Ever since the onset of human civilization,
new diseases have been surging up time and
again. Measles endemic in ancient China,
then the Smallpox outbreak in India in the
early 1500s, the plague in the middle ages…
entire societies have been crippled by
diseases. But these days, with all the
advances in health and technology, the
modern marvels in medicine has succeeded
in curbing some lethal diseases, to a point
that is. There still are diseases whose cure
remains elusive despite all the efforts from
medical communities. Here is a list of top 10
dangerous diseases that cannot be cured.

10. Asthma disease
Asthma disease

In this chronic disorder of lungs, the airways
get heavily inflamed and constricted. This
causes periodic breathlessness, coughs and
chest pains, the consequences ranging from
mild to life threatening. Asthmatic people
have incredibly sensitive airways which makes
them more susceptible to allergies. When the
conditions are worse than usual, patients
become more prone to asthmatic attacks or
episodes. More often then not, these attacks
can lead to absolute severity. The first of the
attacks can occur at any age, however about
half of the cases are found in children
younger than 10 years, with the number
inclined slightly more towards boys than that
of girls.
An estimated 300 million people worldwide
suffer from asthma, with 250,000 annual
deaths attributed to the disease. Even
though a well managed treatment can help
asthmatic people lead a normal life, a
precise cure to end it is yet to be discovered.

9. Polio Disease
polio disease

Not so long ago, there was not a place
spared from the terrible consequences of
polio epidemic. Even though most of the
world stands polio free as of right now, the
disease has been causing paralysis and
death to a substantial number of people
throughout human history. At the peak of its
epidemic around the 1940s and 1950s, over
half a million people either died or were
paralyzed by polio each year. Amid such
frenzied situations, the polio vaccine was
developed that made the vaccinated children
immune to the virus. And to this day, there
is no cure to polio. Once someone gets
infected by the polio virus, they cannot be
acutely cured. Polio can only be prevented by
using the polio vaccine, given multiple times
to children to protect them for life.
With the recent outbreak of Polio strain in
Syria with WPV1 strain, the most dangerous
type of polio virus that cripples the children
it infects, the rest of world, especially the
European countries are on alert to curb any
possible affects of the virus there. Until the
last strain of polio virus is eradicated or a
fail safe cure is found, the fight against polio
will keep on stretching to the coming years.

8. Ebola Disease
Ebola virus

It is caused by deadly Ebola virus named
after the Ebola river of Northern Congo where
it was first seen in 1976. There was a massive
outbreak that year in the then Zaire and
Sudan causing hundreds of deaths. The
outbreaks first started in the primates like
Gorilla, Chimpanzee and then in the
humans. A similar outbreak few years later
again in Zaire in 1995 also added to the
dead count. The virus is known to cause the
fatal Ebola Hemorrhagic Fever, also known as
Ebola Virus Disease (EVD). It results
in extreme fever, rash, and excessive
hemorrhaging in the body of diseased
person. According to WHO, of about 1850
known cases of Ebola so far, more than 1200
deaths have occurred, making Ebola a very
deadly pathogen.
So far there has not been any major Ebola
outbreak elsewhere in the world, which is
indeed fortunate since a cure to the disease
is yet to be found. The patients with Ebola
can only be given supportive treatment. But
an acute treatment to cure them does not
exist.

7. Diabetes Disease
diabetes disease

A few decades back, Diabetes was thought of
a rich man’s disease, the number of people
with diabetes constricted to the upper
echelon of society. But now, things could not
have been any more different. Diabetes has
emerged into a global epidemic with an
estimated 4 million deaths each year
accounted to it. Even more alarming is the
projection that total deaths caused by
diabetes is most likely to increase two folds
in the next 10 years. There are two types of
diabetes, Type 1 diabetes which is caused by
lack of insulin production and is extensively
seen in children and Type 2 diabetes
which results from the body’s ineffective use
of insulin. Type 2 diabetes adds up for 90%
of all diabetes cases and even though the
reports of this diabetes in children were
previously rare, the number have significantly
increased as of right now.
The biggest problem with diabetes is that is
can remain unseen for years, and by the time
it is diagnosed, more often then not the
disease would have reached life threatening
stage. It can lead to severe health
complications such as heart disease and
stroke, kidney disease, blindness, nerve
disease and amputations.

