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Sickle Cell Anaemia - Genetic Causes Of Sickle Cell Diseases by airowblog: 6:48pm On Feb 02, 2016 |
Below are Genetic causes of Sickle cell disease
•MUTATION: sickle cell gene mutation probably
arose spontaneously in different geographic
areas, as suggested by restriction endonuclease
analysis. These variants are known as
Cameroon,
Senegal, Benin Republic, Bantu and Saudi-
Asian.
Their clinical importance springs from the fact
that some of them are associated with higher
HBF
level, e.g; Senegal and Saudi-Asian variants,
and
tend to have milder disease.
•HETEROZYGOUS: in people heterozygous for
Hgbs (carriers of sickling Haemoglobin), the
polymerization problems are minor, be because
the normal allele is able to produce over 50% of
the haemoglobin.
HOMOZYGOUS: in people homozygous for Hgbs,
the presence of long chain polymers of Hbs
distort the shape of the red blood cell from a
smooth doughnut-like shape to ragged and full
of
spikes, making it fragile and susceptible
to......continue >>>
www.rowlandokonko.com/2016/02/Biology-
Sickle-cell-anamia-genetics-diseases.html?m=0 |
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