Ebola is a frightening, highly lethal virus — in the current outbreak in West Africa, about 60 percent of people infected with the pathogen have died. Although in the minority, some people do recover from infection.


Doctors don't know for certain who will survive Ebola, and there is no specific treatment or cure for the disease. But studies suggest there are some biological markers linked with a higher chance of surviving Ebola, experts say.

When a person becomes infected with Ebola, the virus depletes the body's immune cells, which defend against infection, said Derek Gatherer, a bioinformatics researcher at Lancaster University in the United Kingdom, who studies viral genetics and evolution. In particular, the Ebola virus depletes immune cells called CD4 and CD8 T lymphocytes, which are crucial to the function of the immune system, Gatherer said. [5 Things You Should Know About Ebola]

But if a person's immune system can stand up to this initial attack — meaning their immune cells are not as depleted in the first stages of infection — then studies suggest they are more likely to survive the disease.

"The patients that survive it best are the ones who don't get such a bad [immune] deficiency," Gatherer told Live Science.

But if the body is not able to fend off this attack, then the immune system becomes less able to regulate itself, Gatherer said. This means the immune system is more likely to run out of control and release a "storm" of inflammatory molecules, which cause tiny blood vessels to burst, leading in turn to a drop in blood pressure, multi-organ failure and eventually death.

The current Ebola outbreak — which is in Guinea, Sierra Leone and Liberia — has infected at least 1,603 people, including 887 who have died, according to the World Health Organization, making it the largest outbreak in history.

Another marker linked with people's ability to survive Ebola is a gene called human leukocyte antigen-B, which makes a protein that is important in the immune system. A 2007 study found that people with certain versions of this gene, called B*07 and B*14, were more likely to survive Ebola, while people with other versions, called B*67 and B*15, were more likely to die.

Finally, some people may be resistant to Ebola infection entirely, if they have a mutation in a gene called NPC1. Studies show that, when researchers take cells from people with the NPC1 mutation and try to infect them with Ebola in a laboratory dish, these cells are resistant to the virus.

In European populations, about 1 in 300 to 1 in 400 people have this mutation, Gatherer said. But in some populations, this mutation is more common: in Nova Scotia, between 10 and 26 percent of people have this mutation, Gatherer said. But the frequency of this mutation in African populations is not known, he said.

However, because these studies on Ebola resistance were done in a lab, it's not known for certain if carriers of the NPC1 are truly resistant to Ebola.

Gatherer said that, hopefully, samples are being collected in the current outbreak so that researchers can conduct studies to better understand the virus and how to survive it.

https://www.yahoo.com/news/people-survive-ebola-233906237.html

Hm!

Eat Bitter Kola...


Simple!!

No wonder this morning I take bus say make I go hustle for Allen Avenue despite my catarrh...

As I sneeve once, heeeshian! Three people hala "driver owaa oh!!"

As I sneeve again, hhheeeheeeheeehehhshian!! Other Passengers including Driver and Conductor follow disappear leave me alone for bus...

I begin wida na!!

.

hmmm

LUCK!

To know how the deadly ebola virus kills check

www.healthlineafrica.com/how-ebola-kills

OkikiOluwa1: Hm!

How did you manage to beat me to FTC position ?

Immunity is the answer.

Lord have mercy on us all. Read Shocking Ebola facts here: www.9u0f2h85mi and you will know that we need to keep praying more and more.

all we need is the grace of GOD

ask me

SIMPLE
#rollbackebola

hmmmmm!
ENDTIME THINGS

BrAkingNews: g

wats g for

May God help us...AMEN!!!

guess its gene adhesive

but from what i see, if we dont contain the virus soon,it may mutate or evolve.

think, it started from bats( lie from hell), now its on the highest hierarchy of creation!

WHITES!!! have u seen ur lab experimental error

tell me: whats the diff between trojan and ebola? electronic and organic.
tell me: whats the same with trojan and ebola? man made

Prevention is better than cure.
Just do whatever possible to prevent yourself.
My1cedi

MyPWisINCORRECT: No wonder this morning I take bus say make I go hustle for Allen Avenue despite my catarrh...

As I sneeve once, heeeshian! Three people hala "driver owaa oh!!"

As I sneeve again, hhheeeheeeheeehehhshian!! Other Passengers including Driver and Conductor follow disappear leave me alone for bus...