6. Creutzfeldt Jakob Disease
Creutzfeldt Jakob Disease

Creutzfeldt Jakob Disease (CJD) is an
incredibly rare and fatal brain disorder and
is more like Mad Cow Disease in humans. It
is so rare that only one person in a million
suffers from it around a year. But that does
not make this disorder any less dangerous.
The onset of the major symptoms occur after
60 years of age, and more than 90% of times,
the patients survive only a year after the first
symptoms. It all starts with failing memory,
behavioral changes, lack of coordination and
visual disturbances. But as the conditions
start to worsen, mental deterioration,
involuntary movements, hallucinations,
blindness and weakness of extremities
become more pronounced and this all may
lead to coma. This disease usually appears in
the later life and but its severity grows with
extreme rapidness.
CJD is thought to be caused by a
protien called a prion. A known cure to the
disease is still far from our grasp. Modern
medical techniques do help slow down the
disease but the final consequences can only
be prolonged.

5. Fatal Familial Insomnia
Disease

Fatal Familial Insomnia Disease
This disease is so rare that it has been
discovered only in 40 families worldwide. And
that might as well be about the only positive
aspect (and a fortunate one) about this
disease. It typically starts showing up
around the age of 50 years and death comes
usually after 7 to 36 months of the onset of
symptoms. Fatal Familial Insomnia (FFI) is
transmitted by genetic mutation, making it’s
transmission from parent to child a 50-50
chance. But everything else about it is wildly
unpredictable. The most baffling and
horrorful aspect of FFI is the complete
inability of the suffering person to sleep.
While the patients suffer from unbelievable
highs in pulse and blood pressure, excessive
sweating and an eventual loss of
coordination and other gross motor skills
(including speech), the thinking portions
remain intact, even as the rest of the body
deteriorates. The patients understand that
they will die, can talk and write freely till
their coordination lasts and understand
their fate up until their ultimate death.
At a time when neurologists around the
world are yet to grasp the complete
mechanism of this disease, any cure to this
disorder is still a big far cry.

4. Fibrodysplasia Ossificans
Progressiva Disease

Fibrodysplasia Ossificans Progressiva Disease
It is an extremely rare disease of the
connective tissue which causes the damaged
soft tissues to regrow as bones. This results
into complete ossification of damaged
tendons, ligaments and muscles; meaning all
the damaged connective tissues gets regrown
into bones, slowly imprisoning the sufferers
into their own skeletons. For this reason, this
abnormality is sometimes also referred as
Stone Man Syndrome. Children born with
Fibrodysplasia Ossificans Progressiva (FOP)
have deformed big toes, possibly missing a
joint or simply presenting with a notable
lump at the minor joint. The gene that
causes ossification is normally deactivated
once the fetus’ bones are completely formed
in the womb, but in patients with FOP, the
gene keeps on working.
As of right now, there is no known cure to
FOP. Even any attempt to surgically remove
the regrown bones results in more robust
bone growth, further worsening the
conditions.

3. Progeria Disease

Progeria Disease
It is a very rare genetic disorder in children
that leads to premature aging. Even though
a baby with this genetic mutation is born
normal and healthy, the symptoms start
emerging once the child reaches the age of
18-24 months. Children with progeria have
bodies similar to that of adults, with wrinkled
skin and poor eyesight, and an extremely low
number of patients survive for more than 13
years. The disease affects a single child in
every 8 million children and it takes its name
from two words, Pro meaning “before” or
“premature” and Geras meaning “Old age”.
Once progeria starts showing up, the child
develops signs of prominent eyes, scalp
veins, protruding ears, beaky nose, large
head with hair loss and other devastating
physical abnormalities.

So far, no treatments are known to have any
effect against progeria. All the potential
drugs developed so far are still in clinical
stage.

2. HIV/AIDS Disease

HIV AIDS disease
Due to it’s severity and rapid increase in the
number of infected population, HIV/AIDS has
been much talked about ever since it first
emerged in the early 1980s. Since its
inception, almost 70 million people have
been infected with the HIV virus and about
35 million people have died of AIDS. By the
end of 2011, a total of 34 million people were
living with HIV infection in the world, of
which 1.7 million people died that year. The
fact that it can be easily transmitted by
sexual contact, blood and even breast milk
makes it a very lethal disease, with the
number of affected people on the rise every
year. HIV infection deals a heavy
deterioration to the immune system, making
the body more susceptible to normal
infections and diseases. AIDS or the
Acquired Immune Deficiency Syndrome is the
most advanced stages of HIV infection,
characterized by the occurrence of more than
20 opportunistic infections and related
cancer.

