Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? - Health (6) - Nairaland
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Is It Possible For A Hiv Positive Man Not To Pass It To His Wife? / Help! His Genotype Is AA And His Wife's Genotype Is AS But Their Daughter is SS / Please Explain Genotype AA (2) (3) (4)
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| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Pope22(m): 5:16pm On Jun 26, 2015 |
dedugbaa:Just listen to yourself, a PG student for that matter. She hasn't even gone for the test yet and you have already concluded she is not their biological daughter. Haven't you heard of mutation before where AA and AA can have AS, AA and AS can have SS? Can you people please stop confusing this young pretty girl and turning her against her lovely parents? 2 Likes 2 Shares |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by soleexx(m): 5:16pm On Jun 26, 2015 |
You have only 1 solution Bro...DNA!! |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by nervorum: 5:20pm On Jun 26, 2015 |
adamshuaib: SC exists..sickle cell disease is a spectrum of blood genotype disorders, ranging from ss,sc sthal, Bthal etc..SS is commoner and more clinically severe than SC |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by ACM10: 5:20pm On Jun 26, 2015 |
Leem4: There are two scenarios that can make your story possible. . . 1. Mistake in assigning the wrong blood genotype to the wrong person. This is not uncommon in Nigeria. In fact, I've met several cases of it. 2. There is a phenomenon called a new onset mutation. In which there is a mutation in the germ cell of the gene coding for the blood genotype in a previously normal individual. The person will be normal, but can produce SC offspring when matched with another carrier. |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by exco90(m): 5:22pm On Jun 26, 2015 |
Leem4: Oga go and tell ur mum to produce ur father.. Tell ur mum that her 20years old punded yam.. Is still hot.. Tell her to reveal the skeleton in her cupboard.. |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by ACM10: 5:23pm On Jun 26, 2015 |
Pope22: On point.  |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Gurgle(f): 5:23pm On Jun 26, 2015 |
Leem4: [size=16pt]There is something called "chimerism" Sometimes in the womb there may be twins But for some reason or the other the twins merge together and form one person That means the person who is born will have a mixture of cells from two different people, although they were born as one person Your mother may be such a person Her blood cells may be AA whilst the cells she used to give birth to you were AS[/size] 3 Likes |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by tokaiki: 5:25pm On Jun 26, 2015 |
Here is an indepth analysis of the common forms of genotype. All intending couples should take note. It is better to be safe than sorry. The AS AC SC SS and CC genotype. What you have in your blood are cells, the most predominant of which are called RED BLOOD CELLS (RBCs). These cells contain within them HEMOGLOBIN, a substance without which the RBCs are invariably useless. This hemoglobin itself is composed of 2 parts: a heme (don't bother yourself, this basically is a complex Iron-protein complex) and globin (2 pairs of protein chains, this is the important part). There are 2 alpha and 2 beta globin chains - the pair, and there is a normal way the chains are supposed to be structured. The error happens when a protein substitution occurs in any one of these chains - but particularly in the globin chains (First of all, you have to understand that amino acids are the building blocks of proteins - so if amino acid 'x' is the normal, an abnormality occurs when instead of 'x' at a particular location along the chain, you have 'y'.) That is as simple as it gets. These errors of substitution are given the big name of 'THALASSAEMIAS'. In reality, a substitution will occur at any point along either the alpha or beta chains but for the purposes of simplicity and to answer your question, we focus on the genotypes AS, SS, AC. Genotype AA: At position 6 of both globin chains,the amino acid is GLUTAMATE Genotype AS: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have VALINE Genotype SS: At position 6 of both globin chains, the amino acid is VALINE Genotype AC: At position 6 of one globin chain is GLUTAMATE and at position 6 of the second globin chain, you have LYSINE There are different types of Hemoglobin; among them are Hemoglobin A, Hemoglobin S and Hemoglobin C. Hemoglobin C is very rare. Everyone must have a pair of these hemoglobin in their blood, each inherited from both parents. The pairing might be in any of the following formations: AA, AS, AC, SC,SS OR CC. A man with AA can marry any one without any problem (medically); likewise the woman. How do