Whatever the disease may be, it's simply  when you read about this man's story.
http://www.gidilinks.com/2011/10/las-vegas-man-with-100-pound-scrotum.html

I've read about this also and it's really sad to know cases like this. Wesley Warren Jr. of Las Vegas, Nev., doesn't want a 100-pound scrotum, but that's what he has and now, this man with 100-pound scrotum seeks money for surgery. The 47-year-old previous security officer is currently on disability, because having a 100-pound scrotum makes regular living impossible for him. Now his scrotum is filled with liquid and as large as watermelons. Medical doctors blame lymphatic filariasis and according to medical experts familiar with the case, the scrotum could even continue to grow.