Couple

Genotype Possible Combination Remark
Partner X Partner Y
AA AA AA AA AA AA Can Marry
AA AS AA AS AA AS Can Marry
AS AS AA AS AS SS Not to Marry
SS AA AS AS AS AS Can Marry
SS SS SS SS SS SS Not to Marry
AS SC SS AS AC SC Not to Marry
AS CC AC AC SC SC Not to Marry
AA SC AS AC AS AC Can Marry
AA CC AC AC AC AC Can Marry
Note: Three major groups of genotype are: AA (Normal); AS (Carrier), SS (Sickler). Others are SC AND CC.

Adaptation and Shifting Balance: An example from sickle-cell anemia
Sickle-cell refers to an allele at affects the beta-chain of hemoglobin
The allele, s, confers resistence to malaria
But, there is a pleiotropic effect of the allele when homozygous that causes severe anemia

Actually, there are three alleles at the beta locus:
A = ‘normal’, susceptible to malaria when homozygous
s = ‘sickle-cell’
c = recessive allele that gives high resistance when homozygous
The fitnesses of these genotypes is given below:

GENOTYPE RELATIVE FITNESS CONDITION
AA 0.9 susceptible
AS 1.0 (overdominance) resistant
SS 0.2 anemia
AC 0.9 susceptible
SC 0.7 anemia
CC 1.3 (note highest fitness) highly resistant
- See more at: http://sunsumfmonline.com/567/dr-brown-forum-on-genotype-information/#sthash.GYSp79Eh.dpuf

Nice thread

hu cares abt all dis nowadays.
Dem 4 dun qive d babe belle b4 dy remember maybe na SS OR DAT.
Op nice 1

Eye opener. Don't suffer de unborn ooo all in de name of love. Love ur child as u love ur partner

Olomubj:
Couple

Genotype Possible Combination Remark
Partner X Partner Y
AA AA AA AA AA AA Can Marry
AA AS AA AS AA AS Can Marry
AS AS AA AS AS SS Not to Marry
SS AA AS AS AS AS Can Marry
SS SS SS SS SS SS Not to Marry
AS SC SS AS AC SC Not to Marry
AS CC AC AC SC SC Not to Marry
AA SC AS AC AS AC Can Marry
AA CC AC AC AC AC Can Marry
Note: Three major groups of genotype are: AA (Normal); AS (Carrier), SS (Sickler). Others are SC AND CC.

Adaptation and Shifting Balance: An example from sickle-cell anemia
Sickle-cell refers to an allele at affects the beta-chain of hemoglobin
The allele, s, confers resistence to malaria
But, there is a pleiotropic effect of the allele when homozygous that causes severe anemia

Actually, there are three alleles at the beta locus:
A = ‘normal’, susceptible to malaria when homozygous
s = ‘sickle-cell’
c = recessive allele that gives high resistance when homozygous
The fitnesses of these genotypes is given below:

GENOTYPE RELATIVE FITNESS CONDITION
AA 0.9 susceptible
AS 1.0 (overdominance) resistant
SS 0.2 anemia
AC 0.9 susceptible
SC 0.7 anemia
CC 1.3 (note highest fitness) highly resistant
- See more at: http://sunsumfmonline.com/567/dr-brown-forum-on-genotype-information/#sthash.GYSp79Eh.dpuf

I don't get... Is the analysis saying dat AS and AC can marry? Pls enlighten me... #knowledge_is_power

SisiNini:


I don't get... Is the analysis saying dat AS and AC can marry? Pls enlighten me... #knowledge_is_power

yes of course the doctor that did the analysis is Uk doctor who base his professional on genotype though if you ask many doctors who are not in that professional 64% wil tel you they are match why the 36%wil tel you not in the sense that they are not in that profession.so the analysis was done by the UK doctor who base his profession on anything blood most especially genotype though am NT a doctor but with my research I got that information and it was proved and confirm

Olomubj:
Couple
Genotype Possible Combination Remark
Partner X Partner Y
AA AA AA AA AA AA Can Marry
AA AS AA AS AA AS Can Marry
AS AS AA AS AS SS Not to Marry
SS AA AS AS AS AS Can Marry
SS SS SS SS SS SS Not to Marry
AS SC SS AS AC SC Not to Marry
AS CC AC AC SC SC Not to Marry
AA SC AS AC AS AC Can Marry
AA CC AC AC AC AC Can Marry
Note: Three major groups of genotype are: AA (Normal); AS (Carrier), SS (Sickler). Others are SC AND CC.
Adaptation and Shifting Balance: An example from sickle-cell anemia
Sickle-cell refers to an allele at affects the beta-chain of hemoglobin
The allele, s, confers resistence to malaria
But, there is a pleiotropic effect of the allele when homozygous that causes severe anemia
Actually, there are three alleles at the beta locus:
A = ‘normal’, susceptible to malaria when homozygous
s = ‘sickle-cell’
c = recessive allele that gives high resistance when homozygous
The fitnesses of these genotypes is given below:
GENOTYPE RELATIVE FITNESS CONDITION
AA 0.9 susceptible
AS 1.0 (overdominance) resistant
SS 0.2 anemia
AC 0.9 susceptible
SC 0.7 anemia
CC 1.3 (note highest fitness) highly resistant
- See more at: http://sunsumfmonline.com/567/dr-brown-forum-on-genotype-information/#sthash.GYSp79Eh.dpuf

.




This is not clear enough, from the partner X and partner Y explanation, is it d case that SC and AC can marry as well as SS and AS, u don't want to mislead people with this, pls try and be as explicit as possible.

schendy:
.




This is not clear enough, from the partner X and partner Y explanation, is it d case that SC and AC can marry as well as SS and AS, u don't want to mislead people with this, pls try and be as explicit as possible.

please kindly take your time to go through the analysis very well please am not miss lead people and I can't miss lead people I did research base on my own personal issues of genotype and I came up with that through a UK base doctor who is a professional in the aspects if genotype so go through that analysis very well.because can marry is different from can not(can't) marry thank you

Yea. It would be callous for one to deliberately put their kids in such agonizing and hellish experience all in the name of love.

Olomubj:
yes of course the doctor that did the analysis is Uk doctor who base his professional on genotype though if you ask many doctors who are not in that professional 64% wil tel you they are match why the 36%wil tel you not in the sense that they are not in that profession.so the analysis was done by the UK doctor who base his profession on anything blood most especially genotype though am NT a doctor but with my research I got that information and it was proved and confirm

So because the doctor is UK based and specializes in genotype, AS can now marry SC?
If am correct they have the chances of birthing;
AS
SS
AC
SC
.
That's a 50% chance of having at a variant of Sickle cell disease. (either SS or SC) and this UK medical specialist endorsed this?
.
That's is ignorance

Abali1:

So because the doctor is UK based and specializes in genotype, AS can now marry SC?
If am correct they have the chances of birthing;
AS
SS
AC
SC
.
That's a 50% chance of having at a variant of Sickle cell disease. (either SS or SC) and this UK medical specialist endorsed this?
.
That's is ignorance

please kindly go through that analysis very well please

Olomubj:
please kindly go through that analysis very well please

If will please, help me analyze it again. Thank you.