people get their genotypes? Simple, from your biological parents. If papa bomboy has a genotype AA and mama bomboy has a genotype AS, which genotype do their children have? What we do in theory is this, you cross each of those letters so that you have AA, AS, AA, AS? Therefore, for each pregnancy and each bomboy they delivery has a 50:50 probability of being AA or AS. What if their genotypes were AA (for papa bomboy) and SS (for mama bomboy); you do the crossing again: AS, AS, AS, AS. Therefore, it is very UNLIKELY that any of their children will have a genotype outside of AS. You will see that I have used the word unlikely because poo happens. They might end up having a child who is either completely AA or SS but whatever happens, a child's genotype is never outside of the parents. Eg. a man and woman who are both AA can never have children with genotype starting or ending with 'S'. If it happens, either your landlord or next door neighbours are highly involved (just kiddin Oluwa isn't involved'). So for you to get C, you must have a parent who carries a 'C' in his or her genotype. Likewise the S must have a parent with S genotype One more thing: Are there any clinical features of Hemoglobin C like Hemoglobin S? In the case that you're AC, well the good news is that MOST TIMES THERE ARE NO SYMPTOMS, but occasionally, there is JAUNDICE. THE BEST PART IS THAT YOU CAN LIVE A NORMAL LIFE WITH AC!!! And just for the case of mentioning genotypes, you could have: Regular Genotype: AA (healthy as healthy can be) Traits: AC, AD, AF, AG, A+FAST, AE and AS (not associated with any clinical signs, symptoms or syndromes - they as relatively as healthy as AA) Genotypes associated with clinical features: SS, SC, CC (are associated with clinical signs, symptoms and syndromes) •Please note that the marriage thing is this, we really don't know what the recent trend is but the important thing is to make sure your genotype of you and your partner don't match up in a way as to produce children with SS, SC and CC. These children only suffer for nothing!!! You can't even begin to compare the differences in severity between CC and SS disease. Symptoms of Hemoglobin C dsx (CC) Most people do not have symptoms. Occasionally, jaundice may occur. Complications of Hemoglobin C dsx Sometimes, they may experience the following: Cholelithiasis (gall stones that may require treatment) Splenomegaly (big spleen) Angloid streaks (causing poor vision) Aplastic crises (due to viral infection): episode of severe anemia Treatment There is no treatment. Folic acid supplementation is required to help the body with red blood cell production and improve symptoms of anemia. Prognosis Note that unlike the Hemoglobin S dsx (SS), pxts with Hemoglobin C dsx have a normal life expectancy, Before we forget, what about SC genotype? Please note the following: AA: normal pxts AS: don't show any symptoms SS: sickle cell disease (sicklers) AC: don't show any symptoms CC: described above SC? This condition is associated with recurrent anemia (breakdown of red cells in the blood vessels) and pain crises (vaso-occlusive crises). Some may also experience aseptic necrosis of the thigh bone (femur). Summary is that it is bad, One thing you must understand is that in terms of geographic distribution, the hemoglobin C allele is found at the highest frequencies in West Africa and it has been associated with protection against malaria. A good number of people have the C allele but are unaware of it. Also note that most people with the AC genotype show no symptoms, PLEASE NOTE THIS AND HELP SHARE WITH A FRIENd A man or woman with AS or AC or SS or SC or CC (very rare) cannot marry each other, if they want to avoid SS or SC. They must marry a partner with AA, if they don't want to born a child with Sickle call syndrome. If AS or AC marry each other, they have 25% chance of having a sickle child at every birth. If they marry SS or SC, they have 50% chance of having a sickle cell child at every birth. Please note all their kids could be AS AC or AA. If SS or SC marry each other, it's is nothing other than a terrible disaster. All their children will have Sickle cell SC and SS are almost the same only that SS suffers more severe crisis than SC carrier. You might not notice the presence of the disease on the body of SC carrier, unlike in SS. Solution The only thing that can change the genotype is an intentional act like BMT. Bone Marrow transplant technology has been proven to be the only permanent cure to SS SC and CC; however, it is new, very expensive and cannot be done in any part of Africa, and carries some risks. Naturally, environment or time cannot change genotype. Please Note: Divine Miracles can change it as well - it has happened in so many part of the world. Again, some SS carriers may start experiencing crisis at late age (as late as 40s). If these sets of people go for test in a quack lab, definitely the lab technician will assume AA or AS since the person is not having the symptom. Later in life it will become obvious when the symptom have come up, and another lab technician will report SS. To all unmarried folks, please know your genotype and that of your spouse. Only people with AA genotype can marry people of other genotype AC AS SC SS or CC without any medical complication. Culled from Laumsites Ywc facebook page. 1 Like |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by tunesoft(m): 5:25pm On Jun 26, 2015 |
