Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE
(resembling acute viral hepatitis)
acetaminophen, salicylates (doses over 2 grams daily)

Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE
(resembling acute viral hepatitis)
acebutolol, indomethacin, phenylbutazone, allopurinol, isoniazid, phenytoin, atenolol, ketoconazole, piroxicam, carbamazepine, labetalol, probenecid, cimetidine, maprotiline, pyrazinamide, dantrolen, metoprolol,quinidine, diclofenac mianserin quinine diltiazem naproxenranitidine enflurane para-aminosalicylic acid sulfonamides ethambutol penicillins sulindac ethionamide phenelzine tricyclic antidepressants halothane phenindione valproic acid ibuprofen phenobarbital verapamil

Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER
adrenocortical steroids phenothiazines sulfonamides antithyroid drugs phenytoin tetracyclines isoniazid salicylatesvalproic acid methotrexate

Drugs that may cause CHOLESTATIC JAUNDICE
actinomycin D chlorpropamide erythromycin amoxicillin/clavulanate cloxacillin flecainide azathioprine cyclophosphamide flurazepamcaptopril cyclosporine flutamide carbamazepine danazol glyburide carbimazole diazepam gold cephalosporins disopyramide griseofulvinchlordiazepoxide enalapril enalapril haloperidol ketoconazole norethandrolone sulfonamides mercaptopurine oral contraceptives tamoxifen methyltestosterone oxacillin thiabendazole nifedipine penicillamine tolbutamide nitrofurantoin phenothiazines tricyclic antidepressants nonsteroidal phenytointroleandomycin anti-inflammatory drugs propoxyphene verapamil

Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)
allopurinol gold phenytoin
aspirin hydralazine procainamide carbamazepine isoniazid quinidine
chlorpromazine isoniazid quinidine chlorpromazine nitrofurantoinsulfonamides diltiazem penicillin tolbutamide disopyramide phenylbutazone

Drugs that may cause CHRONIC LIVER DISEASE

Drugs that may cause active chronic hepatitis
acetaminophen (chronic use, large doses) dantrolene methyldopa isoniazid nitrofurantoin

Drugs that may cause liver cirrhosis or fibrosis (scarring)
methotrexate
terbinafine HCI (Lamisil, Sporanox)
nicotinic acid

Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis)
chlorpromazine/valproic acid (combination) imipramine thiabendazole phenothiazines tolbutamide chlorpropamide/erythro-mycin (combination) phenytoin

Drugs that may cause LIVER TUMORS (benign and malignant)
anabolic steroids oral contraceptives thorotrast danazol testosterone

Drugs that may cause DAMAGE TO LIVER BLOOD VESSELS
adriamycin dacarbazine thioquanine anabolic steroids mercaptopurine vincristine azathioprine methotrexate vitamin A (excessive doses) carmustine mitomycin cyclophosphamide/cyclo-sporine (combination) oral contraceptives

http://hepcnet.net/drugsandliverdamage.html

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