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Diabetes Insipidus by olsamlaw(m): 12:41am On May 01, 2016 |
Diabetes insipidus ( DI) is a condition
characterized by excessive thirst and excretion
of large amounts of severely dilute urine, with
reduction of fluid intake having no effect on the
concentration of the urine. [1] There are
different types of DI, each with a different set
of causes. The most common type in humans
is the neurological form, called central DI
(CDI), which involves a deficiency of arginine
vasopressin (AVP), also known as antidiuretic
hormone (ADH). The second common type of
DI is nephrogenic diabetes insipidus (NDI),
which is due to kidney or nephron dysfunction
caused by an insensitivity of the kidneys or
nephrons to ADH. DI can also be gestational,
or caused by alcohol or some types of drug
abuse. DI should not be confused with
nocturia .
Although they have a common name, diabetes
mellitus and diabetes insipidus are two entirely
separate conditions with unrelated
mechanisms. Both cause large amounts of
urine to be produced ( polyuria ). However,
diabetes insipidus is either a problem with the
production of antidiuretic hormone (central
diabetes insipidus) or kidney's response to
antidiuretic hormone (nephrogenic diabetes
insipidus), whereas diabetes mellitus causes
polyuria via a process called osmotic diuresis ,
due to the high blood sugar leaking into the
urine and taking excess water along with it. source:Wikipedia. com |
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