I begin wida na!!

not funny

it may not even be about surviving or not.for me,the fear and stigma of contracting that virus is enough hell for a victim.it's indeed a terrible situation.

kai,, pains

If you have Ebola.. Go to Nigeria market. Our local common herbs will cure it..bleep to those who wants to spoil the image of our herbs. #OUR HERBS,OUR PRIDE.

Africans are infected by the thousand (and subsequently dying), they say there is no cure!!!!!
US doctor in Liberia get infected, they are given a "miracle cure and sent to the US to follow the treatment on that "miracle fukcing cure"!!!!

the medicine is called Zmapp, and they had it in Liberia but supposedly, our African brothers were not important enough to get it.
MAY THEY GET PUNISHED!!!!!!

9jahubcom: wats g for

nah goat my brother

PREVENTION IS BETTER THAN CURE

ACT NOW!!!

Avoid areas of known outbreaks. Before traveling to Africa, find out about current epidemics by checking the Centers for Disease Control and Prevention website.

Wash your hands frequently. As with other infectious diseases, one of the most important preventive measures is frequent hand-washing. Use soap and water, or use alcohol-based hand rubs containing at least 60 percent alcohol when soap and water aren't available.

Avoid bush meat. In developing countries, avoid buying or eating the wild animals, including nonhuman primates, sold in local markets.
Avoid contact with infected people. In particular, caregivers should avoid contact with the person's body fluids and tissues, including blood, semen, vaginal secretions and saliva. People with Ebola or Marburg are most contagious in the later stages of the disease.

Follow infection-control procedures. If you're a health care worker, wear protective clothing, such as gloves, masks, gowns and eye shields. Keep infected people isolated from others. Dispose of needles and sterilize other instruments.
Don't handle remains. The bodies of people who have died of Ebola or Marburg disease are still contagious. Specially organized and trained teams should bury the remains, using appropriate safety equipment.

ibereh

Excellent article....very good.

Here is some detailed scientific reasons ....based on a study done in Gabon....repeated in this paper

A comparison of immune parameters in survivors and nonsurvivors of infection has provided clues into the constituents of an effective immune response. Baize et al. (2) characterized the immune responses of patients in two large Ebola virus outbreaks in Gabon in 1996. There was no significant difference in viral antigen load between survivors and nonsurvivors, but immune responses varied, suggesting that survival is dependent on the initial or innate immune response to infection. Survivors exhibited more significant IgM responses, clearance of viral antigen, and sustained T-cell cytokine responses, as indicated by high levels of T-cell-related mRNA in the peripheral blood. In contrast, antibodies specific for the virus were nearly undetectable in fatal cases, and while gamma interferon (IFN-γ) was detected early after infection, T-cell cytokine RNA levels were more indicative of a failure to develop adaptive immunity in the days preceding death.

During infection, there is evidence that both host and viral proteins contribute to the pathogenesis of Ebola virus. Increases in the levels of inflammatory cytokines IFN-γ, IFN-α, interleukin-2 (IL-2), IL-10, and tumor necrosis factor alpha were associated with fatality from Ebola hemorrhagic fever (40). Moreover, in vitro experiments demonstrated that tumor necrosis factor released from filovirus-infected monocytes and macrophages increased the permeability of cultured human endothelial cell monolayers (12). However, other reports have observed an association between elevated levels of IFN-γ mRNA and protection from infection (2), and a protective effect of IFN-α and -γ is suggested by the fact that the virus has evolved at least one protein, VP35, that acts as an IFN-α/β antagonist (5). Whether the effects of cytokines are protective or damaging may depend not only on the cytokine profile but also may represent a delicate balance influenced by the route and titer of incoming virus as well as factors specific to the individual host immune response.

Also, humans with cells that are defective in Niemman-Pick receptors (NPC-1) are resistiant to ebola..as this study says..

[b]Cells defective for the HOPS complex or NPC1 function, including primary fibroblasts derived from human Niemann-Pick type C1 disease patients, are resistant to infection by EboV and MarV, [/b]but remain fully susceptible to a suite of unrelated viruses. We show that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment requires the NPC1 protein, independent of its known function in cholesterol transport. Our findings uncover unique features of the entry pathway used by filoviruses and suggest potential antiviral strategies to combat these deadly agents.