re: MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by Nobody: 7:43pm On Nov 24, 2015
Kingbilo:
This is cool.. Hope malaria doesn't fight back with a "mutant resistant strain" grin

These days all I hear about is antibiotics ushering in a post antibiotic era of disease... Seems while scientists are concocting in the lab, infections are also concocting their own defence....
Super bugs. The antibiotics/infection war cannot be won. At least until scientists find a way to stop antigens from molecular mimicry.
Re: MALARIA BREAKTHROUGH :mutant Mosquitoes 'resist Malaria' by Kingbilo(m): 8:31pm On Nov 24, 2015
sapiosexual1:

Super bugs. The antibiotics/infection war cannot be won. At least until scientists find a way to stop antigens from molecular mimicry.

Yeah.. I'm surprised a single mosquito can be bred to resist all the different strains of malaria out there..

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