Nedsnow:
Am so surprised am seeing so many people claiming to be medical practitioners arguing this OP article.
No wonder our ministry of health is dying. Most of you have refused to acquire more knowledge and make your own personal researches on them. All you ve been sticking to are all those old researches and beliefs.
OP! Am with you on this. I have seen the way you ve tried explaining to this people, but they wont just understand. But all of you should note this.
He never said the SS is the real SS sickler.

What most of you lack here is simple comprehension and understanding

Their I.Q's have been shortchanged. Some will still come and argue blindly. Consider them as a man who has no qualification in pharmacy and sells drugs in a small kiosk saying that he is versed in the science of drug prescription and administering than most qualified doctors and pharmacists

femi4:
That you are sickle cell doesn't mean you are informed

Raiders:
it seems like you like yellow WOMEN that are thick with big a5S

Bros I like yellow women but not too thick. If you get anyone you fit refer to me o make I hook up with it. I

I agree with the op 110%. Was so excited to see the topic believing that finally people will understand that if an 'ss' child is born to a couple with as and aa, it won't readily be assumed to be infidelity. You can imagine my surprise and disappointment from 'colleagues' who failed to understand this basic concept.


Note: Apologies to the mod but in order to help spread the word, I have taken it upon myself to mention and reply to as much people as I can individually why this is possible in our environment. This is just too important t to ignore. Lives and marriages gave been destroyed in the past and I am only trying to ameliorate that.

Thanks for your understanding.

nelszx:

Yes those are simple medical terminologies that only those in the line will understand with ease. Though some point raises eyebrow but still on still until proven otherwise it's educative.

N.B: The op MIGHT be right but one thing stands, this phenomenon can never happen in Nigeria as "Thalassemia trait" can't be found this is part of the world rather what we have is HbS and HbC the reason we have sickle cell disorders on the high side (HbSS and HbSC). The reason I said it raises eyebrow

maybe 4u and a few folks with medical background. d write up ought 2b in a medical journal not NL where it can b well critiqued by people in d field like u just u doing. 4me, i don't think any info has been passed across

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

NwaAmaikpe:


Yes, It Is Not Impossible. 'AA' Can Marry 'AS' And Give Birth To 'SS'

Of course it is possible.

That 'AA' is married to an 'AS' does not mean that
the 'AS' can not shag another 'AS' on the side and bring in a bastard 'SS'

---

Please don't believe this nonsense... Very soon, one confused scientist will bring up a theory claiming it is possible for paternity tests to come back negative when you are truly the father.

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

anyebedgreat:
No way. This is how we know it and this is how it works.
AA + AA = AA, AA, AA, AA
AA + AS = AA, AS, AA, AS
AA + SS = AS, AS, AS, AS
AA + AC = AA, AA, AA, AC
AS + AS = AA, AS, AS, SS
AS + SS = AS, SS, SS, SS
AS + AC = AA, AC, AS,SS
SS + SS = SS, SS, SS, SS
AC + SS = AS, AS, SS, SS
AC + AC = AA, AC, AC, SS

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

Vetsolo:
wrong conclusion AA /AS CAN NEVER GIVE SS

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

jtjohn:
It is not possible........

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

sgtponzihater1:


Mumbo jumbo, Mendelian inheritance doesn't support AA and AS having SS, no explanation can justify it.

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

LionDeLeo:
OP, I did not bother to read your analysis because I know you just want to make noise.

What you are saying is the most impossible thing on Earth.

Even AA & SS cannot produce SS, not to talk of AA & AS.

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

zeetyzin:
Am I the only one who doesn't understand all this??.

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

Piiko:
I am AS and I hope the love of my life is AA I only want 1 kid, I don't want a Sickler God abeg give me AA wife

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

oviejnr:
The only reason where AA can marry AS and give birth to SS is when the child doesn't belong to the man. You don't need a DNA to find out, send that hoe outta your house

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

Danelo:
OP scientifically it is impossible for AA and AS to produce SS please don't mislead us

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

sod09:
don't mind the op
He's saying total rubbish

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

sainty2k3:

Thank you, to be really sure of the genotype, [b]you need to do genetic studies, [/b]but since that's not widely available, You can do both [b]HB electrophoresis and High performance Liquid Chromatography (HPLC) t[/b]here two we help in proper interpretation

genetic studies ke?here we go again...so much grammar without information.kudos 4 ur attempt 2 inform d public but ur write up ought 2b in a medical journal not on NL. cos what ought 2b 4 general info u laced with 2much technical jargon that those outside d field wouldnt understand.its like trying 2 explain d contents of a drug 2a patient. who has time 4 pharmacological grammar?its not necessary. what a doctor does is after telling a patient his/her problem in d simplest English, he gives a solution and this u didn't do

alizma:
Make I hear say somebory carry bele in my name come born the pickin with another genotype we no relate to my own then we go do this your calculation, possibly for hospital as for now, this calculation Na LAWMA property.

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

hardeycute:
I don't think NL mods make their own research before pushing post to FP.

Later we would have a disclaimer .

One of the reasons I want professionals not old members

Seun don't you pay them ??

