Water technique is for the supreme evaluation (aqua proteomics) of proteins and their change states. Peptides are combined with consolidated stable isotopes as perfect inside principles to copy local peptides shaped by proteolysis. These manufactured peptides can likewise be set up with covalent changes (e. g. , phosphorylation, methylation, acetylation, and so on.) that are synthetically indistinguishable to normally happening posttranslational adjustments.