It a certain percentage of births...non-concordance is possible...please do some research to confirm before you scatter a family. |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by mkpikpub(m): 5:28pm On Jun 26, 2015 |
Leem4: Ask them again whether they are your parents or whether you were adopted. Hard facts |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by fabiyi78(m): 5:29pm On Jun 26, 2015 |
Bro u av said it all because there is no genotipical evidence to back it up. OP God wil grant you Good health. If d op can go further pls carry out ur DNA test MummyEsther: |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 5:31pm On Jun 26, 2015 |
Leem4:Op we are in same category, sometimes I just feel like killing them, now they have separated and live me alone with my grandmother, well now am 30,but sometimes I don't feel happy at all. 1 Like |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Immarocks(f): 5:32pm On Jun 26, 2015 |
Drsmiles:. please enlighten us....I've never heard of SC genotype b4.... |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 5:33pm On Jun 26, 2015 |
alabiyemmy:even a AA mum shouldn't/couldn't av an SS baby |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 5:33pm On Jun 26, 2015 |
alabiyemmy:even a AA mum shouldn't/couldn't av an SS baby. I tire for this. |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by MrOlai: 5:34pm On Jun 26, 2015 |
MrOlai: |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Forwetinnah: 5:35pm On Jun 26, 2015 |
phyllosilicate: My thoughts too... |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by jdula: 5:35pm On Jun 26, 2015 |
[b]I have similar issue, I even wanted to create a thread to seek Nairalanders help on it. My own case, my dad is AA and my Mom AS, Is a large family of eight children and am the only one who have this blood disorder. I started having crisis when I was young though, which resulted to series of test carried four times to be precise, three of which came out as As and the last one which I was referred to a General Hospital was what came out SS. its been like seven years or more now I have not visited any hospital for anything relating to crisis, whenever anything like pains comes up in my joint I just take a pain relief and am back again, if the painkiller doesn't work well I know I might have malaria, after treating the malaria am back again. My point is this, why will three different text prove negative and just one prove positive? And why have I been experiencing less crisis? (Will attribute this God anyway) Why am I the only one in this family of eight children to have the disorder? Please reasonable answer from any one who knows better. Thanks[/b] |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Acebar(m): 5:37pm On Jun 26, 2015 |
@Op, your dad is ur biological father except proved otherwise by a DNA test. But there was a GENE MUTATION during the time you were in the womb. gene mutation is a permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people. Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes. Gene mutations can be classified in two major ways: Hereditary mutations are inherited from a parent and are present throughout a person’s life in virtually every cell in the body. These mutations are also called germline mutations because they are present in the parent’s egg or sperm cells, which are also called germ cells. When an egg and a sperm cell unite, the resulting fertilized egg cell receives DNA from both parents. If this DNA has a mutation, the child that grows from the fertilized egg will have the mutation in each of his or her cells. Acquired (or somatic) mutations occur at some time during a person’s life and are present only in certain cells, not in every cell in the body. These changes can be caused by environmental factors such as ultraviolet radiation from the sun, or can occur if a mistake is made as DNA copies itself during cell division. Acquired mutations in somatic cells (cells other than sperm and egg cells) cannot be passed on to the next generation. Genetic changes that are described as de novo (new) mutations can be either hereditary or somatic. In some cases, the mutation occurs in a person’s egg or sperm cell but is not present in any of the person’s other