₦airaland Forum

noxide:
sainty2k3, I could not go through all 11 pages of this thread but I know have been reminded that an AA and AS couple can NEVER have an SS offspring.

It is IMPOSSIBLE

Your analogy of thalassemias where the β-thal coexists with the A gene is flawed because the patient's genotype is now Aβ, not AA as you erroneously stated

A laboratory could record AA as the genotype, but the patient is actually Aβ. as such an Aβ and AS couple can NEVER have an SS offspring.

Exclude clerical errors from the laboratory, that's the source of confusion

Ghokes:
Op you have to check your stuffs over again and again.
There is a difference between Sickle Cell Disease(common in Sub-Saharan Africa) and Thalassemias(commonly seen in the Mediterranean region including Spain, Portugal, Italy etc).
The former has to do with substitution of amino acids while the later has missing amino acids.
In fact, from the basic integrated science of JSS 2 couple with AA and AS can never have SS offspring.
Go back and dust your book over again and again.

peacettw:
I agree with the op 110%. Was so excited to see the topic believing that finally people will understand that if an 'ss' child is born to a couple with as and aa, it won't readily be assumed to be infidelity. You can imagine my surprise and disappointment from 'colleagues' who failed to understand this basic concept.


Note: Apologies to the mod but in order to help spread the word, I have taken it upon myself to mention and reply to as much people as I can individually why this is possible in our environment. This is just too important t to ignore. Lives and marriages gave been destroyed in the past and I am only trying to ameliorate that.

Thanks for your understanding.

jnrremedy:
thanks op for bringing this up this night
am sure a lot of people have learnt even the ignorant hematologist ( he just can't shamefully agree publicly after arguing blindly)
Good night

lisbonabdulahi:
hmmmm, that will be a good read . when is he completing the work.? Hope you keep us updated

lisbonabdulahi:
in medicine, common aikement are common. Did you read the history of the woman?. The truth is dat, theoretically it can happen, but I have never seen a case in practice

Chi59:
Not always

@op, great job. Very educative

naijaking1:
If the glutamic acid mutates to valine, we have Beta-s, or HbS.
Mutation to lysine gives rise to thalassamia

naijaking1:
The site is ok for patient education, it is too basic and simplistic for physicians and serious scientist. It might be a good idea for you to make an appointment with your doctor for better explanation of this topic. It's better to look at the whole elephant, and not just the trunk, ears, or nose in isolation. You have to understand the big picture.

naijaking1:
Ok, once again, the difference is valine and lysine.
If you don't know already, the genetic pair of the beta globulin chain of the hemoglobin is mutated, and they transcribe these amino acids instead of glutamic acid. Presence of valine or lysine changes the PH and pk values of the new hemoglobin solution so they sickle and deform in shape-a condition that makes the spleen pit them out of the circulation with resulting anemia, vaso-occlussive conditions, etc.
The electrophoresis picks up the transcribed elements, while gene splicing is what you need to make the diagnosis at the sequencing level.

joyandfaith:
the professor will deny u. u did not understand what professor said.

joyandfaith:
which fact? I do not ur info. if you want 20 journals on misdiagnosis in hemoglobin testing, I shall provide the links. it is ur annoying argument that take us here. initially, you were told that information is misleading but u refused to listen.

nelszx:
Thalassemia wouldn't show anything (A or SS) on Hb electrophoresis. You might see HbH (Barts Haemoglobin) but definitely not A band or SS , it's best diagnosed using CBC (HB and the RBC indices) with Ferritin level

naijaking1:
If you electrophorese valine and lysine will they come out the same? If you correctly answered no, then there is no way a good technologist will come to my office to tell me that the B-thal and Beta or alpha-thal are now migrating to the same spot on the plate. Unless your reagents are bad.
And, I think this is where you got confused. The two hemoglobinopathies don't have the same electrophoretic pattern in a good lab! So that patient you had classified as AA, or AS might have been wrong in the first place.

funmisticqueen:
5 consultants of which 3 are professors, eight senior registrars, need i say more, i would have asked them but maybe during the week.

joyandfaith:
so are looking for analyzer because you did not understand d journal.understand textbook first before you read journal.

Syphonn:
can u help us cross it so we can see where the ss comes from when on parent is AA, ITS UNBELIEVABLE

joyandfaith:
ur topic is wrong.

innosaint27:



It is important we disseminate info with valid facts especially on sensitive topics like this.

Hb electrophoresis remains the conventional diagnostic investigation for genotyping all over the world.

There are other advanced techniques like PCR and Isoelectric focusing for confirm genotypes but these investigations are very expensive & most hospitals including tertiary health facilities don't have them.

The thalassamias are known to rarely occur in the black population. The prevalence is very low.


I accepted the OP to tell us, what Thalassamias are, how they are inherited, diagnosis, clinical presentation of patients, laboratory findings in such patients etc. And not confuse the public by telling us it is possible for AA + AS = SS.

That is a fallacy & a scientific blunder!

jnrremedy:
I never said anywhere that AS and SS will produce SS u now that
pls read all my post and point to where I said that.
that is one thing I don't like about doctors ( i have a lot of them as freinds) they believe they know it all that nobody can know more than them

joyandfaith:
Tell Dr Abiessuku of Chemical pathology you have poor knowledge of hemoglobininopathies. Tell Dr Osho P.O that you were sleeping in class during lectures. Partial knowledge is your problem. Pls, do not say AA and AS can produce SS in any conference. if you do, u get know in ur head. so, if chromatographymedical or pcr is used, AA and AS will still produce SS. nonsense.

joyandfaith:
because op thinks he is talking to health workers or medical researchers. many people here cannot analyze it logically. we could have helped him to analyze if topic is changed.

AmbFitsaint:
Na you oo
Even consulatant haemotogist no sabi these stiffs wey u just move

CanadianNurse:
OP your heading/title is wrong

Genotype AAv can never form SS when combined with AS

TThat people do the mistake of interchanging their phenotype or Genotype doesn't make it possible for AA +As to give sS


If my Genotype is AA I can even marry an SS..with little or no chance of producing SS

donhils:
When articles/information like this come up, it is expected we see a [/b]credible[b] source because some people might swallow everything here hook, line and sinker.

SAVEDBABA:
Quite educative though, but based on your write up.... the child is not actually SS but SB,but everybody took it as SS.Educative though.

Scholar212:
OP can you cite any medical journal to buttress your claim, in all my haematology classes and even deep lectures on blood grouping, genotype and haemoglobinopathies I have never come across such not online, textbook or lecture. The burden of prove now lies on you to justify your claim of co-dominant thalasemia trait and HB genotype

funmisticqueen:
Nobody with knowledge has actually agreed with your theory not to talk of simplifying it

edeXede:


Op, let me help me simplify it

In summary, it is not possible under correct diagnosis for AA and AS to produce SS

except

AA was misdiagnosed, meaning he is actually AS but was misdiagnosed as AA.

---

Dont come here and be telling us 1+1=1
Na lie. 1+1=2

SAVEDBABA:
Op......i think i grab your point.....it is not possible for AA And AS couple to give birth to SS but SB but usually most lab will just tell you SS because of testing they use,am i correct.

Saint83:
Hahahaha Op,its obvious that you a native doctor because if you are a medical doctor, you won't post this impossible calculation.... AA/AS can't n produce SS.

Anyways thanks for wasting time