Countries throughout the world run several
campaigns informing people on how to
prevent HIV infection. But as of now, AIDS
can only be prevented, a known cure that
totally eradicates the infecting virus from a
person is yet to be developed.

1. Cancer Disease

Cancer disease
The very fact that more people die of cancer
each year than from AIDS, malaria and
tuberculosis combined tells everything about
how dangerous it is. In 2008 alone, there
were 7.6 million deaths globally because of
cancer, accounting for 13% of the total
deaths that year. To worsen the matter, the
World Health Organization projects that
without immediate action, the global number
of deaths from cancer will increase by nearly
80% by 2030, with most occurring in low- and
middle-income countries. Cancer is a group
of diseases characterized by uncontrolled
growth and spread of abnormal cells. Overall,
there are more than 100 different types of
cancer. Five of the most lethal cancer that
kill men are lung, stomach, liver, colorectal
and oesophagus cancer. Similarly, breast,
lung, stomach, colorectal and cervical cancer
account for most deaths in women.
Of all the causes of cancer, use of tobacco is
easily the most preventable and it results in
22% of all cancer deaths. If diagnosed in
time, some of the cancer can be cured with
extensive therapies, but a fail-proof cure to
cancer still remains elusive.

Final Conclusion :

With every new era in the human history, we
have seen new developments, new
technologies and new lifestyles. But along
with them, we have also recorded the
emergence of new devastating infections and
dangerous diseases. Infectious diseases
emerging throughout history have included
some of the most feared plagues of the past.
New infections continue to emerge today,
while many of the old plagues are with us
still. These disease cause an unbelievably big
portion of all the deaths that occur in a year.
No matter how advanced the modern
technologies are and how capable the
medical society becomes, as long as there are
incurable diseases that keep on crippling
entire populations, the task remains to be
done.

Hmmm, may God help us

missKiffy:
Hmmm, may God help us

Amen

Don't worry guys: i'll discover the cure to cancer.

I wanted to reply but when i saw top ten i loyal.

lasstropinky:
Ever since the onset of human civilization,
new diseases have been surging up time and
again. Measles endemic in ancient China,
then the Smallpox outbreak in India in the
early 1500s, the plague in the middle ages…
entire societies have been crippled by
diseases. But these days, with all the
advances in health and technology, the
modern marvels in medicine has succeeded
in curbing some lethal diseases, to a point
that is. There still are diseases whose cure
remains elusive despite all the efforts from
medical communities. Here is a list of top 10
dangerous diseases that cannot be cured.

10. Asthma disease
Asthma disease

In this chronic disorder of lungs, the airways
get heavily inflamed and constricted. This
causes periodic breathlessness, coughs and
chest pains, the consequences ranging from
mild to life threatening. Asthmatic people
have incredibly sensitive airways which makes
them more susceptible to allergies. When the
conditions are worse than usual, patients
become more prone to asthmatic attacks or
episodes. More often then not, these attacks
can lead to absolute severity. The first of the
attacks can occur at any age, however about
half of the cases are found in children
younger than 10 years, with the number
inclined slightly more towards boys than that
of girls.
An estimated 300 million people worldwide
suffer from asthma, with 250,000 annual
deaths attributed to the disease. Even
though a well managed treatment can help
asthmatic people lead a normal life, a
precise cure to end it is yet to be discovered.

9. Polio Disease
polio disease

Not so long ago, there was not a place
spared from the terrible consequences of
polio epidemic. Even though most of the
world stands polio free as of right now, the
disease has been causing paralysis and
death to a substantial number of people
throughout human history. At the peak of its
epidemic around the 1940s and 1950s, over
half a million people either died or were
paralyzed by polio each year. Amid such
frenzied situations, the polio vaccine was
developed that made the vaccinated children
immune to the virus. And to this day, there
is no cure to polio. Once someone gets
infected by the polio virus, they cannot be
acutely cured. Polio can only be prevented by
using the polio vaccine, given multiple times
to children to protect them for life.
With the recent outbreak of Polio strain in
Syria with WPV1 strain, the most dangerous
type of polio virus that cripples the children
it infects, the rest of world, especially the
European countries are on alert to curb any
possible affects of the virus there. Until the
last strain of polio virus is eradicated or a
fail safe cure is found, the fight against polio
will keep on stretching to the coming years.