cells. In other cases, the mutation occurs in the fertilized egg shortly after the egg and sperm cells unite. (It is often impossible to tell exactly when a de novo mutation happened.) As the fertilized egg divides, each resulting cell in the growing embryo will have the mutation. De novo mutations may explain genetic disorders in which an affected child has a mutation in every cell in the body but the parents do not, and there is no family history of the disorder. Somatic mutations that happen in a single cell early in embryonic development can lead to a situation called mosaicism. These genetic changes are not present in a parent’s egg or sperm cells, or in the fertilized egg, but happen a bit later when the embryo includes several cells. As all the cells divide during growth and development, cells that arise from the cell with the altered gene will have the mutation, while other cells will not. Depending on the mutation and how many cells are affected, mosaicism may or may not cause health problems. Most disease-causing gene mutations are uncommon in the general population. However, other genetic changes occur more frequently. Genetic alterations that occur in more than 1 percent of the population are called polymorphisms. They are common enough to be considered a normal variation in the DNA. Polymorphisms are responsible for many of the normal differences between people such as eye color, hair color, and blood type. Although many polymorphisms have no negative effects on a person’s health, some of these variations may influence the risk of developing certain disorders. |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 5:39pm On Jun 26, 2015 |
ABIO,THE GUY IS JUST WOORRYINTG HIMSELF . Bluetooth2: |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by arsetalks(m): 5:40pm On Jun 26, 2015 |
adamshuaib:About 4 more genotypes have been discovered and this includes SC, AC, CC and one other. Google is your friend. 1 Like |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by kclein(m): 5:48pm On Jun 26, 2015 |
1) Were d test accurately done? 2) Any foul play after delivery by d nurses? 3)Any secret btwn ur parents or each of dem on how u came into dis world? |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by kclein(m): 5:49pm On Jun 26, 2015 |
1) Were d tests accurately done? 2) Any foul play after delivery by d nurses? 3)Any secret btwn ur parents or each of dem on how u came into dis world? |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by arsetalks(m): 5:50pm On Jun 26, 2015 |
writetopoker:Babe sorry but not everything is a laughing matter. Imagine the pain the OP must be going throug now. |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by mezebel(f): 5:51pm On Jun 26, 2015 |
laralabelle:God bless u. |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Oswenemete(f): 5:54pm On Jun 26, 2015 |
[color=#006600][/color] |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Oswenemete(f): 6:01pm On Jun 26, 2015 |
[i][/i]My brother I have read a case like yours when studying about this SC ,for the first time on my practice in the field,its actually true that SC exist and what caused you to be SC instead AS is the deficiency on the haemoglobin protein strand so instead the complete As, you lack the one strand making it SC.just as the case of a person having TYPE SYNDROME and DOWN SYNDROMEMy brother I have read a case like yours when studying about this SC ,for the first time on my practice in the field,its actually true that SC exist and what caused you to be SC instead AS is the deficiency on the haemoglobin protein strand so instead the complete As, you lack the one strand making it SC.just as the case of a person having TYPE SYNDROME and DOWN SYNDROMEMy brother I have read a case like yours when studying about this SC ,for the first time on my practice in the field,its actually true that SC exist and what caused you to be SC instead AS is the deficiency on the haemoglobin protein strand so instead the complete As, you lack the one strand making it SC.just as the case of a person having TYPE SYNDROME and DOWN SYNDROME 2 Likes |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Davivah: 6:07pm On Jun 26, 2015 |
adamshuaib: There is SC arising from AC n AS .pls dont confuse people here, ask your Doc n google it 1 Like |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 6:09pm On Jun 26, 2015 |
Genotypic Mutation 1 Like |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Maximus85(m): 6:10pm On Jun 26, 2015 |
Leem4: You said your dad is AC |
| Re: Is it Possible for a AA genotype to give birth to SC.. Are They My Parents? by Nobody: 6:10pm On Jun 26, 2015 |
Leem4: "My son, don't be angry with me, your dad was not performing and I decided to to to... *crying*. You are the landlord's son. *crying heavily* |
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