₦airaland Forum

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

jnrremedy:
being a doctor doesn't mean u know everything pls go and update ur knowledge of hemoglobin defects or simply visit sickle cell center in igbobi Lagos.
and yes it is very very possible for a AA and AS couple to give birth to a sickler though not the SS sickler (but electrophoresis will read the genotype as SS)
a lot of doctors/ medical personnel don't know this

NwaAmaikpe:


Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS'

Of course it is possible.

That 'AA' is married to an 'AS' does not mean that
the 'AS' can not shag another 'AS' on the side and bring in a bastard 'SS'

---

Please don't believe this nonsense... Very soon, one confused scientist will bring up a theory claiming it is possible for paternity tests to come back negative when you are truly the father.

darlenese:
nonsense and ingredient.


no AS and AA has ever given birth to an SS. carry your rubbish theory and gerrahere.



mshweeeeeeew.

tosyne2much:
So you go chase am comot?

sainty2k3:
Yea difficult, bit I'm happy I tried, I hope someone with deep knowledge of this will simplify it further

tosyne2much:
So many funny comments on this thread

See as guys dey para for the OP

lexy2014:
after this expert analysis what is ur expert advice 4 intending married couples and married who are still in d baby factory?

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

joyandfaith:
ur post, heading and explanation are misleading. see what you posted ' Re: Yes, It Is Not Impossible. 'AA' Can Marry 'AS' and give birth to SS'.
I repeat you are misleading public. accept this and apologize. in haemoglobinopathies, diagnosis is molecular ss is a diagnosis, as is another diagnosis. s beta thal is also diagnosis. if you say misdiagnosis, I can tell u clinically there are subtle difference between s beta thal and ss. that is why input of haematogist is very important to avoid misdiagnosis.

jnrremedy:
being a doctor doesn't mean u know everything pls go and update ur knowledge of hemoglobin defects or simply visit sickle cell center in igbobi Lagos.
and yes it is very very possible for a AA and AS couple to give birth to a sickler though not the SS sickler (but electrophoresis will read the genotype as SS)
a lot of doctors/ medical personnel don't know this

sainty2k3:
Please research more on it rather than discarding a fact Sbeta thalassemia are often misdiagnosed as SS and Abeta thallasemia are often misdiagnosed as AA on electrophoresis, google scholar is your friend,

tosyne2much:
So many funny comments on this thread

See as guys dey para for the OP

What is the Genotype and Blood Group compatibility that is good for marriage?

Study this table below carefully:
AA + AA = AA, AA, AA, AA
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SC, SC
AC + AC = AA, AC, AC, CC
Based on the table above, you can see that a person with the genotype AA can marry across. There’s no risk of having a sicklier for a child even when he or she marries an SS. An AA genotype person marrying an SS can only result in AS children. There’s no hope of having a child with the genotype AA. But there’s no danger either.
Someone with the genotype AS should only marry someone with the genotype AA because if AS marries another AS there’s one out of 4 chances (AS, AS, AA and SS) that they will have a child with the sickle-cell disease. Same applies when AC is combined. AC and AS combine will produce AA, AS, AC, SC, the sickle-cell disease will be SC.
Of course there are many cases where two abnormal was combined that is an AS and AS or AC and AC or AC and AS couples and had up to five or six children without a single sicklier among them. But there is no need to risk it? What if you’re not so lucky? Can you forgive yourself when you end up having a child with the sickle-cell disease and put the child through the agony the disease brings when you could have easily avoided it by doing a genotype and blood group compatibility test.

1StopRudeness:
You still dey ask..?? Na to chase am go her papa house sure pass

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

joyandfaith:
that is misdiagnosis. I repeat with good clinical history the misdiagnosis can be avoided in clinical practice. the heading is misleading. the heading could have been , "Medical laboratories in Nigeria can misdiagnose AA or AS as SS''

stevecantrell:
its not funny

its 100% scientific fact.

If youre getting married know your genotype, it might save you the cost of a DNA test in future.

funmisticqueen:
I have research on it, but you seem to be contradicting yourself, you are yet to show me SCIENTIFIC SOURCES supporting your claim. This is not evidence based and you are still stubbornly supporting something you can't even explain clearly.

sgtponzihater1:
I did a post on Nigerian doctors days ago, and for some sad reason, it was deleted and I was banned for 24hrs. Nigerian doctors can't see an unfamiliar topic and discuss at an academic level on it, they despise the unfamiliar and are quick to point out quackery. The OP have brought up an academic and post graduate level argument, which while possible invitro, is left with very few example invivo. Mutation as a phenomenon is however valid. Once again well done OP

sainty2k3:
YES it is not impossible, couples that are AA/AS can give birth to SS , this is how
1. let me differentiate between haemoglobin genotype and haemoglobin phenotype
To get a particular GENOTYPE you have to do a genetic testing or use two or more of the screening test (the conventional electrophoresis that we do + HPLC or other similar test) to confirm the true genotype while hb PHENOTYPE is the appearance /characteristics of an individual haemoglobin on conventional electrophoresis which we loosely refer to as GENOTYPE
Most times when we call ourselves AA,SS,AS we are actually referring to our Haemoglogin PHENOTYPE and NOT GENOTYPE, as most of us don’t do genetic tests, all we do is haemoglobin electrophoresis
2. lets explain the concept of thalasemic trait. Thalassemias are quantitative defect of haemoglobin which means some one can be AA but the one or both A in this person is is absent otherwise known as thalassemia minor and major respectively. If such person run haemoglobin Electrophoresis( the test that we always loosely regard to as genotype) only A band will be seen and such a person will be regarded as AA. But they are also prone to anaemias and some certain abnormal features in the blood depending on the degree in the reduction in the defective A . such individuals can be Aβ-Thalassaemia(otherwise known as thalassaemic trait) if one of the’ A gene’ is normal, or β-Thalassaemia major if both are affected
3. lets merge the two concepts above and form AND SEE THE DIFFERENT PHENOTYPE THAT EXIST AND THE POSSIBLE CORRESPONDING GENOTYPE
If PHENOTYPE is AA the likely GENOTYPES will be AA , Aβ-Thalassaemia
If PHENOTYPE is SS the likely GENOTYPES will be SS, Sβ-Thalassaemia (MEANING THE OTHER ‘A’ THAT WOULD HAVE MADE THIS AN ‘AS’ IS TOTALLY ABSENT) Others might include SD,SG etc though these are very rare
If PHENOTYPE is AS the likely GENOTYPES will be SA (NOTE – ‘S’ COMES BEFORE ‘A’ BECAUSE THE A IS THALASSAEMIC, THOUGH NOT TOTALLY ABSENT AS THE ONE ABOVE ,IT IS SUSBSTANTIALLY REDUCE), or truely AS
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. There possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

sainty2k3:
YES it is
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. there(sic) possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

tosyne2much:
Are you trying to say that a woman can bring a bastard child home for me to father?

Protein0:
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. there(sic) possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

According to u, partner 1 is actually Aβ-Thalassaemia (AA on electrophoresis). The β-Thalassaemia copy was read as A on electrophoresis.
Here is my question, why will scenario IV show SS, given that the thalassemic trait (that was read as A in d parent) be read as S in the child?
Thanks

sainty2k3:
Please what is not clear ?
Is that you are not aware the difference between genotype and phenotype
Or you don't know that HB electrophoresis done gives a phenotype which might not necessarily be the Genotype as it is less sensitive in picking quantitative defect of Globin gene known as thalassemia

You still not clear that someone that is Abeta thalassemia meaning he has one of the A deleted bit the other A is covering up ,such person appears AA on HB electrophoresis