Modified

I thought it was HIV/AIDS or malaria.

@Charix. Heart disease is the number 1 Worldwide. In Developing countries like Nigeria. Malaria, HIV/AIDS, Diarrhea disease are most common and they are not worldwide leading causes of death. Thanks for your input.

Plasmodium falciparum, the etiologic agent of malaria and Human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), are co-endemic in many tropical and sub-tropical countries with the potential risk for enhanced clinical, hematological, and parasitological complications (Gregory et al., 2010). Malaria and HIV infections are the lead cause of morbidity and mortality in this region. Together they account for over 4 million deaths each year. Both infections affect those in poverty and contribute to poverty by hindering sustainable development (WHO, 2008).
Plasmodium falciparum malaria causes about 300-500 million clinical cases annually, of which 90% occur in sub-Saharan Africa. Approximately, more than one million deaths occur each year, primarily among children under five years of age (UNAIDS/ WHO, 2004). Aside from young children, pregnant women are also heavily affected, with resultant effects on maternal health, birth outcome and increased mother-to-child transmission (MTCT) of HIV in HIV positive mothers with placental malaria (UNAIDS/WHO, 2004). Sub-Saharan Africa is also a home to an estimated 25 million adults and children living with HIV/AIDS. Worldwide, 33 million people are living with HIV/AIDS (UNAID/WHO, 2004). In 2007, an estimated 2.1 million deaths were due to HIV infections, of which 1.6 million occurred in sub- Saharan Africa and over 1.9 million individuals mainly children were newly infected (WHO,2008). Given the overlap of their geographic distribution and resultant rates of co-infection, interactions between these two diseases pose major public health problems (WHO, 2008).
Early studies found little or no definitive interaction between malaria and HIV infections in either adult or children (Kublin et al., 2005). More recent research has shown that HIV infections predisposes to more frequent episodes of symptomatic, severe or complicated malaria including death in both children and adult (Grimwade et al., 2004) and it has also been associated with an increased rate of malaria treatment failure (Kamya et al., 2006). Malaria infection has been associated with an increase in plasma HIV viral load as well as a more rapid CD4+ T-cell decline (Mermin et al., 2006). Although, some of these interactions between malaria and HIV infections are known, these have not been extensively studied from an epidemiological perspective. Many aspects of the relationship between these interactions remain unanswered (Kalyesubula et al., 1997). Therefore examining the interactions between these all-too-common pathogens in the setting of immune cells would shed light on the effects on immune dysregulation, as different clinical manifestation of malaria has been associated with different states of immune dysregulation (Akanmori et al., 2000).

Go on.......
Click
http://uniprojectsearch.com/immunestatus-h…ia-hiv-malaria/

@Oraeri30. Thanks for your input. The topic says Number 1 killer disease in the world. Heart disease. And you are quoting out of context. Worldwide is not this region as stated in your post. " . Malaria and HIV infections are the lead cause of morbidity and mortality in this region. Together they account for over 4 million deaths each year."


You can readmore here.
http://www.who.int/mediacentre/factsheets/fs310/en/

Op thanks so much for bringing this much needed awareness, people need to know. Health is wealth

@Isotonic. You are welcome. Thanks for reading. Most of the diseases are preventable only if people are aware and do something about it. Which is our message. Hope you will continue to visit our blog and spread the message.

tvhealthblog:
@Isotonic. You are welcome. Thanks for reading. Most of the diseases are preventable only if people are aware and do something about it. Which is our message. Hope you will continue to visit our blog and spread the message.

Sure

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