http://www.cnn.com/2014/08/04/health/experimental-ebola-serum/index.html?sr=fb080414ebolaserum1030aStoryLink

Secret serum likely saved Ebola patients
By Dr. Sanjay Gupta and Danielle Dellorto, CNN
updated 10:38 AM EDT, Mon August 4, 2014

Source: CNN
STORY HIGHLIGHTS

Dr. Kent Brantly and Nancy Writebol received experimental drug ZMapp
ZMapp had only been tested in monkeys
Brantly was given the drug after his condition deteriorated
Within an hour, source says his symptoms were nearly reversed[b]

(CNN) -- Three top secret, experimental vials stored at subzero temperatures were flown into Liberia last week in a last-ditch effort to save two American missionary workers who had contracted Ebola, according to a source familiar with details of the treatment.
[/b]On July 22, Dr. Kent Brantly woke up feeling feverish. Fearing the worst, Brantly immediately isolated himself. Nancy Writebol's symptoms started three days later. A rapid field blood test confirmed the infection in both of them after they had become ill with fever, vomiting and diarrhea.

It's believed both Brantly and Writebol, who worked with the aid organization Samaritan's Purse, contracted Ebola from another health care worker at their hospital in Liberia, although the official Centers for Disease Control and Prevention case investigation has yet to be released.
A representative from the National Institutes of Health contacted Samaritan's Purse in Liberia and offered the experimental treatment, known as ZMapp, for the two patients, according to the source.

The drug was developed by the biotech firm Mapp Biopharmaceutical Inc. The patients were told that this treatment had never been tried before in a human being but had shown promise in small experiments with monkeys.

Second Ebola patient heading to U.S. Doctors struggle to treat Ebola patients Ebola transport team speaks to CNN First American Ebola patient comes home
According to company documents, four monkeys infected with Ebola survived after being given the therapy within 24 hours after infection. Two of four additional monkeys that started therapy within 48 hours after infection also survived. One monkey that was not treated died within five days of exposure to the virus.

Brantly and Writebol were aware of the risk of taking a new, little understood treatment; informed consent was obtained from both Americans, according to two sources familiar with the care of the missionary workers. In the monkeys, the experimental serum had been given within 48 hours of infection. Brantly didn't receive it until he'd been sick for nine days.
The medicine is a three-mouse monoclonal antibody, meaning that mice were exposed to fragments of the Ebola virus and then the antibodies generated within the mice's blood were harvested to create the medicine. It works by preventing the virus from entering and infecting new cells.
The Ebola virus causes viral hemorrhagic fever, which refers to a group of viruses that affect multiple organ systems in the body and are often accompanied by bleeding.

Early symptoms include sudden onset of fever, weakness, muscle pain, headaches and a sore throat. They later progress to vomiting, diarrhea, impaired kidney and liver function -- and sometimes internal and external bleeding.
The ZMapp vials reached the hospital in Liberia where Brantly and Writebol were being treated Thursday morning. Doctors were instructed to allow the vials to thaw naturally without any additional heat. It was expected that it would be eight to 10 hours before the medicine could be given, according to a source familiar with the process.

Brantly asked that Writebol be given the first dose because he was younger and he thought he had a better chance of fighting it, and she agreed. However, as the first vial was still thawing, Brantly's condition took a sudden turn for the worse.
Brantly began to deteriorate and developed labored breathing. He told his doctors, "I am going to die," according to a source with firsthand knowledge of the situation.
Knowing his dose was still frozen, Brantly asked if he could have Writebol's now-thawed medication. It was brought to his room and administered through an IV. Within an hour of receiving the medication, Brantly's condition was nearly reversed. His breathing improved; the rash over his trunk faded away. One of his doctors described the events as "miraculous."
By the next morning, Brantly was able to take a shower on his own before getting on a specially designed Gulfstream air ambulance jet to be evacuated to the United States.
Writebol also received a vial of the medication. Her response was not as remarkable, according to sources familiar with the treatment. However, doctors on Sunday administered Writebol a second dose of the medication, which resulted in significant improvement.
She was stable enough to be evacuated back to the United States and is expected to arrive before noon Tuesday.
ZMapp has not been approved for human use, and has not even gone through the clinical trial process, which is standard to prove the safety and efficacy of a medication. The process by which the medication was made available to Brantly and Writebol is highly unusual. It may have fallen under the U.S. Food and Drug Administration's "compassionate use" regulation, which allows access to investigational drugs outside clinical trials.
Getting approval for compassionate use is often long and laborious, but in the case of Brantly and Writebol, they received the medication within seven to 10 days of their exposure to the Ebola virus.
On July 30, the Defense Threat Reduction Agency, an arm of the military responsible for any chemical, biological, radiological, nuclear and high-yield explosive threats, allotted additional funding to MAPP Biopharmaceutical due to "promising results."