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

1StopRudeness:
Yeye genetic probability calculations/posibilities....even If all ur village witch get time reason ur matter....AA & AS can't give SS...

It can never happen...make no woman try this yeye with me oooo...me na confirm AA...if I marry any AS babe wey wan come pull this SS stunt genetic calculation use explain herself out of infidelity.....just dey go ur papa house..no need to explain this nonsense genetics to me

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

Welcomme:
Is it only me that don't understand what the jargons this op wrote? U just wan show urself.

To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

AlphaT1:


OP is misleading the public with false information and you are supporting it.....why?

Na na na, never supported him na. If you read my submission I made it clear that thalasaemia and HbSS are two different disease entities even though they are both forms of SCD and the way to diagnose them are different as well.

But if you look at what the Op said about the SS determined by electrophoresis, I think he made it clear it was not the real SS and that was why I brought the issue of quantitative analysis, because someone may be labelled SS not knowing that there may be a missing Hb chain.

And I also think the Op's topic is misleading.

Thanks thanks thanks my brother

Ayam not understanding!

peacettw:


To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

pls wat is AC, I live with nurse Nd a qualified doctor
None of them ever mention AC as genotype,we shd stop misleading pple with wrong info it's bad pls

Oga Op your title is misleading ooo, there can be misdiagnosis of S B- thalasaemia showing as SS yes we accept but advanced screening will be able to differentiate the two.

Its quite dangerous for you to just come and say AA plus AS can give you SS, do you know the panic it can cause for people who don't even have an idea of what you are talking about and all they know is AA , As can marry.

I just don't understand how people post things these days, this is Nairaland not medic- land. Your audience should determine how you post. How many peeps even understand what you are saying, now its on FP.

You should have said SB- thallesaemia can be misdiagnosed as SS in Nigeria and there will be a healthy discussion about that and everybody will understand.

Besides thallesemias are not so common over here.

sod09:
pls wat is AC, I live with nurse Nd a qualified doctor
None of them ever mention AC as genotype,we shd stop misleading pple with wrong info it's bad pls

You should try Google then. You will be amazed the things I've found on my own on that platform. We simply can't know it all dear

kenny5811:
mtcheeeeew... AA - AS = SS.... wer d 2nd S cum from?

lebienconnu:
The HbS heamoglobin is as a result of a point mutation on the chromosome 16 which codes for the beta chain of the haemoglobin. Blood phenotype SS can only ensue if the foetus inherits mutated chr 11 from both parents (homozygotic).

Now, AA vs AS shows that only one of the couple has defective chr 11. It is, therefore, scientifically impossible for AA vs AS to produce SS offspring.

if the mother's ova duplicates before fertilization and later fuses with the sperm cell an abnormal zygote will form leading to complete hydatidiform mole (69 Bleep or 69XXY), an abnormal pregnancy which definitely autoaborts.

This piece of shit is defying the well proven theory of evolution. This is a very shameful article and I am very angry that it made Nairaland first page taking into cognition the position of this forum in the global media. I am also upset and embittered that this trash was written by a Nigerian.

Thanks my brother.. This people sha want make we get hypertension

peacettw:
I agree with the op 110%. Was so excited to see the topic believing that finally people will understand that if an 'ss' child is born to a couple with as and aa, it won't readily be assumed to be infidelity. You can imagine my surprise and disappointment from 'colleagues' who failed to understand this basic concept.


Note: Apologies to the mod but in order to help spread the word, I have taken it upon myself to mention and reply to as much people as I can individually why this is possible in our environment. This is just too important t to ignore. Lives and marriages gave been destroyed in the past and I am only trying to ameliorate that.

Thanks for your understanding.

You are doing a great Job. Thank you . many Nigerians ,some Doctors inclusive are too lazy to research those fact, they rather come here and say it is not possible.

peacettw:


To help explain further, our people wrongly believe that its only ss that is Sickle cell disease. In truth, there are many 'combinations' like SC, SB-thal, SD punjab etc. (notice they all have one thing in common, at least one S in the combination)

Now let's put our heads together, how do you think people get these other types? ....
Ans: exactly the same way you get the ss.

So, if you are AS and get married to AC, AB-thal, or Ad punjab, u stand a risk of getting a child with Sickle cell disease. It's that simple.

Another question... How many of our labs here in Nigeria do you think can correctly detect AC, AB-thal, or Ad punjab?
Ans: Basically a few. I saw my first SC in a px 2 years ago in a 17 year old who was told her whole life that she was AS.
Most labs can't pick up the C, b thal or d punjab, once they see an A with no S, they automatically assume it to be AA but in truth might actually be AC, AB-thal, or Ad punjab.

In essence, it is possible for 'AA' (wc we know might actually be AC, AB-thal, or Ad punjab) to get married to AS and give birth to SC, SB-thal, SD punjab.. (wc again our labs will incorrectly call SS since they lack the proper equip to detect the C, b thal or d punjab.


I hope I have sufficiently cleared the air. Now, please go and spread the word and stop castigating that poor innocent woman.

Wow.. Enlightening...
Never knew we had any like b thal and d punjab..
Thanks a lot for this...
Learnt smtn new today.