₦airaland Forum

lisbonabdulahi:
what is the chance of this happening, and when last did we see one

lebienconnu:
The HbS heamoglobin is as a result of a point mutation on the chromosome 16 which codes for the beta chain of the haemoglobin. Blood phenotype SS can only ensue if the foetus inherits mutated chr 16 from both parents (homozygotic).

Now, AA vs AS shows that only one of the couple has defective chr 16. It is, therefore, scientifically impossible for AA vs AS to produce SS offspring.

if the mother's ova duplicates before fertilization and later fuses with the sperm cell an abnormal zygote will form leading to complete hydatidiform mole (69 Bleep or 69XXY), an abnormal pregnancy which will definitely abort.

This piece of shit is defying the well proven theory of evolution. This is a very shameful article and I am very angry that it made Nairaland first page taking into cognition the position of this forum in the global media. I am also upset and embittered that this trash was written by a Nigerian.

Protein0:

Check jnrremedy's answer

innosaint27:



Oga I use God beg you, never in your life should you again classify Hb Genotype AS as a type of sickle cell disease (SCD). You and the textbook you copied from are totally wrong.


Individuals with HB genotype AS are normal in all sense with those who are AA except that they posses sickle cell trait. This means that, if they get married to another individual who is heterozygote (AS or SC or AC) for the sickle cell trait or homozygote (SS), they stand the risk of producing offsprings with sickle cell disease (SS or SC).

Pls, I repeat those with genotype AS are 100% NORMAL. THEY ARE NOT SICKLERS. THEY ONLY CARRY THE SICKLE CELL TRAIT.

As for the thalasaemias, their prevalence is extremely low in people of African descents. So, what we ought to be bothered about is SICKLE CELL ANAEMIA (HBSS/HBSC)

Protein0:
To sign out, what will beta thalassemia major read on electrophoresis?

Protein0:
U r not getting my question.
Was it not d thalassemic trait inherited from partner 1?
It was read as A in d parent, right?
Why as S in d offspring?

Modified, d genotype is Sbeta thalassemia in d child just as partner 1's genotype is Abeta thalassemia.

joyandfaith:
doctors are right because AA and AS cannot produce SS. if it happens doctors know something is missing or wrong.

chalondk:
Oga you are funny oo.. you mean to tell me if i go a hispital to check for my genotype they would start checking something else and tell me tjat is a my genotype abi??

You are twisting the conversation to say someones genotype is AA but his phenotype is something else.. like that is the talk.

CAN PARTNERS OF GENOTYPE AA AND AS GIVE BIRTH TO AN SS CHILD

Protein0:
4. Lets assume this our hypothetical couple have Hb eleterophoresis done and was told that the genotype of partner 1 is AA, and that of partner 2 is AS ,but the one that is called AA is actually Aβ-Thalassaemia as ealier mentioned. there(sic) possible offspring include
I. AA, If the child inherit the normal A from partner 1 and another normal A from partner 2
II. Aβ-Thalassaemia ,If the child inherit β-Thalassaemic A from the partner 1 and normal A from partner 2
III. AS,If the child inherit normal A from partner 1 and S from patner 2
IV. Sβ-Thalassaemia If the child inherit β-Thalassaemic A from partner 1 and S from partner 2
Note that scenario I above will show AA on Hb electrophoresis, scenario ii will show AA on electrophoresis, scenario iii will show AS on electrophoresis and scenario iv will show SS on electrophoresis
I have tried to simplify the medical terms but if you still have a doubt or clarification ask and I will try to shed more light, as much as I can.

According to u, partner 1 is actually Aβ-Thalassaemia (AA on electrophoresis). The β-Thalassaemia copy was read as A on electrophoresis.
Here is my question, why will scenario IV show SS, given that the thalassemic trait (that was read as A in d parent) be read as S in the child?
Thanks

funmisticqueen:
I have research on it, but you seem to be contradicting yourself, you are yet to show me SCIENTIFIC SOURCES supporting your claim. This is not evidence based and you are still stubbornly supporting something you can't even explain clearly.

lexy2014:
after this expert analysis what is ur expert advice 4 intending married couples and married who are still in d baby factory?