Good. I knew cure would surface..

We thank God for science

Hope they ship it down to Nigeria ASAP

Praiseeeeeee the Lord! Please they should send it fast to west Africa.

Thank God.

This should be on the front page

Oh well..










License to continue eating Bush-meat..








I'm kidding..











I had never stopped..

It's not going to get Africa fast enough, money is not coming through for widespread distribution (big pharma is a cashcow, they don't make drugs for the poor) . The US will take care that they have enough vials before additional shipping out to countries who will have to source for financial aid to pay for it.

I read it before that they have somethink what they have testet at monkeys.

The problem is that not always when it works on monkeys it works the same way on human.

It is always a high risk to get medicine which come out without testing before in an hospital.

I hope they can make more very fast!!!!!!!!!!!!!!!!!!!!

Normaly clinical test needs some years before medicine will be given to people outside a clinical trial!!! it takes between 5 and 10 years normaly.

nora544: I read it before that they have somethink what they have testet at monkeys.

The problem is that not always when it works on monkeys it works the same way on human.

It is always a high risk to get medicine which come out without testing before in an hospital.

I hope they can make more very fast!!!!!!!!!!!!!!!!!!!!

Normaly clinical test needs some years before medicine will be given to people outside a clinical trial!!! it takes between 5 and 10 years normaly.

Then human subjects showed "significant" improvement after the serum was administered. We will know if the cure works in a few days time. The only reason they were flown back to US is because the cure seems to be working. If not, US govt would have left them back in Africa.

good

pDude:

Then human subjects showed "significant" improvement after the serum was administered. We will know if the cure works in a few days time. The only reason they were flown back to US is because the cure seems to be working. If not, US govt would have left them back in Africa.

you might be right.

To get drug which is not approved you always will have a risk.

I know about this risk when my husband had cancer and they put him on a new chemotherapy (the doctors ask us before if we want to make it) which they start to test on the first skin cancer patient, when we start we know we will have a 50:50 chance for my husband it was to late but for others it was the way to get a new life.

So we have to wait what comes!!!!!!!!!!!!!!!!!!!

When there is a strong WILL, there is always a way. I am sure now that some westerners are getting affected, this will finally be dealt with.

arsetalks: When there is a strong WILL, there is always a way. I am sure now that some westerners are getting affected, this will finally be dealt with.

Exactly. When the thing was killing Africans, US didn't give a fvck. But when it affected 2 of their guys, they suddenly came out with a serum. Na wa o

There is hope!
They should be fast about it abeg oh, bring it down to Africa before we die finish

arsetalks: When there is a strong WILL, there is always a way. I am sure now that some westerners are getting affected, this will finally be dealt with.

Sorry that is not tru!!!!!!

Do you know that also many westerners died of ebola when it starts in Congo!!!!!!!!!

When the two take this new medicine than they know it can help that is all!!!!!!!!!!!!!!!!!

The risk is always big!!!!!!!!!!!!!!!!!

Hope the cure is real and can be fast tracked.

What I found out of the two americans both belong to the organiation of Samaritan's purse and the head of this organisation is Franklin Graham the son of one of the richest pastors in America Billy Graham, perhaps he give money to this company, when they can heal both of them.

Why this company didnot make anything to the other doctor who was from Siera Leone, and who died some days ago on Ebola.