8. Ebola Disease
Ebola virus

It is caused by deadly Ebola virus named
after the Ebola river of Northern Congo where
it was first seen in 1976. There was a massive
outbreak that year in the then Zaire and
Sudan causing hundreds of deaths. The
outbreaks first started in the primates like
Gorilla, Chimpanzee and then in the
humans. A similar outbreak few years later
again in Zaire in 1995 also added to the
dead count. The virus is known to cause the
fatal Ebola Hemorrhagic Fever, also known as
Ebola Virus Disease (EVD). It results
in extreme fever, rash, and excessive
hemorrhaging in the body of diseased
person. According to WHO, of about 1850
known cases of Ebola so far, more than 1200
deaths have occurred, making Ebola a very
deadly pathogen.
So far there has not been any major Ebola
outbreak elsewhere in the world, which is
indeed fortunate since a cure to the disease
is yet to be found. The patients with Ebola
can only be given supportive treatment. But
an acute treatment to cure them does not
exist.

7. Diabetes Disease
diabetes disease

A few decades back, Diabetes was thought of
a rich man’s disease, the number of people
with diabetes constricted to the upper
echelon of society. But now, things could not
have been any more different. Diabetes has
emerged into a global epidemic with an
estimated 4 million deaths each year
accounted to it. Even more alarming is the
projection that total deaths caused by
diabetes is most likely to increase two folds
in the next 10 years. There are two types of
diabetes, Type 1 diabetes which is caused by
lack of insulin production and is extensively
seen in children and Type 2 diabetes
which results from the body’s ineffective use
of insulin. Type 2 diabetes adds up for 90%
of all diabetes cases and even though the
reports of this diabetes in children were
previously rare, the number have significantly
increased as of right now.
The biggest problem with diabetes is that is
can remain unseen for years, and by the time
it is diagnosed, more often then not the
disease would have reached life threatening
stage. It can lead to severe health
complications such as heart disease and
stroke, kidney disease, blindness, nerve
disease and amputations.

6. Creutzfeldt Jakob Disease
Creutzfeldt Jakob Disease

Creutzfeldt Jakob Disease (CJD) is an
incredibly rare and fatal brain disorder and
is more like Mad Cow Disease in humans. It
is so rare that only one person in a million
suffers from it around a year. But that does
not make this disorder any less dangerous.
The onset of the major symptoms occur after
60 years of age, and more than 90% of times,
the patients survive only a year after the first
symptoms. It all starts with failing memory,
behavioral changes, lack of coordination and
visual disturbances. But as the conditions
start to worsen, mental deterioration,
involuntary movements, hallucinations,
blindness and weakness of extremities
become more pronounced and this all may
lead to coma. This disease usually appears in
the later life and but its severity grows with
extreme rapidness.
CJD is thought to be caused by a
protien called a prion. A known cure to the
disease is still far from our grasp. Modern
medical techniques do help slow down the
disease but the final consequences can only
be prolonged.

5. Fatal Familial Insomnia
Disease

Fatal Familial Insomnia Disease
This disease is so rare that it has been
discovered only in 40 families worldwide. And
that might as well be about the only positive
aspect (and a fortunate one) about this
disease. It typically starts showing up
around the age of 50 years and death comes
usually after 7 to 36 months of the onset of
symptoms. Fatal Familial Insomnia (FFI) is
transmitted by genetic mutation, making it’s
transmission from parent to child a 50-50
chance. But everything else about it is wildly
unpredictable. The most baffling and
horrorful aspect of FFI is the complete
inability of the suffering person to sleep.
While the patients suffer from unbelievable
highs in pulse and blood pressure, excessive
sweating and an eventual loss of
coordination and other gross motor skills
(including speech), the thinking portions
remain intact, even as the rest of the body
deteriorates. The patients understand that
they will die, can talk and write freely till
their coordination lasts and understand
their fate up until their ultimate death.
At a time when neurologists around the
world are yet to grasp the complete
mechanism of this disease, any cure to this
disorder is still a big far cry.