jnrremedy:
being a doctor doesn't mean u know everything pls go and update ur knowledge of hemoglobin defects or simply visit sickle cell center in igbobi Lagos.
and yes it is very very possible for a AA and AS couple to give birth to a sickler though not the SS sickler (but electrophoresis will read the genotype as SS)
a lot of doctors/ medical personnel don't know this

naijaking1:
Classic Sickle cell disease denoted by AS and SS are different and must be differentiated from Thalassemia major and minor.
Sickle cell:
1. Mostly among African and African American
2. Genetic abnormality is substitution of glutamic acid for valine at the 6th beta position
3. Clinical presentations maybe similar, but doesn't have the variations of Thalassamia

Thalassamia:
1. Mostly among people of Mediterranean descent
2. Genetic substitution of glutamic acid for lysine, not valine as in SCD
3. Wide clinic presentations from the instantly fatal absence of both alpha and beta chains of hemoglobin, to mild abnormality of the beta chain at the same 6th position.

This understanding is importance for both medical lab technologists who perform these tests, the nurses who counsel the patients, and the physician in charge of diagnosing and managing these conditions.
They don't test the same on electrophoresis, because their amino acid components are not similar, therefore if your lab has been identifyoing thalassamia in terms of AS, SS, then that is wrong

joyandfaith:
op and many here could not understand import of the journal. op is dangerous. hope he is not a doctor sir. if he is mls, I can only pray for people that he would meet. if he is a nurse, no problem, we are still save. if he's not any of above health worker ,ur sin of misinformation is forgiven.

funmisticqueen:
If you tried, you didnt suceed, even i had a hard time comprehending it, i had to read it twice to get it which was strange for me.

joyandfaith:
op u do not understand the journal at al. besides, the journal there are more information in postgraduate haematology textbook.if you an haematogist or resident in haematology you will know the book. in some, there could be disorder of hemoglobin structure and number which could produce sickle cell and thalassemias respectively. thalassemias is a bad disorder because one or more hemoglobin chains are missing. it is not possible with aa and as to produce ss.pls do not create confusion people. thanks.

funmisticqueen:
You just quoted only one study and the study you quoted actually collaborates with what fitnessdoctor said, it doesnt say AA and AS can give birth to SS as you claim.
Please stop misinforming people, always show refrences and more than one please.

beamtopola:
Pls stop misleading Nigeria, there is no research done on this by usa : a black man can't get it right. It is never possible and its impossible for AA and AS to give birth to SS, nairaland shold stop promoting nonsence. The only phenotype we carry out its ABO where by their is dorminant and hiding gene. Here A+ and B+ can give birth to O. Pls genotype is genotype, and stop misleading Nigeria.

darlenese:
I think those people who have experienced this should go for a DNA test, instead of assuming the possibility a theory that has not be propounded by anybody. this assumption isn't correct if it has not be proven, and it shouldn't even be brought to front page in the first place.

sgtponzihater1:
While I know where u are driving at. The above explanation will give HBSthal, which is different from HBSS. The former have less sickling events and can lead nearly normal lives with very few crises. But Only mutation would cause AA that married AS to give birth to SS, such phenomenon, while feasible theoretically have never been documented. Weldone anyways.

funmisticqueen:
Please quote your refrences for all this information.

darlenese:
nonsense and ingredient.


no AS and AA has ever given birth to an SS. carry your rubbish theory and gerrahere.



mshweeeeeeew.

Crixina:
Dear Op, as much as you are trying to be educative...you lost most of us...A post like this should be brought to a layman's understand, the use of some terms there are rather too vague most people's comprehension.

sgtponzihater1:
Mumbo jumbo, Mendelian inheritance doesn't support AA and AS having SS, no explanation can justify it.

nelszx:
Quite educative

dreshemokha:
Op. Genetics and health is not mathematics as you just calculated.
And yes it is totally IMPOSSIBLE, a marriage between AA and AS can NEVER produce SS.
Moreover, there is no relationship in inheritance between sickle cell diseases and thalassemias.


Am a doctor with a health blog. Check my signature and visit my blog for robust health info and publications.

ChelseaDr:
Op thanks for this because a lot of people may not know this.

It is also important to note that although Sβ-Thalasaemia and Hb SS are both forms of Sickle cell disease, they are completely two different disease conditions with far-reaching impact on the person suffering from them.

While Hb SS is as a result of defect in the quality of haemoglobin, Sβ-thalasaemia is as a result of the quantity of haemoglobins present and to diagnose this one needs quantitative analysis of the haemoglobin chains whereas qualitative analysis is enough to diagnose SS which electrophoresis does.

Again, thank you.
Cheers!!