Samaritan's purse working under the umbrella to help but what they make more is to preach the gospel, why they take most of their workers out of Liberia because doctors without border didnot make the same and they will bring more doctors and healthworkers to West africa.

The organization's medical mission in Liberia, West Africa, is one of only two medical NGO's active in Liberia. Samaritan's Purse and SIM USA both have been actively engaged in treating the recent outbreak of Ebola hemorrhagic fever in Liberia. On August 1, 2014, the organization announced that it was evacuating 60 nonessential personnel from Liberia, it is noted that these evacuees are not infected with the ebola virus. Dr. Kent Brantly, a Texas based doctor working for Samaritian's Purse, the first of two American medical workers infected with Ebola in Liberia while treating the disease, arrived in the United States on Saturday, and is now being treated in a special isolation unit of Emory University Hospital in Atlanta, Georgia

In March 2001,The New York Times reported that Samaritan's Purse had "blurred the line between church and state", in the way it had distributed publicly funded aid to victims of the El Salvador earthquake. Residents from several villages stated they first had to sit through a half hour prayer meeting before receiving assistance

Remember Pfizer in Kano? If the drug was used on Africans and the result was not good we would be shouting that they used us as guinea pigs and sue them. The Americans were prepared to take the risk and signed consent forms and they were lucky it worked now we say it's a conspiracy.

Good
Thank God for science

pDude:

Exactly. When the thing was killing Africans, US didn't give a fvck. But when it affected 2 of their guys, they suddenly came out with a serum. Na wa o

True but I don't really blame them...Everyman dey on his own oo
How did Nigeria help other African countries when the disease was wrecking them and hadn't entered Nigeria?

Wasn't it when the disease entered Nigeria that Nigerians/doctors started testing kola nut etc for possible cure and also sent out precautionary measures??

Everyman should learn to help himself and depend less on other people....
It's not even like the whites are more intelligent than us, just that corruption has eaten deep into us.

MarvellousGod: True but I don't really blame them...Everyman dey on his own oo
How did Nigeria help other African countries when the disease was wrecking them and hadn't entered Nigeria?

Wasn't it when the disease entered Nigeria that Nigerians/doctors started testing kola nut etc for possible cure and also sent out precautionary measures??

Everyman should learn to help himself and depend less on other people....
It's not even like the whites are more intelligent than us, just that corruption has eaten deep into us.

and what is with the pastors who tell their followers that they can heal every disease, because the people have only to pray.
Is this not also a problem when Pastors claim (who where before University lecturer) so the people fell no need to start to search because praying and fasting will help to cure every disease!!!!!!!!!!!!!

jpphilips:

How many times have you gone to solve their own problems? they have one of the highest divorce rates in the world, have you intervened?
Their debt profile tantamount to the GDP of three European countries put together, have you rendered any assistance? they have the highest gun crimes in the world, have you intervened? always sitting cap in hand like a leper waiting on daddy USA for the next round of spoon feeding dvmb fvcks!

Errr......I live in US right now and pay taxes and volunteer.

So I am helping out in my own little way.

Don't assume anything about anyone until you have met them.

pDude:

Errr......I live in US right now and pay taxes and volunteer.

So I am helping out in my own little way.

Don't assume anything about anyone until you have met them.

I see , you are getting your asss whooped here for one of your too many moronic posts

Come back ,I never tire for you na

Khalessi: Praiseeeeeee the Lord! Please they should send it fast to west Africa.

Praise the what?

SMH

How are we sure its not another rumor?

pDude:

Exactly. When the thing was killing Africans, US didn't give a fvck. But when it affected 2 of their guys, they suddenly came out with a serum. Na wa o

https://www.nairaland.com/1849506/ebola-latest-us-rejects-nigerias#25335822

How come that suddenly you're an angel here?

Ajuonye oya reveal thyself

Truckpusher: https://www.nairaland.com/1849506/ebola-latest-us-rejects-nigerias#25335822

How come that suddenly you're an angel here?

Ajuonye oya reveal thyself

I have a multiple personality disorder