4. Fibrodysplasia Ossificans
Progressiva Disease

Fibrodysplasia Ossificans Progressiva Disease
It is an extremely rare disease of the
connective tissue which causes the damaged
soft tissues to regrow as bones. This results
into complete ossification of damaged
tendons, ligaments and muscles; meaning all
the damaged connective tissues gets regrown
into bones, slowly imprisoning the sufferers
into their own skeletons. For this reason, this
abnormality is sometimes also referred as
Stone Man Syndrome. Children born with
Fibrodysplasia Ossificans Progressiva (FOP)
have deformed big toes, possibly missing a
joint or simply presenting with a notable
lump at the minor joint. The gene that
causes ossification is normally deactivated
once the fetus’ bones are completely formed
in the womb, but in patients with FOP, the
gene keeps on working.
As of right now, there is no known cure to
FOP. Even any attempt to surgically remove
the regrown bones results in more robust
bone growth, further worsening the
conditions.

3. Progeria Disease

Progeria Disease
It is a very rare genetic disorder in children
that leads to premature aging. Even though
a baby with this genetic mutation is born
normal and healthy, the symptoms start
emerging once the child reaches the age of
18-24 months. Children with progeria have
bodies similar to that of adults, with wrinkled
skin and poor eyesight, and an extremely low
number of patients survive for more than 13
years. The disease affects a single child in
every 8 million children and it takes its name
from two words, Pro meaning “before” or
“premature” and Geras meaning “Old age”.
Once progeria starts showing up, the child
develops signs of prominent eyes, scalp
veins, protruding ears, beaky nose, large
head with hair loss and other devastating
physical abnormalities.

So far, no treatments are known to have any
effect against progeria. All the potential
drugs developed so far are still in clinical
stage.

2. HIV/AIDS Disease

HIV AIDS disease
Due to it’s severity and rapid increase in the
number of infected population, HIV/AIDS has
been much talked about ever since it first
emerged in the early 1980s. Since its
inception, almost 70 million people have
been infected with the HIV virus and about
35 million people have died of AIDS. By the
end of 2011, a total of 34 million people were
living with HIV infection in the world, of
which 1.7 million people died that year. The
fact that it can be easily transmitted by
sexual contact, blood and even breast milk
makes it a very lethal disease, with the
number of affected people on the rise every
year. HIV infection deals a heavy
deterioration to the immune system, making
the body more susceptible to normal
infections and diseases. AIDS or the
Acquired Immune Deficiency Syndrome is the
most advanced stages of HIV infection,
characterized by the occurrence of more than
20 opportunistic infections and related
cancer.

Countries throughout the world run several
campaigns informing people on how to
prevent HIV infection. But as of now, AIDS
can only be prevented, a known cure that
totally eradicates the infecting virus from a
person is yet to be developed.

1. Cancer Disease

Cancer disease
The very fact that more people die of cancer
each year than from AIDS, malaria and
tuberculosis combined tells everything about
how dangerous it is. In 2008 alone, there
were 7.6 million deaths globally because of
cancer, accounting for 13% of the total
deaths that year. To worsen the matter, the
World Health Organization projects that
without immediate action, the global number
of deaths from cancer will increase by nearly
80% by 2030, with most occurring in low- and
middle-income countries. Cancer is a group
of diseases characterized by uncontrolled
growth and spread of abnormal cells. Overall,
there are more than 100 different types of
cancer. Five of the most lethal cancer that
kill men are lung, stomach, liver, colorectal
and oesophagus cancer. Similarly, breast,
lung, stomach, colorectal and cervical cancer
account for most deaths in women.
Of all the causes of cancer, use of tobacco is
easily the most preventable and it results in
22% of all cancer deaths. If diagnosed in
time, some of the cancer can be cured with
extensive therapies, but a fail-proof cure to
cancer still remains elusive.

Final Conclusion :

With every new era in the human history, we
have seen new developments, new
technologies and new lifestyles. But along
with them, we have also recorded the
emergence of new devastating infections and
dangerous diseases. Infectious diseases
emerging throughout history have included
some of the most feared plagues of the past.
New infections continue to emerge today,
while many of the old plagues are with us
still. These disease cause an unbelievably big
portion of all the deaths that occur in a year.
No matter how advanced the modern
technologies are and how capable the
medical society becomes, as long as there are
incurable diseases that keep on crippling
entire populations, the task remains to be
done.

no 10 and 7 can be controlled...

God no ho allow us get em